Yasunaga Masahiro

Research field (2)： Clinical pharmacy , Tumor diagnostics and therapeutics

Research keywords (5)： Next generation biopharmaceutical , Immunoregulation , Molecular imaging , Drug delivery system , Antibody therapeutics

Research theme for competitive and other funds (11)：

2020 - 2023 二重特異性がん治療抗体の革新的プロドラッグ化デザインの開発
2019 - 2023 Investigation on relationship between glycan structure and antibody-drug conjugate function
2018 - 2023 難治性固形癌予後改善に資する間質バリアを克服するための新規放射免疫療法戦略の開発
2020 - 2022 Decvelopment of immune targeting as a new DDS concept for autoimmune diseases
2018 - 2021 Creating a pharmacological evaluation system using a highly sensitive single cell ESI-MS analysis for the development of innovative new drugs.

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Papers (139)：

Shigehiro Koganemaru, Hirobumi Fuchigami, Daiki Yamashita, Chihiro Morizono, Hironori Sunakawa, Akihito Kawazoe, Yoshiaki Nakamura, Yasutoshi Kuboki, Kohei Shitara, Tomonori Yano, et al. Quantitative analysis of the concentration of FTD in tumor hypoxic regions using a novel platform combining functional endoscopy and mass spectrometry. Clinical pharmacology and therapeutics. 2023
Shota Fukuoka, Yoshikatsu Koga, Mayumi Yamauchi, Shigehiro Koganemaru, Masahiro Yasunaga, Kohei Shitara, Toshihiko Doi, Takayuki Yoshino, Toshio Kuronita, Brian Elenbaas, et al. p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab. Scientific reports. 2023. 13. 1. 16017-16017
高島大輝, 大貫和信, 眞鍋史乃, 古賀宣勝, 津村遼, 安西高廣, Yin Xiaojie, 羽場宏光, 藤井博史, 安永正浩. 能動的標的化を維持管理することがα線放出核種アスタチン-211結合抗体の薬効を最大化するために重要である. 日本DDS学会学術集会プログラム予稿集. 2023. 39回. 171-171
Methanee Hiranyakorn, Shogo Iwamoto, Asako Hoshinoo, Ryo Tsumura, Hiroki Takashima, Masahiro Yasunaga, Shino Manabe. Chromatographic Analysis of the N-Glycan Profile on Therapeutic Antibodies Using FcγRIIIa Affinity Column Chromatography. ACS Omega. 2023. 8. 18. 16513-16518
Ryo Tsumura, Miwa Haruta, Masataka Kuwano, Masahiro Yasunaga. Expansion of mixed immune cells using CD3/CD161 co-stimulation for the treatment of cancer. Scientific reports. 2023. 13. 1. 6803-6803

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MISC (344)：

笹部真亜沙, 高島健司, 坂下信悟, 古賀宣勝, 安西高廣, YANG Shiqi, 西條信史, 田中英基, 依田雄介, 安永正浩, et al. ヒト化抗EpCAM抗体を用いた食道胃接合部腺癌に対する光免疫療法の検討. 日本消化器病学会雑誌(Web). 2023. 120
多田有花, 多田有花, 安西高廣, 津村遼, 阿部由督, 安永正浩. リサイクリング機能に着目した抗体DDS製剤の開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
東哲平, 東哲平, 高島大輝, 安西高廣, 津村遼, 船坂知華子, 安永正浩, 安永正浩. 血液脳関門が抗体の送達に与える影響の解析. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
松本宗大, 松本宗大, YANG Shiqi, YANG Shiqi, 安西高廣, 津村遼, 安永正浩. 1型糖尿病におけるIL-7R標的ADC(Antibody-drug conjugate)の開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
東哲平, 東哲平, 高島大輝, 安西高廣, 津村遼, 船坂知華子, 安永正浩, 安永正浩. Analysis of the effect of the blood-brain barrier on antibody delivery into brain tumors. 日本癌学会学術総会抄録集(Web). 2023. 82nd

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Education (3)：

1992 - 1996 Kumamoto university Graduate school of medicine
1993 - 1995 Kyoto University Graduate School of Medicine Molecular genetics
1982 - 1988 Kumamoto university School of medicine

Work history (13)：

2021/04 - 現在 Kumamoto University Graduate School of Medical Sciences Medical Oncology and Translational Research Visiting Professor
2021/04 - 現在 Tokyo Medical and Dental University Life Science and Technology Track NCC Cancer Science Visiting Professor
2020/06 - 現在 National Cancer Center Exploratory Oncology Research and Clinical Trial Center, Division of Developmental Therapeutics Chief
2015/04 - 現在 The University of Tokyo, Graduate School of Frontier Sciences Department of Integrated Biosciences, Laboratory of Cancer Biology Visiting Professor
2013/04 - 現在 Tokyo Medical and Dental University Life Science and Technology Track, NCC Cancer Science Associate Professor (Cooperative Graduate School Program)

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