Research field (3):
Pathobiochemistry
, Hematology and oncology
, Internal medicine - General
Research theme for competitive and other funds (12):
2019 - 2022 Construction of new clinical laboratory test by magnetic homogenous assay
2015 - 2020 Development of advanced biosensing systems utilizing magnetic markers and magnetic sensors
2015 - 2018 Development of micro blood clinical examination with deepening of homogeneous assay by magnetic detection
2014 - 2018 Investigation into thrombophilia indigenous to Asian populations and establishment of new strategy for preventing thrombosis
2013 - 2016 Studies on thrombophilia -deficiency and mutation of protein S-
2012 - 2016 Development of biological immmunoassay system using magnetic markers
2012 - 2015 Development of homogenous and quantitative immunoassay system with magnetic detection
2009 - 2011 Liquid-phase detection of biological targets with magnetic markers
2009 - 2011 Structural Study on Human Red Cell Band 3 Protein, AE1.
2008 - 2010 Quantitative immunoassay using magnetic detection for rapid and high sensitive clinical biochemistry
2007 - 2008 磁気検出法による高速・高感度な微量物質の定量的分析手法の開発
2006 - 2008 Magnetic Immunoassay system without BF separation for rapid and sensitive detection of biological targets
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Papers (46):
Natsuko Yokota, Reiko Inoue, Keiko Kawamura, Katsuko Egashira, Hiroyuki Kuma, Kiyoko Kato. The effects of dienogest and combined oral contraceptives on protein S-specific activity in endometriosis patients. European journal of obstetrics, gynecology, and reproductive biology. 2024. 295. 67-74
Ryo Matsuda, Ruri Someya, Mutsumi Kobayashi, Eri Nakao, Momoka Hamasaki, Misuzu Shigeta, Hinako Hatae, Hiroyuki Kuma. A quantitative assay system for protein C activity, the regulator of blood coagulation, based on a chromogenic method mimicking the blood coagulation cascade. Practical laboratory medicine. 2023. 37. e00345
Yoshihiro Sato, Toshitaka Sugi, Rie Sakai, Hiroyuki Kuma. The role of epidermal growth factor-like domain-related abnormalities, protein S Tokushima, and anti-protein S autoantibodies in pregnancy loss. Journal of reproductive immunology. 2022. 150. 103476-103476
Xiuri Jin, Sachiko Kinoshita, Hiroyuki Kuma, Tomohide Tsuda, Tatsusada Yoshida, Dongchon Kang, Naotaka Hamasaki. Reduced Activity of Protein S in Plasma: A Risk Factor for Venous Thromboembolism in the Japanese Population. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS. 2021. 27
Hiroyuki Kuma, Ryo Matsuda, Asuna Nakashima, Kazuna Motoyama, Shinya Takazaki, Hinako Hatae, Xiuri Jin, Tomohide Tsuda, Hiroko Tsuda, Naotaka Hamasaki. Protein S-specific activity assay system is not affected by direct oral anticoagulants. Thrombosis Research. 2018. 168. 60-62
染矢留里, 松田諒, 小林睦美, 中尾英里, 波多江日成子, 隈博幸. Development of quantitative assay for protein C, blood coagulation regulation factor. 日本薬学会年会要旨集(Web). 2023. 143rd
胸元彩, 土屋玲子, 阿部靖之, 波多江日成子, 隈博幸. Risk analysis of postoperative venous thromboembolism by measurement of protein S specific activity. 日本薬学会年会要旨集(Web). 2023. 143rd
須田有希乃, 豊あい, 松田諒, 波多江日成子, 隈博幸. Anticoagulant potential of dabigatran in blood using peptide substrates. 日本薬学会年会要旨集(Web). 2023. 143rd
工藤匡朗, 高島啓吾, 矢野里桜, 波多江日成子, 隈博幸. Crystallization and structure analysis of anion exchange domains using LCP method in human erythrocyte membrane protein Band 3. 日本薬学会年会要旨集(Web). 2023. 143rd
白木理奈, 坂田志織, 波多江日成子, 隈博幸. Examination of expression condition of normal and mutant protein C molecules. 日本薬学会年会要旨集(Web). 2023. 143rd