Research field (3):
Obstetrics and gynecology
, Otorhinolaryngology
, Immunology
Research keywords (4):
癌・精巣抗原
, 抗精子抗体
, 糖鎖
, GPIアンカー型タンパク質
Research theme for competitive and other funds (10):
2022 - 2025 Ontogeny of the mammalian oviduct: a metabolomic analysis of the effects of its microenvironment on the fertilized egg
2021 - 2024 糖鎖伸長抑制因子「バイセクト型糖鎖」の雄性生殖細胞分化制御能の解析
2017 - 2019 多形核白血球の挙動から見る女性の生理学的特性:細胞レベルに性差はあるか?
2016 - 2019 糖鎖工学及び免疫学的手法を用いたバイセクト型糖鎖の生殖生物学的機能解明
2013 - 2016 IgG4関連疾患の病態の解明と新規分子を標的とした治療戦略の新展開
2012 - 2015 癌・精巣抗原TEX101を分子標的とした頭頸部癌ミサイル療法の開発
2009 - 2012 癌関連抗原TEX101の頭頸部癌細胞浸潤制御能及びその臨床応用に関する検討
2009 - 2011 神経反発因子セマフォリ3Aを用いた斬新で画期的なアレルギー性鼻炎治療の研究
2006 - 2009 遺伝子導入を用いた生殖細胞特異抗原TEX101の性腺形成制御機構の解析
2004 - 2006 アレルギー性鼻炎におけるエピジェネティクな遺伝子発現機構の解析
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Papers (50):
Kenji Yamatoya, Masaru Kurosawa, Michiko Hirose, Yoshiki Miura, Hikari Taka, Tomoyuki Nakano, Akiko Hasegawa, Kyosuke Kagami, Hiroshi Yoshitake, Kaoru Goto, et al. The fluid factor OVGP1 provides a significant oviductal microenvironment for the reproductive process in golden hamster. Biology of Reproduction. 2023
Kenji Yamatoya, Masaru Kurosawa, Michiko Hirose, Yoshiki Miura, Hikari Taka, Tomoyuki Nakano, Akiko Hasegawa, Kyosuke Kagami, Hiroshi Yoshitake, Kaoru Goto, et al. OVGP1 is an oviductal fluid factor essential particularly for early embryonic development in golden hamsters. 2022
Fujiro Sendo, Hiroshi Yoshitake, Yoshihiko Araki. Targeting of neutrophil activation in the early phase of the disease for prevention of Coronavirus disease-19 severity. Microbiology and Immunology. 2022. 66. 6. 264-276
Yoshihiko Araki, Hiroshi Yoshitake, Kenji Yamatoya, Hiroshi Fujiwara. An overview of sex and reproductive immunity from an evolutionary/anthropological perspective. Immunological medicine. 2020. 1-7
Hiroshi Yoshitake, Yoshihiko Araki. Role of the Glycosylphosphatidylinositol-Anchored Protein TEX101 and Its Related Molecules in Spermatogenesis. International journal of molecular sciences. 2020. 21. 18
Oda Risako, Yoshitake Hiroshi, Hasegawa Akiko, Araki Yoshihiko. The morphological expression of an oligosaccharide chain with bisecting N-acetylglucosamine recognized by anti-sperm auto-monoclonal antibody, Ts4, in mouse germ and somatic cells. JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2016. 118. 139
Yoshitake Hiroshi, Arii Daisuke, Hamamura Kensuke, Matsuda Hironori, Sakuraba Mayumi, Kawasaki Yu, Takamori Kenji, Takeda Yuji, Sendo Fujiro, Fujiwara Hiroshi, et al. Sexual differences and cellular diversity of rat peripheral polymorphonuclear leukocytes monitored with a monoclonal antibody, RP-3. Journal of Reproductive Immunology. 2016. 118. 123
The stability of TEX101/Ly6k complexes is maintained by both factors during biosynthesis in testicular germ cells.
(48th Annual Meeting of the Society for the Study of Reproduction 2015)
Structure of the oligosaccharide chain in the molecular epitope for an anti-sperm auto-monoclonal antibody, Ts4.
(46th Annual Meeting of the Society for the Study of Reproduction 2013)
Molecular expression of Ly6k, a putative glycosylphosphatidylinositol-anchored membrane protein on the testicular germ cells.
(43th Annual Meeting of the Society for the Study of Reproduction 2010)
Molecular characterization and expression of alpha-N-acetyl glucosaminidase, a potential target molecule recognized with an Anti-sperm Auto-monoclonal Antibody, Ts4.
(43th Annual Meeting of the Society for the Study of Reproduction 2010)
1998 - 2002 Yamagata University Graduate School of Medical Science
1990 - 1996 Yamagata University Faculty of Medicine School of Medicine
Professional career (1):
博士(医学) (山形大学)
Work history (5):
2013/11 - 現在 Juntendo University
2012/04 - 2013/10 Nippon Medical School
2007/04 - 2012/03 Juntendo University
2005/04 - 2007/03 Juntendo University
2004/04 - 2005/03 Yamagata University Faculty of Medicine
Committee career (1):
2012 - 現在 日本生殖免疫学会 評議員
Association Membership(s) (6):
Society for the Study of Reproduction
, THE JAPANESE ASSOCIATION OF ANATOMISTS
, JAPANESE SOCIETY OF ALLERGOLOGY
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, JAPAN SOCIETY FOR IMMUNOLOGY OF REPRODUCTION
, THE OTO-RHINO-LARYNGOLOGICAL SOCIETY OF JAPAN