Kiyonari Shinichi

キヨナリシンイチ | Kiyonari Shinichi

Affiliation and department：
Job title：講師

Research field (2)： Tumor diagnostics and therapeutics , Tumor biology

Research keywords (5)：腫瘍生物学 , 腫瘍治療学 , 神経芽腫 , 合成致死 , MYC

Research theme for competitive and other funds (6)：

2022 - 2025 Elucidation of the folate metabolic pathway unique to neuroblastoma cells
2019 - 2022 Utilization of antimetabolite drugs for the treatment of high-risk neuroblastoma
2018 - 2020 細胞分裂期キナーゼ阻害にもとづく難治性神経芽腫の新規治療法開発
2015 - 2018 Development of new treatments for neuroblastoma based on the synthetic lethality
2015 - 2017 Mechanisms of carcinogenesis through deviation from normal development

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Papers (26)：

Ken Yamashita, Shinichi Kiyonari, Shoma Tsubota, Satoshi Kishida, Ryuichi Sakai, Kenji Kadomatsu. Thymidylate synthase inhibitor raltitrexed can induce high levels of DNA damage in MYCN-amplified neuroblastoma cells. Cancer Science. 2020. 111. 7. 2431-2439
Mayanagi K, Ishino S, Shirai T, Oyama T, Kiyonari S, Kohda D, Morikawa K, Ishino Y. Direct visualization of DNA baton pass between replication factors bound to PCNA. Scientific Reports. 2018. 8. 1. 16209-16209
Zhendong Su, Satoshi Kishida, Shoma Tsubota, Kazuma Sakamoto, Dongliang Cao, Shinichi Kiyonari, Miki Ohira, Takehiko Kamijo, Atsushi Narita, Yinyan Xu, et al. Neurocan, an extracellular chondroitin sulfate proteoglycan, stimulates neuroblastoma cells to promote malignant phenotypes. Oncotarget. 2017. 8. 63. 106296-106310
Shoma Tsubota, Satoshi Kishida, Teppei Shimamura, Miki Ohira, Satoshi Yamashita, Dongliang Cao, Shinichi Kiyonari, Toshikazu Ushijima, Kenji Kadomatsu. PRC2-Mediated Transcriptomic Alterations at the Embryonic Stage Govern Tumorigenesis and Clinical Outcome in MYCN-Driven Neuroblastoma. CANCER RESEARCH. 2017. 77. 19. 5259-5271
Hiroyuki Kitao, Shinichi Kiyonari, Makoto Iimori, Shinichiro Niimi, Yuki Kataoka, Shingo Akiyama, Keitaro Edahiro, Ryota Nakanishi, Eriko Tokunaga, Hiroshi Saeki, et al. [The Molecular Aspect of the Antitumor Effect of Oxaliplatin in Combination with 5-FU]. Gan to kagaku ryoho. Cancer & chemotherapy. 2016. 43. 6. 707-14

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MISC (4)：

Education (3)：

Professional career (1)：

Work history (7)：

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Association Membership(s) (3)：

THE JAPANESE CANCER ASSOCIATION , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPAN SOCIETY FOR BIOSCIENCE, BIOTECHNOLOGY, AND AGROCHEMISTRY

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