Research theme for competitive and other funds (31)：
2022 - 2025 Development of a drug assay system using a miniature gut organoid model of congenital diarreal disorders
2022 - 2025 ヒト胎盤・子宮内膜細胞のゲノム空間配置解明と疾患ゲノム研究への応用
2020 - 2025 全能性獲得へのロードマップ:幹細胞のミトコンドリア・ゲノム安定性機構の解明
2021 - 2024 乳児に発症する炎症性腸疾患と造血不全の原因となる新たな単一遺伝子疾患の確立
2020 - 2024 生命発動と器官発生・制御に関わるヒト受精胚分子機序の解明
2019 - 2022 Development of a Human Taste-Small Intestine-Brain Correlation Model applying for Nutritional Physiology
2019 - 2022 Genetic alteration from in-vitro culture environment in mammalian offspring born through in vitro fertilization
2019 - 2022 Development of gene therapy for congenital adrenal hyperplasia using AAV vectors and iPS cells
2017 - 2021 Microenvironment of advanced ovarian cancer after chemotherapy
2017 - 2020 Elucidation of oocyte molecular mechanism on imprinted X chromosome inactivation enabling a sequential development
2016 - 2020 Roles of exosomes in reproductive system
2016 - 2019 Elucidation of imprinting type X chromosome inactivation mechanism of oocytes grasped from chromatin dynamics
2016 - 2019 Development of fetal treatment strategy using human ES cell preparation for liver failure model
2016 - 2019 Pathologic clarification and development of new medicine for imprinting disorders in terms of hydroxymethylation
2015 - 2019 Fetal therapy model using amniotic fluid-derived iPS cells
2015 - 2018 Effect of Octanoic acid and lipid metabolism in preembryo and pluripotent stem cells culture
2014 - 2017 Exploit of an alternative stem cell transplantation in utero based on feto-maternal tolerance using allogeneic donor cells immunologically matched to the mother.
2014 - 2017 Study for the molecular mechanism in an oocyte aging
2013 - 2017 Generation of high-quality embryonic stem cells by new reprogramming technique and a basic research for regenerative medicine
2013 - 2016 Study for defining totipotency mechanism of oocytes
2013 - 2016 molecular mechanisms of genomic rejuvenation during preimplantation development
2012 - 2015 Drug development using iPS cells derived from the dental pulp of the patients with neurodegenerative diseases, and metallothionein
2009 - 2014 Basic study to explore molecular mechanism of the oocyte effecting on developmental potential
2010 - 2012 Research for exploring totipotency of mouse zygotes
2010 - 2012 Gene cascades for starting development and generating totipotency
2008 - 2010 ヒト胚性幹(ES)細胞を生かすことができるヒトフィーダー単離システムの創成
2007 - 2010 Functional analysis of fusogenic factors related to infertility and its clinical application
2007 - 2009 精子・卵の細胞接着の分子メカニズムと生殖医療への応用
2007 - 2009 Genes expressed specifically in oocytes may have an important role in the quality (developmental competence) of oocytes
2006 - 2009 Identification of human cardiomyogenic factor
2007 - 2008 Study on a new assay for the function of mammalian spenn centrosome
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Papers (133)：
Masaya Tsukamoto, Tomoyuki Kawasaki, Mohan C Vemuri, Akihiro Umezawa, Hidenori Akutsu. A passage-free, simplified, and scalable novel method for iPSC generation in three-dimensional culture. Regenerative therapy. 2024. 27. 39-47
Robin Fears, Hidenori Akutsu, Lara Theresa Alentajan-Aleta, Andrés Caicedo, Antonio Carlos Campos de Carvalho, Miodrag Čolić, Jillian Cornish, Giulio Cossu, Patrice Debré, Geoffrey Dierckxsens, et al. Inclusivity and diversity: Integrating international perspectives on stem cell challenges and potential. Stem Cell Reports. 2021. 16. 8. 1847-1852
Junya Kojima, Atushi Fukuda, Hayato Taira, Shigehiro Hayashi, Zenta Yamanaka, Yasufumi Oishi, Kaiyu Kubota, Akihiro Umezawa, Hidenori Akutsu, Keiichi Isakal, et al. CHARACTERISTICS OF THE PLACENTAL DIFFERENTIATION PROCESS ANALYZED USING HUMAN INDUCED PLURIPOTENT STEM CELLS. PLACENTA. 2017. 57. 295-295
Mitsutoshi Yamada, Toshio Hamatani, Hidenori Akutsu, Mamoru Tanaka. Towards Further Optimization of Preimplantation Embryo Culture Media: From the Viewpoint of Omics and Somatic Cell Nuclear Transfer (SCNT) Studies. Journal of Mammalian Ova Research. 2016. 33. 1. 35-43
Hajime Uchida, Hidenori Akutsu, Akihiro Umezawa, Mureo Kasahara. Self-Organization of Fully Functional Gut Organoids from Human Pluripotent Stem Cells Under Xenogeneic-Free Conditions. TRANSPLANTATION. 2015. 99. S62-S62
2010/10 - 2020/10 Expert Panel on Bioethics of the Council for Science, Technology and Innovation (CSTI) expert committee member
Association Membership(s) (4)：
The Japanese Society for Regenerative Medicine
, Japan Society for Reproductive Medicine
, The International Society for Stem Cell Research (ISSCR)
, Japan Society of Obstetrics and Gynecology
