Research theme for competitive and other funds (6):
2021 - 2023 真の性決定遺伝子Sry-Tよる性決定の転写制御メカニズムの解明
2020 - 2023 性決定遺伝子SryがH3K9脱メチル化の標的となる機構の解明
2020 - 2022 全能性獲得における母性H3K9脱メチル化酵素の機能解析
2018 - 2020 哺乳類性決定を司る新規エピゲノム因子の探索と機構の解明
2016 - 2018 ヒストン修飾エピゲノムを介したほ乳類性決定の分子基盤
2014 - 2016 Role of H3K9 methylation and demethylation enzymes in mouse sex determination
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Papers (17):
Daiki Hashimoto, Tsuyoshi Hirashima, Hisao Yamamura, Tomoya Kataoka, Kota Fujimoto, Taiju Hyuga, Atsushi Yoshiki, Kazunori Kimura, Shunsuke Kuroki, Makoto Tachibana, et al. Dynamic erectile responses of a novel penile organ model utilizing two photon excitation microscopy (TPEM)†. Biology of Reproduction. 2021. 104. 4. 875-886
Shingo Miyawaki, Shunsuke Kuroki, Ryo Maeda, Naoki Okashita, Peter Koopman, Makoto Tachibana. The mouse Sry locus harbors a cryptic exon that is essential for male sex determination. Science. 2020. 370. 6512. 121-124
Shunsuke Kuroki, Ryo Maeda, Masashi Yano, Satsuki Kitano, Hitoshi Miyachi, Mikiko Fukuda, Yoichi Shinkai, Makoto Tachibana. H3K9 Demethylases JMJD1A and JMJD1B Control Prospermatogonia to Spermatogonia Transition in Mouse Germline. Stem cell reports. 2020. 15. 2. 424-438
Naoki Okashita, Shunsuke Kuroki, Ryo Maeda, Makoto Tachibana. TET2 catalyzes active DNA demethylation of the Sry promoter and enhances its expression. Scientific reports. 2019. 9. 1. 13462-13462
Restoring the aberrant sex development of H3K9 demethylase Jmjd1a-deficient mice by modulating H3K9 methylation balance
(Asian Sex Differentiation Network (7th Gonad Biology Joint Meeting, 2017) 2017)