Mikihito Kajiya

カジヤミキヒト | Mikihito Kajiya

Affiliation and department：
Job title： Professor

Research field (2)： Regenerative dentistry and dental engineering , Conservative dentistry and endodontics

Research theme for competitive and other funds (29)：

2023 - 2026 バイオ3Dプリンタで作製した三次元移植組織を用いる革新的歯周再生療法の開発
2022 - 2026 Systemic understanding about epigenetic regulatory mechanism focused on bone remodeling
2022 - 2025 集塊培養技術によるiPS細胞由来顎骨・歯肉オルガノイドの樹立と口腔再生医学の深化
2021 - 2024 Challenge for analyzing the dysfunctional mechanism of oral barrier repair via dioxin receptor due to smoking
2022 - 2023 間葉系幹細胞集塊から作製する骨様組織を用いた骨再生細胞製剤販売事業~人にも動物にも最高の骨再生医療を~

2021 - 2022 細胞集塊培養技術によって得られる人工材料不含の骨様組織を用いた顎骨再建療法事業化検証

2019 - 2022 創薬スクリーニングによるNR4A1を標的にした薬物性歯肉増殖症の治療薬の探索

2019 - 2022 立体間葉系幹細胞集塊と軟骨誘導を利用した他家移植歯周組織再生療法開発

2020 - 2022 新たな手法を用いた肝炎ウイルス検査受験率・陽性者受診率の向上に資する研究

2020 - 2021 三次元間葉系幹細胞集塊からの骨オルガノイド創生とそれを用いた革新的骨再生医療開発

2018 - 2021 MMD2変異マウスを用いた侵襲性歯周炎の病態解明

2018 - 2021 神経堤細胞由来間葉系幹細胞と細胞集塊培養技術を用いた新規歯周組織再生療法開発

2019 - 2020 Development of periodontal tissue regenerative therapy by clumps of mesenchymal stem cells/extracellular matrix complexes

2018 - 2020 iPS細胞由来間葉系幹細胞と集塊培養技術を応用した歯周組織再生細胞製剤の開発

2019 - 2020 3次元間葉系幹細胞集塊のYAP/TAZメカノトランスダクション制御による骨オルガノイドの創生

2017 - 2019 Development of new periodontal tissue regeneration therapy using cartilage induced clumps of mesenchymal stem cells

2017 - 2019 立体培養間葉系幹細胞集塊の細胞分化を制御するメカノトランスダクション機構の解析

2016 - 2019 NR4A1を標的とした薬物性歯肉増殖症の新しい治療法開発のための基礎研究

2017 - 2018 三次元間葉系幹細胞集塊を応用した骨再生細胞製剤の開発

2017 - 2018 間葉系幹細胞集塊C-MSCを細胞製剤として供給する新規骨組織再生療法の開発

2015 - 2018 球状骨髄間葉系幹細胞集塊から3D構築された立体組織移植による歯周組織再生療法開発

2015 - 2018 家族性侵襲性歯周炎の関連遺伝子同定と病態解析

2015 - 2018 歯肉上皮細胞機能制御による歯周病原細菌全身移行への抑制効果の検討

2018 - 2018 立体間葉系幹細胞集塊を利用した歯周組織再生細胞製剤開発

2014 - 2016 間葉系幹細胞集塊clumps-MSCsによる歯周組織再生療法の開発

2014 - 2015 間葉系幹細胞集塊Clumps of MSCs/ECM complexを用いた他家細胞移植骨組織再生療法の開発

2013 - 2014 骨髄間葉系幹細胞の抗炎症作用を利用した歯周病細胞治療法の確立

2012 - 2014 低分子リガンドによるTrkBトランスアクチベーションを用いた歯周組織再生療法開発

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Papers (123)：

Tomoya Ueda, Shinji Matsuda, Yurika Ninomiya, Fuminori Nakashima, Keisuke Yasuda, Daisuke Furutama, Takumi Memida, Tetsuya Yoshimoto, Mikihito Kajiya, Kouji Ohta, et al. Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement. BioFactors (Oxford, England). 2024
Hiromi Nishi, Mikihito Kajiya, Kouji Ohta, Hideo Shigeishi, Taiji Obayashi, Syuichi Munenaga, Nami Obayashi, Yukio Yoshioka, Masaru Konishi, Takako Naruse, et al. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan. Scientific reports. 2024. 14. 1. 11114-11114
Kazuhisa Ouhara, Tasuku Takemura, Yuri Taniguchi, Ryousuke Fujimori, Tetsuya Tamura, Yuki Akane, Shinji Matsuda, Yuta Hamamoto, Tomoaki Shintani, Mikihito Kajiya, et al. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral diseases. 2024
Shunsuke Miyauchi, Kazuhisa Ouhara, Tomoaki Shintani, Takehito Tokuyama, Yousaku Okubo, Sho Okamura, Shogo Miyamoto, Naoto Oguri, Yukimi Uotani, Tasuku Takemura, et al. Periodontal Treatment During the Blanking Period Improves the Outcome of Atrial Fibrillation Ablation. Journal of the American Heart Association. 2024. 13. 8. e033740
Pan Gao, Mikihito Kajiya, Souta Motoike, Makoto Ikeya, Jingmei Yang. Application of mesenchymal stem/stromal cells in periodontal regeneration: Opportunities and challenges. The Japanese dental science review. 2024. 60. 95-108

