Akihiro Shimba

Affiliation and department：
Job title：助教

Research field (1)： Medical biochemistry

Research keywords (3)：サイトカイン , ホルモン , 免疫学

Research theme for competitive and other funds (10)：

2023 - 2026 Control of immune response and tissue homeostasis by novel IL-15-dependent innate lymphocytes
2023 - 2025 Development of nighttime lighting to promote patient sleep under metameric conditions
2022 - 2025 ストレスがTH17細胞のプロテアーゼの発現上昇と関節炎増悪に寄与する機構の解明
2020 - 2023 IL-15-producing microenvironment supporting innate lymphoid cells and its role in diseases
2020 - 2022 Induction of autoimmune diseases by glucocorticoids

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Papers (21)：

Akihiro Shimba, Shizue Tani-Ichi, Kyoko Masuda, Guangwei Cui, Satoru Munakata, Shinya Abe, Satsuki Kitano, Hitoshi Miyachi, Hiroshi Kawamoto, Koichi Ikuta. A Chimeric IL-7Rα/IL-2Rβ Receptor Promotes the Differentiation of T Cell Progenitors into B Cells and Type 2 Innate Lymphoid Cells. Journal of immunology (Baltimore, Md. : 1950). 2024
Shinya Abe, Takuma Asahi, Takahiro Hara, Guangwei Cui, Akihiro Shimba, Shizue Tani-Ichi, Kohei Yamada, Kazuko Miyazaki, Hitoshi Miyachi, Satsuki Kitano, et al. Hematopoietic cell-derived IL-15 supports NK cell development in scattered and clustered localization within the bone marrow. Cell reports. 2023. 113127-113127
Guangwei Cui, Akihiro Shimba, Jianshi Jin, Nozomi Hojo, Takuma Asahi, Shinya Abe, Aki Ejima, Shinri Okada, Keizo Ohira, Ryoma Kato, et al. CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 36. e2215941120
Daichi Takami, Shinya Abe, Akihiro Shimba, Takuma Asahi, Guangwei Cui, Shizue Tani-Ichi, Takahiro Hara, Keishi Miyata, Masashi Ikutani, Kiyoshi Takatsu, et al. Lung group 2 innate lymphoid cells differentially depend on local IL-7 for their distribution, activation, and maintenance in innate and adaptive immunity-mediated airway inflammation. International immunology. 2023
Takuma Asahi, Shinya Abe, Guangwei Cui, Akihiro Shimba, Tsukasa Nabekura, Hitoshi Miyachi, Satsuki Kitano, Keizo Ohira, Johannes M Dijkstra, Masaki Miyazaki, et al. Liver type 1 innate lymphoid cells lacking IL-7 receptor are a native killer cell subset fostered by parenchymal niches. eLife. 2023. 12

ｍore...

MISC (2)：

Akihiro Shimba, Aki Ejima, Koichi Ikuta. Pleiotropic Effects of Glucocorticoids on the Immune System in Circadian Rhythm and Stress. Frontiers in Immunology. 2021. 12
Akihiro Shimba, Koichi Ikuta. Glucocorticoids Drive Circadian Changes in T-Cell Homing and Response via IL-7 Receptor. JOURNAL OF IMMUNOLOGY. 2017. 198. 1

Books (5)：

グルココルチコイドによる免疫応答の日内変動制御
感染炎症免疫 2019
概日リズムが制御する免疫応答の日内変動と炎症疾患
実験医学 2019
グルココルチコイドによる正負の免疫制御
生体の科学 2019
グルココルチコイドと免疫概日リズムが制御する生体防御機構
医学のあゆみ 2018
グルココルチコイドによる免疫機能の日内変動の制御
アンチ・エイジング医学 2018

Lectures and oral presentations (4)：

Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7R expression
(第46回日本免疫学会総会・学術集会 2017)
Glucocorticoids drive diurnal changes in distribution and response of T cells via IL-7R expression
(24th East Asia Joint Symposium 2017)
グルココルチコイドによる IL-7R および CXCR4 の発現を介した T 細胞維持への影響
(Kyoto T Cell Conference 2015)
Differential roles of IL-7 and IL-2 receptor signals in lymphocyte development and maintenance revealed by IL-7Rα/IL-15Rβ chimera knock-in
(第43回日本免疫学会総会・学術集会 2014)

Education (1)：

2014 - 2017 京都大学医学研究科医科学専攻

Professional career (1)：

博士(医科学) (京都大学)

Work history (2)：

2019/08 - 現在 Kyoto University
2017 - 現在京都大学ウイルス・再生医科学研究所非常勤研究員

Association Membership(s) (1)：

THE JAPANESE SOCIETY FOR IMMUNOLOGY

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