Research theme for competitive and other funds (6)：
2021 - 2023 シングルセルレベルでのヒトT細胞白血病ウイルス感染細胞の分化転換の検証
2019 - 2022 Elucidation of the pathogenesis of adult T-cell leukemia using chromatin structural data at various levels of hematopoietic differentiation
2019 - 2021 クロマチン構造解析から明らかにする成人T細胞白血病の発症分子機構
2015 - 2019 細胞分化の可塑性を制御する核内構造ダイナミクスの解明 研究課題
2015 - 2018 腫瘍内エピゲノム不均一性を解明する1細胞クロマチン構造解析技術の開発
2014 - 2016 一細胞レベルの転写制御解析による細胞分化の理解
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Papers (15)：
Kosuke Toyoda, Jun-Ichirou Yasunaga, Takafumi Shichijo, Yuichiro Arima, Kenichi Tsujita, Azusa Tanaka, Tarig Salah, Wenyi Zhang, Osama Hussein, Miyu Sonoda, et al. HTLV-1 bZIP factor-induced reprogramming of lactate metabolism and epigenetic status promote leukemic cell expansion. Blood cancer discovery. 2023
豊田 康祐, 安永 純一朗, 田中 梓, 栗田 大輔, 渡辺 美穂, 七條 敬文, 三好 寛明, 大島 孝一, 松岡 雅雄. HTLV-1 bZIP factorが誘導するTAp73は,MCT1・MCT4双方の発現を介してがん代謝の乳酸排泄を促進する(HTLV-1 bZIP factor-driven TAp73 promotes lactate excretion from ATL cells via induction of MCT1 and MCT4). 日本癌学会総会記事. 2022. 81回. E-1016
Akihiro Fujimoto, Jing Hao Wong, Yukiko Yoshii, Shintaro Akiyama, Azusa Tanaka, Hitomi Yagi, Daichi Shigemizu, Hidewaki Nakagawa, Masashi Mizokami, Mihoko Shimada. Whole-genome sequencing with long reads reveals complex structure and origin of structural variation in human genetic variations and somatic mutations in cancer. Genome Medicine. 2021. 13. 1. 65-65
Azusa Tanaka, Yasuhiro Ishitsuka, Hiroki Ohta, Akihiro Fujimoto, Jun-ichirou Yasunaga, Masao Matsuoka. Systematic clustering algorithm for chromatin accessibility data and its application to hematopoietic cells. PLOS Computational Biology. 2020. 16. 11. e1008422-e1008422
Jing Hao Wong, Daichi Shigemizu, Yukiko Yoshii, Shintaro Akiyama, Azusa Tanaka, Hidewaki Nakagawa, Shu Narumiya, Akihiro Fujimoto. Identification of intermediate-sized deletions and inference of their impact on gene expression in a human population. Genome Medicine. 2019. 11. 1. 44-44
Human T-cell leukemia virus alters the epigenetic landscape and core regulatory circuitry in infected cells
(Keystone Symposia Conference: Single Cell Omics, Stockholm, Sweden 2017)
Analysis of the chromatin status in an ultra-low scale
(Chromatin and Epigenetics: From Omics to Single Cells, Strasbourg, France 2014)
Molecular mechanisms of apoptosis suppression by HTLV-1 bZIP factor in HTLV-1 infected cells
(16th International conference on human retrovirology: HTLV and Related viruses, Montreal, Canada 2013)
Education (3)：
2008 - 2014 京都大学医学研究科
2006 - 2008 Kyoto University Graduate School of Science Division of Chemistry
2002 - 2006 Kyoto University Faculty of Science
Professional career (1)：
医科学博士 (京都大学)
Work history (4)：
2019/07 - 現在 東京大学大学院医学系研究科 日本学術振興会特別研究員 (RPD)
2019/01 - 2019/06 Kyoto University Graduate School of Medicine
2015/04 - 2018/12 Kyoto University Graduate School of Medicine