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MISC (6)：

Development of Cytokine Therapy with BDNF (brain-derived neurotrophic factor) for Periodontal Tissue Regeneration. 2015. 11. 1. 16-28
Kajiya M, Kittaka M, Shiba H, Takewaki M, Takeshita K, Iwata T, Ouhara K, Takeda K, Fujita T, Kurihara H. P-57 Clumps of mesenchymal stem cells/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration. The journal of the Japanese Society for Dental Materials and Devices. 2014. 33. 5. 462-462
Takeda K, Konishi A, Kajiya M, Matsuda S, Fujita T, Shiba H, Kurihara H. P-5 Brain-derived neurotrophic factor/hyaluronic acid complex enhances periodontal tissue regeneration. The journal of the Japanese Society for Dental Materials and Devices. 2014. 33. 5. 391-391
SHIBA Hideki, TAKEDA Katsuhiro, OUHARA Kazuhisa, KAJIYA Mikihito, FUJITA Tsuyoshi, MIZUNO Noriyoshi, HINO Takamune, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Effects of LL37 on expression of inflammatory cytokines in human pulp cells. 2008. 29. 3. 147-154
TSUDA Hidehiro, SHIBA Hideki, KAJIYA Mikihito, FUJITA Tsuyoshi, TAKEDA Katsuhiro, MIZUNO Noriyoshi, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Nd:YAG laser irradiation abolishes peptidoglycan-induced increment in IL-6 and IL-8 through p38 signaling pathway in human pulp cells. 2007. 50. 32-32

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Patents (1)：

MAPK inhibition by H2

Lectures and oral presentations (11)：

Symposium: Development of Periodontal Tissue Regenerative Therapy Using Mesenchymal Stem Cells and Bio-3D Printer
(AADOCR Florida-JSPS joint Symposium 2024)
シンポジウム自家間葉系幹細胞とバイオ3Dプリンタを用いた歯周組織再生療法の実用化への展望
(東京都医工連携HUB機構「アカデミア発、医工連携ベンチャーの最前線」 2023)
シンポジウム歯科金属アレルギー診療指針に向かう道標
(日本補綴歯科学会第132回学術大会-設立90周年記念大会- 2023)
Symposium "New Avenues for Regenerative Medicine Opened by 3D Cell Clumps Culture Techniques and Nanodevices"
(The 7th International symposium on biomedical engineering (ISBE2022) 2022)
Focused learning sessions "Clumps of Mesenchymal Stem Cell for Periodontal Tissue Regeneration"
(2021 IADR/AADR/CADR General Session & Exhibition 2021)

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Education (2)：

2005 - 2009 Hiroshima University Graduate School of Biomedical Sciences
1999 - 2005 Hiroshima University Faculty of Dentistry

Work history (7)：

2022/05 - 現在広島大学ナノデバイス研究所教授(併任)
2022/04 - 現在 Department of Innovation & Precision Dentistry, Graduate School of BIomedical and Health Sciences, Hiroshima University Professor
2022/04 - 現在 Center for oral clinical examination, Hiroshima University Hospital Professor
2017/05 - 2022/03 Hiroshima University Graduate School of Biomedical Sciences
2012/05 - 2017/04 広島大学病院口腔維持修復歯科歯周診療科助教

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Awards (7)：

2020/10 - 日本歯周病学会日本歯周病学会学術賞
2015 - 日本歯科保存学会日本歯科保存学会奨励賞
2011 - Hiroshima Conference on Education and Science in Dentistry Best poster award
2009 - 広島大学歯学部同窓会奨励賞
2009 - 日本歯周病学会日本歯周病学会奨励賞

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Association Membership(s) (8)：

JAPANESE SOCIETY OF PERIODONTOLOGY , THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY , JAPAN ENDODONTIC ASSOCIATION , 国際歯科研究学会 , 日本歯科基礎医学会 , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , 日本口腔検査学会

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