Research field (11)：
Nutrition and health science
, Tumor biology
, Experimental pathology
, Anatomy
, Clinical pharmacy
, Morphology, anatomy
, Veterinary medicine
, Laboratory animal science
, Hygiene and public health (laboratory)
, Internal medicine - General
, Gastroenterology
Research theme for competitive and other funds (37)：
2024 - 2028 Novel therapeutic strategies to overcome intestinal fibrosis in Crohn's disease
2024 - 2027 Establishment of Mass Production Method and Functional Enhancement of Mesenchymal Stem Cells for Liver Regeneration Therapy
2017 - 2020 The development of liver regeneration therapy with higher therapeutic effects on liver cirrhosis using a middle-large size liver cirrhosis model.
2017 - 2020 Development of cell-free liver regeneration therapy with the anticipatory method to culture higher-quality MSCs for liver cirrhosis
2016 - 2020 Age and sex differences in satellite cell activation during step up and down exercise
2016 - 2019 Effects of a novel oral iron chelator on refractory digestive system cancers
2016 - 2018 Development of anti-fibrotic therapies for liver fibrosis by the regulation of Rho family GTPases of macrophages.
2015 - 2018 The analysis and identification of bome marrow drived liver repair cell
2014 - 2017 Basic research to develop next generation cell therapy for improvement of liver fibrosis.
2014 - 2017 Research and development for liver regeneration therapy with higher-therapeutic effects using the higher-functioning cultured bone marrow mesenchymal stem cells
2013 - 2017 Utility of herbal medicine for remission maintenance therapy of ulcerative colitis
2013 - 2016 Establishment of the bone marrow stromal cell autotransplantation therapy for the chronic liver in dogs
2013 - 2016 Development of Medaka Model for Analysis of Angiogenesis and Kupffer cell
2012 - 2015 The analysis of small bone marrow drived liver repair cell
2012 - 2014 Development of the analytical method of the cancer stem cell using the ATP sensor in the cell
2011 - 2013 The development of new combination therapy with deferasirox and sorafenib on advanced hepatocellular carcinama
2011 - 2012 Basic research for chronotherapy focused on liver regeneration andliver steatosis by circadian clock
2010 - 2012 The basic research of the development of future generation cell therapy used bone marrow derived liver repaid cell
2010 - 2012 Both Herbal medicine Bofu-tsusho-san (TJ-62) and Dai-saiko-to (TJ-8) prevent liver fibrosis and hepatocarcinogenesis in rat liver cirrhosis.
2010 - 2011 Development of new gene transfer system for small fish
2009 - 2010 非アルコール性脂肪性肝炎関連発癌に対する戦略的研究
2009 - 2010 THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE AND REPAIR FUNCTION OF BONE MARROW CELL IN CIRRHOSIS MICE AND NASH MICE
2008 - 2010 Development of a novel therapy using the iron chelator for advanced hepatocellular carcinoma
2008 - 2009 血管観察トランスジェニックメダカを用いた非アルコール性脂肪性肝炎の病態解析
2007 - 2009 Mechanism of fibrolysis and effect on cancer by autologus bone marrow cell infusion therapy for liver cirrhosis
2007 - 2008 The effect of Herbal medicine Bofu-tsusho-san(TJ-62)and the Crude Drugs with hepatic steatosis
2007 - 2008 THE ELECTRON MICROSCOPICAL ANALYSIS FOR CELL LINEAGE OF BONE MARROW STEM CELL DIFFERENTIATION IN CIRRHOSIS MICE
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Papers (90)：
Yukari Inoue, Akiyo Ishiguro, Yutaka Suehiro, Yuki Kunimune, Yuko Yamaoka, Shinichi Hashimoto, Katsuhiko Nakamura, Atsushi Goto, Koichi Hamabe, Toshihiko Matsumoto, et al. A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma. Cancer science. 2024
Koichi Fujisawa, Toshihiko Matsumoto, Naoki Yamamoto, Takahiro Yamasaki, Taro Takami. Metabolic Analysis of DFO-Resistant Huh7 Cells and Identification of Targets for Combination Therapy. Metabolites. 2023. 13. 10
Riki Okita, Nobutaka Kawamoto, Masanori Okada, Hidetoshi Inokawa, Naoki Yamamoto, Tomoyuki Murakami, Eiji Ikeda. Preoperative neutrophil-to-lymphocyte ratio correlates with PD-L1 expression in immune cells of patients with malignant pleural mesothelioma and predicts prognosis. Scientific reports. 2023. 13. 1. 5263-5263
Takuma Hayashi, Naoki Yamamoto, Gene Kurosawa, Kaori Tajima, Mariko Kondo, Noriko Hiramatsu, Yu Kato, Miho Tanaka, Hisateru Yamaguchi, Yoshikazu Kurosawa, et al. A Novel High-Throughput Screening Method for a Human Multicentric Osteosarcoma-Specific Antibody and Biomarker Using a Phage Display-Derived Monoclonal Antibody. Cancers. 2022. 14. 23
Riki Okita, Yuka Mimura-Kimura, Nobutaka Kawamoto, Naoki Yamamoto, Masashi Umeda, Masanori Okada, Hidetoshi Inokawa, Yusuke Mimura, Tomoyuki Murakami, Masao Nakata, et al. Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma who underwent extra-pleural pneumonectomy. Cancer immunology, immunotherapy : CII. 2022
