Ogawa Haruo

オガワハルオ | Ogawa Haruo

Affiliation and department：
Homepage URL (1)： https://www.pharm.kyoto-u.ac.jp/structbl/

Research field (1)： Structural biochemistry

Research keywords (4)： membrane receptor , ion channel , ion pump , Structural biology

Research theme for competitive and other funds (20)：

2023 - 2028 Molecular basis and physiological significance of O-mannosyl glycans in mammals
2022 - 2025 Elucidation of molecular mechanism for depolarization-induced Ca2+ release using novel reconstitution system
2022 - 2025 Development of RyR2-specific inhibitors and activators and their application as antiarrhythmic agents
2021 - 2024 Structural analysis of the gating mechanism of cardiac ryanodine receptor
2021 - 2024 GCase受容体の構造生物学ーリガンドの認識機構と結合シグナルの分子内伝達機構

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Papers (48)：

Haruo Ogawa, Masami Kodama. Structural insight into hormone recognition by the natriuretic peptide receptor-A. The FEBS Journal. 2024
Sorachi Miwa, Hiroshi Takikawa, Rina Takeuchi, Ryo Mizunuma, Keita Matsuoka, Haruo Ogawa, Hiroaki Kato, Kiyosei Takasu. Structure-ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1. ACS Medicinal Chemistry Letters. 2024
Yoshiki Inoue, Tomohiro Yamaguchi, Tetsuo Otsuka, Yuto Utsunomiya, Dongqing Pan, Haruo Ogawa, Hiroaki Kato. Structure-based alteration of tryptophan residues of the multidrug transporter CmABCB1 to assess substrate binding using fluorescence spectroscopy. Protein Science. 2022. 31. 6
Takuya Kobayashi, Akihisa Tsutsumi, Nagomi Kurebayashi, Kei Saito, Masami Kodama, Takashi Sakurai, Masahide Kikkawa, Takashi Murayama, Haruo Ogawa. Molecular basis for gating of cardiac ryanodine receptor explains the mechanisms for gain- and loss-of function mutations. Nature Communications. 2022. 13. 1. 2821
Hideki Itoh, Takashi Murayama, Nagomi Kurebayashi, Seiko Ohno, Takuya Kobayashi, Yusuke Fujii, Masaya Watanabe, Haruo Ogawa, Toshihisa Anzai, Minoru Horie. Sudden death after inappropriate shocks of implantable cardioverter defibrillator in a catecholaminergic polymorphic ventricular tachycardia case with a novel RyR2 mutation. Journal of electrocardiology. 2021. 69. 111-118

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MISC (17)：

水沼諒, 小田島圭, 三和空知, 瀧川紘, 高須清誠, 小川治夫, 加藤博章, 加藤博章. Multidrug-recognition mechanism of ABC transporter by X-ray crystallography. 日本薬学会年会要旨集(Web). 2023. 143rd
Hirofumi Shimizu, Takuya Kobayashi, Masayuki Iwamoto, Kentaro Kajiwara, Nagomi Kurebayashi, Haruo Ogawa, Takashi Murayama. Single-Molecule Twisting Motions During Gating of the Human TRPV1 Channel Recorded with Sub-Millisecond Time Resolution. BIOPHYSICAL JOURNAL. 2020. 118. 3. 22A-22A
Toshiko Yamazawa, Haruo Ogawa, Takashi Murayama, Maki Yamaguchi, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kanemaru Kazunori, Takashi Sakurai, Masamitsu Iino. Molecular Dynamics and Ca2+ Imaging of Mutant Type 1 Ryanodine Receptor. BIOPHYSICAL JOURNAL. 2020. 118. 3. 98A-98A
Toshiko Yamazawa, Haruo Ogawa, Maki Yamaguchi, Takashi Murayama, Hideto Oyamada, Junji Suzuki, Nagomi Kurebayashi, Kazunori Kanemaru, Takashi Sakurai, Iino Masamitsu. Investigation of Mutant Ryanodine Receptor Channel Activity using Functional Analysis and Molecular Dynamics. BIOPHYSICAL JOURNAL. 2019. 116. 3. 521A-522A
村山尚, 呉林なごみ, 湯浅磨里, 石上, 森修一, 鈴木志奈, 秋間龍之介, 小川治夫, 鈴木純二, 金丸和典, et al. 小胞体内Ca2+濃度測定を利用した新規RyR1阻害薬のハイスループットスクリーニング. 日本筋学会学術集会プログラム・抄録集. 2018. 4回. 180-180

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Work history (10)：

2021/04 - 現在 Kyoto University Graduate School of Pharmaceutical Sciences Associate Professor
2018/04 - 2021/03 The University of Tokyo Institute for Quantitative Biosciences, Laboratory of Protein Expression and Production Associate Professor
2010/07 - 2018/03 The University of Tokyo Institute of Molecular and Cellular Biosciences Associate Professor
2009/04 - 2010/06 The University of Tokyo Institute of Molecular and Cellular Biosciences Associate Professor
2007/06 - 2009/03 The University of Tokyo Institute of Molecular and Cellular Biosciences

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