Rchr
J-GLOBAL ID：201801004371800585   Update date: Jan. 22, 2025

Heishima Kazuki

ヘイシマ カズキ | Heishima Kazuki
Affiliation and department：
Gifu University

About Gifu University


Job title： G-YLC (the Young Leaders Cultivating program)-designated assistant professor
Other affiliations (3)：
Research field  (4)： Experimental pathology ,  Molecular biology ,  Tumor biology ,  Veterinary medicine
Research keywords  (10)： 種間比較アプローチ ,  比較代謝学 ,  ペタシン ,  Mitochondrial metabolism ,  Cancer metabolism ,  マルチオミクス解析 ,  Histopathology ,  Cancer Biology ,  Comparative Oncology ,  MicroRNA
Research theme for competitive and other funds  (4)：
  • 2022 - 2025 N/A
  • 2021 - 2023 N/A
  • 2021 - 2022 高活性ミトコンドリア呼吸鎖複合体I阻害剤であるペタシンの標的分子の同定
  • 2020 - 2022 Development of miR-143-lipid nanoparticle-based therapy against KRAS-mutant multiple myeloma
Papers (44)：
  • Shingo Minatoguchi, Nobuhiko Sugito, Kazuki Heishima, Yuko Ito, Remi Nakashima, Hiroyuki Okura, Yukihiro Akao, Shinya Minatoguchi. Restoration effect of chemically modified microRNA-143-3p on acute myocardial infarction in animal models. Scientific Reports. 2025. 15. 1
  • Hirotaka Murase, Shingo Minatoguchi, Kazuki Heishima, Shinji Yasuda, Atsushi Satake, Ryo Yoshizumi, Hisaaki Komaki, Shinya Baba, Shinsuke Ojio, Toshiki Tanaka, et al. Plasma microRNA-143 and microRNA-145 levels are elevated in patients with left ventricular dysfunction. Heart and vessels. 2024
  • Hemangiosarcoma in dogs as a potential non-rodent animal model for drug discovery research of angiosarcoma in humans. Frontiers in Oncology. 2023. 13
  • Jun Arima, Kohei Taniguchi, Nobuhiko Sugito, Kazuki Heishima, Yoshihisa Tokumaru, Yosuke Inomata, Kazumasa Komura, Tomohito Tanaka, Masa-Aki Shibata, Sang-Woong Lee, et al. Antitumor effects of chemically modified miR-143 lipoplexes in a mouse model of pelvic colorectal cancer via myristoylated alanine-rich C kinase substrate downregulation. Molecular Therapy - Nucleic Acids. 2023. 34. 102079-102079
  • Kazuki Heishima, Nobuhiko Sugito, Chikara Abe, Akihiro Hirata, Hiroki Sakai, Yukihiro Akao. Targeting microRNA-145-mediated progressive phenotypes of early bladder cancer in a molecularly defined in vivo model. Molecular Therapy - Nucleic Acids. 2023. 33. 960-982
ｍore...
MISC (3)：
Patents (2)：
  • 血管病変の評価方法および血管病変評価用キット
  • 腫瘍細胞におけるアスパラギン酸合成の阻害剤、腫瘍細胞のスフェロイド形成阻害剤、腫瘍細胞の転移抑制剤、解糖系阻害剤の作用増強剤、並びに腫瘍の転移の抑制および/または予防用医薬組成物
Books (1)：
  • 犬腫瘍における血漿中microRNA-214およびmicroRNA-126発現量の検索
    文永堂出版 2016
Lectures and oral presentations  (39)：
  • 種間共通の代謝を標的とする新たな抗がん戦略の開発
    (獣医学特別セミナー(山口大学) 2024)
  • Investigation of the roles of histone lactylation and metabolic features in canine hemangiosarcoma
    (The 83th Annual Meeting of the Japanese Cancer Association 2024)
  • 動物用医薬品開発を考える
    (動物用医薬品開発検討WG 2024)
  • Impact of interaction with patients through crowdfunding on a young researcher
    (ARO協議会第10回学術集会 2023)
  • Analyses of Roles of Histone Lactylation and Glucose Metabolism in Canine Hemangiosarcoma
    (International Society of Organoid Research 2023 2023)
ｍore...
Education (2)：
  • 2013 - 2016 Gifu University
  • 2007 - 2013 Iwate University Veterinary Medicine
Professional career (1)：
  • 博士(獣医学) (岐阜大学)
Work history (10)：
  • 2024/09 - 現在 ルーベン・カトリック大学(ベルギー) フランダースバイオテクノロジー研究機関がん生物研究所 客員研究員
  • 2023/04 - 現在 Gifu University Institute for Advanced Study, Center for One Medicine Innovative Translational Research Assistant Professor
  • 2022/04 - 現在 Nagoya University Institute for Advanced Research
  • 2022/04 - 現在 Gifu University
  • 2022/04 - 現在 Hokkaido University
Show all
Committee career (1)：
  • 2024/02 - 現在 Veterinary and Comparative Oncology Editorial Board
Awards (6)：
  • 2023/01 - Global Young Scientist Symposium 2023 Japan Science and Technology Agency-designated Participant for Global Young Scientist Symposium 2023
  • 2022/08 - Mansfield-PhRMA Research Program Scholar
  • 2022/04 - Tokai Pathways to Global Excellence (T-GEx) Fellow
  • 2016/02 - 日本獣医内科学アカデミー(JCVIM) 研究アワード
  • 2015/09 - 北海道大学 Best Poster Presentation Award (The 3rd SaSSOH)
Show all
Association Membership(s) (5)：
日本毒性病理学会 ,  JAPANESE SOCIETY FOR RADIATION ONCOLOGY ,  Veterinary Cancer Society ,  THE JAPANESE SOCIETY OF VETERINARY SCIENCE ,  THE JAPANESE CANCER ASSOCIATION
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