Yasunaga Masahiro

Research field (2)： Clinical pharmacy , Tumor diagnostics and therapeutics

Research keywords (5)： Next generation biopharmaceutical , Immunoregulation , Molecular imaging , Drug delivery system , Antibody therapeutics

Research theme for competitive and other funds (11)：

2020 - 2023 二重特異性がん治療抗体の革新的プロドラッグ化デザインの開発
2019 - 2023 Investigation on relationship between glycan structure and antibody-drug conjugate function
2018 - 2023 難治性固形癌予後改善に資する間質バリアを克服するための新規放射免疫療法戦略の開発
2020 - 2022 Decvelopment of immune targeting as a new DDS concept for autoimmune diseases
2018 - 2021 Creating a pharmacological evaluation system using a highly sensitive single cell ESI-MS analysis for the development of innovative new drugs.

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Papers (144)：

Ryo Tsumura, Takahiro Anzai, Yoshikatsu Koga, Hiroki Takashima, Yasuhiro Matsumura, Masahiro Yasunaga. Anti-tissue factor antibody conjugated with monomethyl auristatin E or deruxtecan in pancreatic cancer models. Cancer science. 2024
Tomohiro Fujii, Kenichiro Ito, Kazutoshi Takahashi, Tsubasa Aoki, Rika Takasugi, Takuya Seki, Yusuke Iwai, Tomohiro Watanabe, Ryusuke Hirama, Ryo Tsumura, et al. Bispecific Antibodies Produced via Chemical Site-Specific Conjugation Technology: AJICAP Second-Generation. ACS medicinal chemistry letters. 2023. 14. 12. 1767-1773
Shigehiro Koganemaru, Hirobumi Fuchigami, Daiki Yamashita, Chihiro Morizono, Hironori Sunakawa, Akihito Kawazoe, Yoshiaki Nakamura, Yasutoshi Kuboki, Kohei Shitara, Tomonori Yano, et al. Quantitative analysis of the concentration of FTD in tumor hypoxic regions using a novel platform combining functional endoscopy and mass spectrometry. Clinical pharmacology and therapeutics. 2023. 115. 1. 62-70
笹部真亜沙, 高島健司, 坂下信悟, 古賀宣勝, 安西高廣, Yang Shiqi, 西條信史, 田中英基, 依田雄介, 安永正浩, et al. ヒト化抗EpCAM抗体を用いた食道胃接合部腺癌に対する光免疫療法の検討. 日本消化器病学会雑誌. 2023. 120. 臨増大会. A750-A750
Shota Fukuoka, Yoshikatsu Koga, Mayumi Yamauchi, Shigehiro Koganemaru, Masahiro Yasunaga, Kohei Shitara, Toshihiko Doi, Takayuki Yoshino, Toshio Kuronita, Brian Elenbaas, et al. p70S6K/Akt dual inhibitor DIACC3010 is efficacious in preclinical models of gastric cancer alone and in combination with trastuzumab. Scientific reports. 2023. 13. 1. 16017-16017

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MISC (346)：

高島大輝, 津村遼, 古賀宣勝, 安西高廣, YIN Xiaojie, 佐藤望, 重河優大, 南部明弘, 臼田祥子, 羽場宏光, et al. 放射線分解がα線放出核種アスタチン-211標識抗体の薬理薬効に及ぼす影響. 日本抗体学会学術大会プログラム・抄録集(Web). 2023. 2nd
眞鍋史乃, 眞鍋史乃, 高島大輝, 羽場宏光, 安永正浩, 藤井博史. Trial for alpha therapy by fusion of organic chemistry, medicinal science, and nuclear chemistry. 日本薬学会年会要旨集(Web). 2023. 143rd
笹部真亜沙, 高島健司, 坂下信悟, 古賀宣勝, 安西高廣, YANG Shiqi, 西條信史, 田中英基, 依田雄介, 安永正浩, et al. ヒト化抗EpCAM抗体を用いた食道胃接合部腺癌に対する光免疫療法の検討. 日本消化器病学会雑誌(Web). 2023. 120
多田有花, 多田有花, 安西高廣, 津村遼, 阿部由督, 安永正浩. リサイクリング機能に着目した抗体DDS製剤の開発. 日本DDS学会学術集会プログラム予稿集. 2023. 39th
東哲平, 東哲平, 高島大輝, 安西高廣, 津村遼, 船坂知華子, 安永正浩, 安永正浩. 血液脳関門が抗体の送達に与える影響の解析. 日本DDS学会学術集会プログラム予稿集. 2023. 39th

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Education (3)：

1992 - 1996 Kumamoto university Graduate school of medicine
1993 - 1995 Kyoto University Graduate School of Medicine Molecular genetics
1982 - 1988 Kumamoto university School of medicine

Work history (13)：

2021/04 - 現在 Kumamoto University Graduate School of Medical Sciences Medical Oncology and Translational Research Visiting Professor
2020/06 - 現在 National Cancer Center Exploratory Oncology Research and Clinical Trial Center, Division of Developmental Therapeutics Chief
2015/04 - 現在 The University of Tokyo, Graduate School of Frontier Sciences Department of Integrated Biosciences, Laboratory of Cancer Biology Visiting Professor
2021/04 - 2024/03 Tokyo Medical and Dental University Life Science and Technology Track NCC Cancer Science Visiting Professor
2013/04 - 2021/03 Tokyo Medical and Dental University Life Science and Technology Track, NCC Cancer Science Associate Professor (Cooperative Graduate School Program)

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