Research keywords (8)：
顎骨骨髄炎
, Diffuse Sclerosing Osteomyelitis(DSO)
, 薬剤関連顎骨壊死
, Medication-Related Osteonecrosis of the Jaws(MRONJ)
, 口腔
, HLA/KIR
, 微生物叢
, Actinomyces
Research theme for competitive and other funds (5)：
2021 - 2024 薬剤関連顎骨壊死に関わる微生物の疾患関連遺伝子と新たなサブタイプの解析
2020 - 2022 顎骨骨髄炎の新たな疾患概念の確立とバイオマーカーに関する研究
2019 - 2020 アミノ酸トランスポーターSLC15A3による新規がん進展機構の解明
2016 - 2019 骨髄炎感受性の新規遺伝的・免疫学的要因としてのHLA/KIR相互作用の解析
2015 - 2016 骨髄炎感受性の新規遺伝的リスク要因としてのHLA/KIR多様性の解析
Papers (7)：
Hiroko Yahara, Souichi Yanamoto, Miho Takahashi, Yuji Hamada, Takuya Asaka, Yoshimasa Kitagawa, Kuniyasu Moridera, Kazuma Noguchi, Yutaka Maruoka, Koji Yahara. Shotgun metagenomic analysis of saliva microbiome suggests Mogibacterium as a factor associated with chronic bacterial osteomyelitis. PloS one. 2024. 19. 5. e0302569
Sadao Aoki, Hiroko Yahara, Ryoma Nakao, Osamu Tsuzukibashi, Koji Yahara. Development of selective isolation media for detecting the genera Actinomyces and Schaalia from oral specimens containing indigenous bacteria. Access microbiology. 2024. 6. 5
Hiroko Yahara, Souichi Yanamoto, Miho Takahashi, Yuji Hamada, Haruo Sakamoto, Takuya Asaka, Yoshimasa Kitagawa, Kuniyasu Moridera, Kazuma Noguchi, Masaya Sugiyama, et al. Whole blood transcriptome profiling identifies gene expression subnetworks and a key gene characteristic of the rare type of osteomyelitis. Biochemistry and biophysics reports. 2022. 32. 101328-101328
Hiroko Yahara, Akimitsu Hiraki, Yutaka Maruoka, Aki Hirabayashi, Masato Suzuki, Koji Yahara. Shotgun metagenome sequencing identification of a set of genes encoded by Actinomyces associated with medication-related osteonecrosis of the jaw. PloS one. 2020. 15. 11. e0241676
