Mikihito Kajiya

カジヤミキヒト | Mikihito Kajiya

Affiliation and department：
Job title： Professor

Research field (2)： Regenerative dentistry and dental engineering , Conservative dentistry and endodontics

Research theme for competitive and other funds (30)：

2024 - 2027 Deciphering the regulatory mechanism of cancer microenvironment induced by disruption of the Hippo pathway and novel therapeutic approach
2023 - 2026 バイオ3Dプリンタで作製した三次元移植組織を用いる革新的歯周再生療法の開発
2022 - 2026 Systemic understanding about epigenetic regulatory mechanism focused on bone remodeling
2022 - 2025 集塊培養技術によるiPS細胞由来顎骨・歯肉オルガノイドの樹立と口腔再生医学の深化
2021 - 2024 Challenge for analyzing the dysfunctional mechanism of oral barrier repair via dioxin receptor due to smoking

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Papers (130)：

Toshinori Ando, Kento Okamoto, Yume Ueda, Nanako Kataoka, Tomoaki Shintani, Souichi Yanamoto, Mutsumi Miyauchi, Mikihito Kajiya. YAP/TAZ interacts with RBM39 to confer resistance against indisulam. Oncogenesis. 2024. 13. 1. 25-25
Fuminori Nakashima, Shinji Matsuda, Yurika Ninomiya, Tomoya Ueda, Keisuke Yasuda, Saki Hatano, Shogo Shimada, Daisuke Furutama, Takumi Memida, Mikihito Kajiya, et al. Role of sclerostin deletion in bisphosphonate-induced osteonecrosis of the jaw. Bone. 2024. 117200-117200
Tomoya Ueda, Shinji Matsuda, Yurika Ninomiya, Fuminori Nakashima, Keisuke Yasuda, Daisuke Furutama, Takumi Memida, Tetsuya Yoshimoto, Mikihito Kajiya, Kouji Ohta, et al. Nuclear receptor 4A1 (NR4A1) upregulated by n-butylidenephthalide via the mitogen-activated protein kinase (MAPK) pathway ameliorates drug-induced gingival enlargement. BioFactors (Oxford, England). 2024
Hiromi Nishi, Mikihito Kajiya, Kouji Ohta, Hideo Shigeishi, Taiji Obayashi, Syuichi Munenaga, Nami Obayashi, Yukio Yoshioka, Masaru Konishi, Takako Naruse, et al. Relationship of oral bacterial number with medical hospitalization costs in analysis of Diagnosis Procedure Combination database from single institution in Japan. Scientific reports. 2024. 14. 1. 11114-11114
Kazuhisa Ouhara, Tasuku Takemura, Yuri Taniguchi, Ryousuke Fujimori, Tetsuya Tamura, Yuki Akane, Shinji Matsuda, Yuta Hamamoto, Tomoaki Shintani, Mikihito Kajiya, et al. Leucine-rich alpha-2-glycoprotein 1 affects bone destruction via IL-6 in mouse periodontitis model. Oral diseases. 2024

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MISC (6)：

Development of Cytokine Therapy with BDNF (brain-derived neurotrophic factor) for Periodontal Tissue Regeneration. 2015. 11. 1. 16-28
Kajiya M, Kittaka M, Shiba H, Takewaki M, Takeshita K, Iwata T, Ouhara K, Takeda K, Fujita T, Kurihara H. P-57 Clumps of mesenchymal stem cells/extracellular matrix complex can be a novel tissue engineering therapy for bone regeneration. The journal of the Japanese Society for Dental Materials and Devices. 2014. 33. 5. 462-462
Takeda K, Konishi A, Kajiya M, Matsuda S, Fujita T, Shiba H, Kurihara H. P-5 Brain-derived neurotrophic factor/hyaluronic acid complex enhances periodontal tissue regeneration. The journal of the Japanese Society for Dental Materials and Devices. 2014. 33. 5. 391-391
SHIBA Hideki, TAKEDA Katsuhiro, OUHARA Kazuhisa, KAJIYA Mikihito, FUJITA Tsuyoshi, MIZUNO Noriyoshi, HINO Takamune, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Effects of LL37 on expression of inflammatory cytokines in human pulp cells. 2008. 29. 3. 147-154
TSUDA Hidehiro, SHIBA Hideki, KAJIYA Mikihito, FUJITA Tsuyoshi, TAKEDA Katsuhiro, MIZUNO Noriyoshi, KAWAGUCHI Hiroyuki, KURIHARA Hidemi. Nd:YAG laser irradiation abolishes peptidoglycan-induced increment in IL-6 and IL-8 through p38 signaling pathway in human pulp cells. 2007. 50. 32-32

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Patents (1)：

MAPK inhibition by H2

Lectures and oral presentations (11)：

Symposium: Development of Periodontal Tissue Regenerative Therapy Using Mesenchymal Stem Cells and Bio-3D Printer
(AADOCR Florida-JSPS joint Symposium 2024)
シンポジウム自家間葉系幹細胞とバイオ3Dプリンタを用いた歯周組織再生療法の実用化への展望
(東京都医工連携HUB機構「アカデミア発、医工連携ベンチャーの最前線」 2023)
シンポジウム歯科金属アレルギー診療指針に向かう道標
(日本補綴歯科学会第132回学術大会-設立90周年記念大会- 2023)
Symposium "New Avenues for Regenerative Medicine Opened by 3D Cell Clumps Culture Techniques and Nanodevices"
(The 7th International symposium on biomedical engineering (ISBE2022) 2022)
Focused learning sessions "Clumps of Mesenchymal Stem Cell for Periodontal Tissue Regeneration"
(2021 IADR/AADR/CADR General Session & Exhibition 2021)

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Education (2)：

2005 - 2009 Hiroshima University Graduate School of Biomedical Sciences
1999 - 2005 Hiroshima University Faculty of Dentistry

Work history (7)：

2022/05 - 現在広島大学ナノデバイス研究所教授(併任)
2022/04 - 現在 Department of Innovation & Precision Dentistry, Graduate School of BIomedical and Health Sciences, Hiroshima University Professor
2022/04 - 現在 Center for oral clinical examination, Hiroshima University Hospital Professor
2017/05 - 2022/03 Hiroshima University Graduate School of Biomedical Sciences
2012/05 - 2017/04 広島大学病院口腔維持修復歯科歯周診療科助教

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Awards (7)：

2020/10 - 日本歯周病学会日本歯周病学会学術賞
2015 - 日本歯科保存学会日本歯科保存学会奨励賞
2011 - Hiroshima Conference on Education and Science in Dentistry Best poster award
2009 - 広島大学歯学部同窓会奨励賞
2009 - 日本歯周病学会日本歯周病学会奨励賞

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Association Membership(s) (8)：

JAPANESE SOCIETY OF PERIODONTOLOGY , THE JAPANESE SOCIETY OF CONSERVATIVE DENTISTRY , JAPAN ENDODONTIC ASSOCIATION , 国際歯科研究学会 , 日本歯科基礎医学会 , JAPANESE SOCIETY FOR BONE AND MINERAL RESEARCH , THE JAPANESE SOCIETY FOR REGENERATIVE MEDICINE , 日本口腔検査学会

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