KOHYAMA Kuniko

Research field (1)： Neurology

Research keywords (9)： autoimmune disease , autoantibody , anti-MOG antibody , anti-NMDAR antibody , EAE, experimental autoimmune encephalomyelitis , EAC, experimental autoimmune myocarditis , Alzheimer's disease , amyloid β vaccine, Aβ vaccine , DNA vaccine

Research theme for competitive and other funds (12)：

2012 - 2015 Generation of new DNA vaccine plasmid for the therapy of Alzheimer's disease
2009 - 2011 Development of a new and effective DNA vaccine for Alzheimer's disease
2007 - 2008 Analysis of Abeta reduction mechanisms by non-viral DNA vaccine therapy for Alzheimer's disesase
2006 - 2007 ラット拡張型心筋症モデルにおける蛋白分解酵素MMPの作用機序解析及び治療法の開発
2005 - 2006 Development of non-viral A beta DNA vaccines against Alzheimer's disease

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Papers (39)：

Kengo Moriyama, Asako Horino, Kuniko Kohyama, Yasumasa Nishito, Tomohiro Morio, Hiroshi Sakuma. Oxygen-Glucose Deprivation Increases NR4A1 Expression and Promotes Its Extranuclear Translocation in Mouse Astrocytes. Brain sciences. 2024. 14. 3
Kuniko Kohyama, Hiroya Nishida, Kimihiko Kaneko, Tatsuro Misu, Ichiro Nakashima, Hiroshi Sakuma. Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein. Frontiers in neuroscience. 2023. 17. 1014071-1014071
Hiroya Nishida, Kuniko Kohyama, Satoko Kumada, Jun-Ichi Takanashi, Akihisa Okumura, Asako Horino, Kengo Moriyama, Hiroshi Sakuma. Evaluation of the Diagnostic Criteria for Anti-NMDA Receptor Encephalitis in Japanese Children. Neurology. 2021. 96. 16. e2070-e2077
Tomonori Suzuki, Kuniko Kohyama, Kengo Moriyama, Mariko Ozaki, Setsuko Hasegawa, Taro Ueno, Minoru Saitoe, Tomohiro Morio, Masaharu Hayashi, Hiroshi Sakuma. Extracellular ADP augments microglial inflammasome and NF-κB activation via the P2Y12 receptor. European journal of immunology. 2020. 50. 2. 205-219
Taiki Shima, Hiroshi Sakuma, Tomonori Suzuki, Kuniko Kohyama, Takako Matsuoka, Masaharu Hayashi, Akihisa Okumura, Toshiaki Shimizu. Effects of antiepileptic drugs on microglial properties. Epilepsy and Seizure. 2018. 10. 1. 22-32

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MISC (6)：

新見直子, 神山邦子, 松本陽. 神経免疫実験モデル実験的自己免疫性脳脊髄炎でのMMPの役割とミノサイクリン投与の影響. 日本神経免疫学会学術集会抄録集. 2012. 24回. 87-87
神山邦子, 新見直子, 松本陽. EAEのエフェクターT細胞は病型によって異なる可能性がある. 日本神経免疫学会学術集会抄録集. 2012. 24回. 125-125
新見直子, 神山邦子, 松本陽. EAE-2 siRNAによる自己免疫性脳脊髄炎の治療. 日本神経免疫学会学術集会抄録集. 2011. 23回. 68-68
竹宮孝子, 竹内千仙, 松本陽, 神山邦子, 植松智, 審良静男, 山形要人, 文沢久美子. 多発性硬化症における膜型プロスタグランジンE合成酵素(mPGES-1)の修飾作用(Moduratory effect of Microsomal prostaglandin E synthase-1 on multiple sclerosis). 神経化学. 2010. 49. 2-3. 586-586
Takako Takemiya, Chisen Takeuchi, Yoh Matsumoto, Kuniko Kohyama, Satoshi Uematsu, Shizuo Akira, Kanato Yamagata, Kumiko Fumisawa. Moduratory effect of Microsomal prostaglandin E synthase-1 on multiple sclerosis. NEUROSCIENCE RESEARCH. 2010. 68. E198-E199

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Education (3)：

1995 - 1997 Hokkaido University Graduate School of Science and Faculty of Science Department of Biology
1993 - 1995 Hirosaki University Graduate School of Science and Faculty of Science Department of Biology
1989 - 1993 Hirosaki University Faculty of Science Department of Biology

Work history (2)：

2011/04 - 現在 Tokyo Metropolitan Institute of Medical Science
1997/04 - 2011/03 Tokyo Metropolitan Institute for Neuroscience

Awards (1)：

2016/09 - 第28回日本神経免疫学会学術集会ベストポスター賞自己免疫性脱髄疾患における抗MOG抗体の細胞傷害性に関する解析

Association Membership(s) (3)：

日本神経病理学会 , 日本小児神経学会 , 日本神経免疫学会

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