Rchr
J-GLOBAL ID:201801003384682070   Update date: Apr. 12, 2024

Kurosawa Toshiki

Kurosawa Toshiki
Affiliation and department:
Homepage URL  (1): https://www.bbb-teikyo.com/
Research field  (1): Clinical pharmacy
Research keywords  (5): 有機カチオントランスポーター ,  薬物動態学 ,  ヒトiPS細胞 ,  Transporter ,  Blood-Brain barieer
Research theme for competitive and other funds  (3):
  • 2022 - 2025 Creation and clinical application of 3D brain barrier chips using human iPS cells
  • 2021 - 2024 ヒト脳微小環境を再現するヒトiPS細胞由来血液脳関門マイクロチップの構築と評価
  • 2019 - 2022 Functional elucidation of human blood-brain barrier using iPS-derived brain microvascular entdothelial cells
Papers (13):
  • Tomoko Yamaguchi, Daiki Sako, Toshiki Kurosawa, Misae Nishijima, Ayaka Miyano, Yoshiyuki Kubo, Sumio Ohtsuki, Kenji Kawabata, Yoshiharu Deguchi. Development and Functional Evaluation of MDR1-Expressing Microvascular Endothelial-Like Cells Derived from Human iPS Cells as an In Vitro Blood-Brain Barrier Model. Journal of pharmaceutical sciences. 2023
  • Kurosawa T, Yuma Tega, Yasuo Uchida, Higuchi K, Tabata H, Sumiyoshi T, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. Pharmaceutics. 2022. 14. 8. 1683-1683
  • Kurosawa T, Sako D, Tega Y, Debori Y, Tomihara Y, Aoyama K, Kubo Y, Amano N, Yoshiharu Deguchi. Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical research. 2022
  • Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi. Construction and Functional Evaluation of a Three-Dimensional Blood-Brain Barrier Model Equipped With Human Induced Pluripotent Stem Cell-Derived Brain Microvascular Endothelial Cells. Pharmaceutical Research. 2022
  • Atsushi Kitamura, Kei Higuchi, Toshiki Kurosawa, Takashi Okura, Yoshiyuki Kubo, Yoshiharu Deguchi. Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model. Biological & pharmaceutical bulletin. 2022. 45. 10. 1585-1589
more...
MISC (28):
  • Toshiki Kurosawa, Daiki Sako, Yoshiyuki Kubo, Yoshiharu Deguchi. Construction of human iPS cells-derived blood-brain barrier model and evaluation of transporter function. Drug Delivery System. 2023. 38. 2. 117-124
  • 黒澤俊樹. 若手が取り組む動態研究「トランスポーターの機能から見るヒトiPS細胞由来血液脳関門モデルの有用性」. 日本薬物動態学会 ニュースレター. 2022. 37. 4. 9-14
  • 佐孝 大樹, 黒澤 俊樹, 山口 朋子, 久保 義行, 川端 健二, 出口 芳春. P-gp発現ヒトiPS細胞由来脳毛細血管内皮細胞における輸送体機能評価. 日本薬学会年会要旨集. 2022. 142年会. 28C-pm05S
  • 黒澤俊樹, 手賀悠真, 佐孝大樹, 出堀泰之, 冨原裕美, 天野信之, 出口芳春. Construction of 3D BBB model using brain microvascular endothelial cells derived from human induced pluripotent stem cells. 日本薬剤学会年会講演要旨集(CD-ROM). 2021. 36th
  • 古西修希, 伊藤慎悟, 上村立記, 増田豪, 樋口慧, 黒澤俊樹, 手賀悠真, 出口芳春, 大槻純男. Effects of Loss of P-glycoprotein of blood-brain barrier homeostasis. 日本薬剤学会年会講演要旨集(CD-ROM). 2020. 35年会. 177-177
more...
Lectures and oral presentations  (33):
  • ヒト不死化脈絡叢上皮細胞株HIBCPP細胞における輸送体発現および物質輸送能の評価
    (日本薬学会第144年会 2024)
  • ヒトiPS細胞由来血液脳関門モデルを用いたD-angiopep-2輸送機構の評価
    (日本薬学会第144年会 2024)
  • ヒトiPS細胞由来血液脳関門モデルを用いた輸送解析およびMPS構築への応用
    (CBI学会2023年大会、フォーカストセッション FS06「先端的計測技術」 2023)
  • Construction and functional evaluation of a fluidic 3D blood-brain barrier system using human iPS cells-derived BMEC-like cells
    (Cerebral Vascular Biology Meeting, Uppsala, Sweden)
  • ヒトiPS細胞を用いたBBBモデルの構築と輸送解析への応用
    (第30回HAB研究機構学術年会 シンポジウムI「吸収・分布・排泄研究最前線」)
more...
Professional career (1):
  • Ph.D.
Work history (2):
  • 2020/04 - 現在 Teikyo University Faculty of Pharma-Science
  • 2018/07 - 2020/03 Teikyo University Faculty of Pharma-Science
Awards (1):
  • 2019/10 - 第41回 生体膜と薬物の相互作用シンポジウム 優秀発表賞 ヒトiPS細胞由来脳毛細血管内皮細胞における6-mercaptopurineの輸送機構解析
Association Membership(s) (3):
日本薬剤学会 ,  日本薬学会 ,  THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS
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