2017 - 2020 Analysis of acquisition of metastasis property by p53 LOH and heterogeneity of tumor cells in CRC mouse model
2014 - 2017 Model mouse for malignant colorectal cancer progression
2012 - 2015 The role of inflammatory responses and tumor immunity in tumor development
Papers (30)：
Dong Wang, Mizuho Nakayama, Chang Pyo Hong, Hiroko Oshima, Masanobu Oshima. Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling-Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors. Cancer research. 2024. 84. 1. 56-68
Sau Yee Kok, Mizuho Nakayama, Atsuya Morita, Hiroko Oshima, Masanobu Oshima. Genetic and nongenetic mechanisms for colorectal cancer evolution. Cancer science. 2023. 114. 9. 3478-3486
Satoshi Arai, Hideki Itoh, Cong Quang Vu, Mizuho Nakayama, Masanobu Oshima, Atsuya Morita, Kazuko Okamoto, Satoru Okuda, Aki Teranishi, Madori Osawa, et al. qMaLioffG: A single green fluorescent protein FLIM indicator enabling quantitative imaging of endogenous ATP. 2023
Atsuya Morita, Mizuho Nakayama, Dong Wang, Kazuhiro Murakami, Masanobu Oshima. Frequent loss of metastatic ability in subclones of Apc , Kras , Tgfbr2 , and Trp53 mutant intestinal tumor organoids. Cancer Science. 2023
Atsuya Morita, Mizuho Nakayama, Hiroko Oshima, Masanobu Oshima. In Vitro and In Vivo Models for Metastatic Intestinal Tumors Using Genotype-Defined Organoids. Methods in molecular biology (Clifton, N.J.). 2023. 2691. 19-30
