Yoshida Takashi

Affiliation and department：
Job title：准教授

Research field (1)： Cell biology

Research theme for competitive and other funds (9)：

2023 - 2026 近赤外光活性化人工チャネルの創生による抗がん治療法の開発
2020 - 2025 細胞種ごとに異なる発現パターンを示す小胞体内イオン輸送体の生理学的意義の解明
2018 - 2023 The development of regulatory methods for osteocyte function using optogenetics
2015 - 2018 The development of light-activatable proteins for inducing mechanical stimulation in the cells
2015 - 2018 Pathophysiological analysis of oral diseases caused by dysregulation of cation channels

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Papers (19)：

Shinichiro Yamamoto, Naoto Kiyatake, Akihiro Kaneko, Masanao Shimamura, Takashi Yoshida, Shunichi Shimizu. Mouse transient receptor potential melastatin 2 (TRPM2) isoform 7 attenuates full-length mouse TRPM2 activity through reductions in its expression by targeting it to ER-associated degradation. Genes to cells : devoted to molecular & cellular mechanisms. 2024
Kaori Takahashi, Takashi Yoshida, Minoru Wakamori. Periodontal Ligaments Enhance Neurite Outgrowth in Trigeminal Ganglion Neurons through Wnt5a Production Induced by Mechanical Stimulation. American Journal of Physiology-Cell Physiology. 2022
Chenyao Wang, Shin-ichiro Horigane, Minoru Wakamori, Shuhei Ueda, Takeshi Kawabata, Hajime Fujii, Itaru Kushima, Hiroki Kimura, Kanako Ishizuka, Yukako Nakamura, et al. Identification of ultra-rare disruptive variants in voltage-gated calcium channel-encoding genes in Japanese samples of schizophrenia and autism spectrum disorder. Translational Psychiatry. 2022. 12. 1
Masayuki Izumi, Takashi Yoshida, Takashi Nakamura, And Minoru Wakamori. Paeonol, an Ingredient of Kamishoyosan, Reduces Intracellular Lipid Accumulation by Inhibiting Glucocorticoid Receptor Activity in 3T3-L1 Cells. Nutrients. 2020. 12. 2
Ryo Shinotsuka, Toru Oba, Takahiro Mitome, Takuto Masuya, Satoshi Ito, Yukie Murakami, Tomoko Kagenishi, Yutaka Kodama, Masaru Matsuda, Takashi Yoshida, et al. Synthesis of quinolyl-pyrrole derivatives as novel environment-sensitive fluorescent probes. Journal of Photochemistry and Photobiology A: Chemistry. 2019. 382. 111900-111900

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MISC (19)：

高橋かおり, 吉田卓史, 中村卓史, 若森実. 三叉神経中脳路核における機械刺激負荷歯根膜細胞由来Wnt5aの役割. Journal of Oral Biosciences Supplement. 2023. 2023. [O3-01]
吉田卓史, 高橋かおり, 中村卓史, 若森実. 亜鉛によるMC3T3-E1細胞分化亢進作用におけるカルシウム依存性カリウムチャネルの役割. Journal of Oral Biosciences Supplement. 2018. 2018. 450-450
Takashi Yoshida, Kaori Takahashi, Minoru Wakamori. The inhibitory mechanism of eugenol on TRPV1 channel. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2014. 124. 175P-175P
Takashi Yoshida, Kaori Takahashi, Takashi Kikuchi, Minoru Wakamori. The inhibitory mechanism of eugenol on TRPV1 channel. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 171P-171P
Nobuaki Takahashi, Takashi Yoshida, Shinichiro Yamamoto, Yoshifumi Ueda, Yasuo Mori. Spatio-temporal regulation of intracellular Ca2+ and NO signaling by the TRPC5 channel complex. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S196-S196

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Lectures and oral presentations (15)：

一酸化窒素のシステイン残基直接酸化修飾によるTRPチャネル活性化機構
(第49回歯科基礎医学会学術大会 2007)
一酸化窒素によるニトロシル化を介したTRP チャンネル活性化
(第84回日本生理学会大会 2007)
NOによるニトロシル化を介したTRPチャネル活性化とそのシグナル統合における意義
(細胞シグナリングの時空間統御機構解明への方略探索 2006)
Nitric-oxide directly activates TRP channels via oxidative cysteine modification
(20th IUBMB International Congress of Biochemistry and Molecular biology 2006)
TRPチャネル拮抗剤による新規修飾方法の開発
(第2回TRPチャネル研究会 2006)

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