Rchr
J-GLOBAL ID：201801004776104489   Update date: Jun. 17, 2024

Higo Shuichiro

ヒゴ シュウイチロウ | Higo Shuichiro
Affiliation and department：
Osaka University Graduate School of Medicine

About Osaka University Graduate School of Medicine


Job title： Associate Professor (Lecturer)
Homepage URL  (1)： http://www.cardiology.med.osaka-u.ac.jp/?page_id=33635
Research field  (1)： Cardiology
Research keywords  (4)： iPS cell ,  Cardiomyopathy ,  Genome editing ,  Advanced heart failure
Research theme for competitive and other funds  (20)：
  • 2024 - 2027 治療抵抗性心筋不全の層別化・病態解明とゲノム医療の創出
  • 2024 - 2027 デスモゾーム心筋症に対する介入治療法の開発
  • 2023 - 2026 特発性心筋症の診断・ゲノム情報利活用に関する調査研究
  • 2022 - 2025 Generation of disease-specific induced pluripotent stem cell library for molecular-based classification of cardiomyopathies
  • 2022 - 2024 Development of diagnostic biomarkers for arrhythmogenic cardiomyopathy
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Papers (39)：
  • Junjun Li, Ying Hua, Yuting Liu, Xiang Qu, Jingbo Zhang, Masako Ishida, Noriko Yoshida, Akiko Tabata, Hayato Miyoshi, Mikio Shiba, et al. Human induced pluripotent stem cell-derived closed-loop cardiac tissue for drug assessment. iScience. 2024. 27. 2. 108992-108992
  • Moyu Hasegawa, Kenji Miki, Takuji Kawamura, Ikue Takei Sasozaki, Yuki Higashiyama, Masaru Tsuchida, Kunio Kashino, Masaki Taira, Emiko Ito, Maki Takeda, et al. Gene correction and overexpression of TNNI3 improve impaired relaxation in engineered heart tissue model of pediatric restrictive cardiomyopathy. Development, Growth & Differentiation. 2024
  • Shota Okuno, Shuichiro Higo, Takumi Kondo, Mikio Shiba, Satoshi Kameda, Hiroyuki Inoue, Tomoka Tabata, Shou Ogawa, Yu Morishita, Congcong Sun, et al. SARS-CoV-2 spike receptor-binding domain is internalized and promotes protein ISGylation in human induced pluripotent stem cell-derived cardiomyocytes. Scientific Reports. 2023. 13. 1
  • Tatsuya Nishikawa, Mikio Shiba, Yoshihiko Ikeda, Keiko Ohta-Ogo, Takumi Kondo, Tomoka Tabata, Toru Oka, Wataru Shioyama, Hironori Yamamoto, Taku Yasui, et al. Tenascin-C as a Potential Marker for Immunohistopathology of Doxorubicin-Induced Cardiomyopathy. European Heart Journal Open. 2023
  • Hideaki Fujita, Junichi Kaneshiro, Maki Takeda, Kensuke Sasaki, Rikako Yamamoto, Daiki Umetsu, Erina Kuranaga, Shuichiro Higo, Takumi Kondo, Yoshihiro Asano, et al. Estimation of crossbridge-state during cardiomyocyte beating using second harmonic generation. Life Sci Alliance. 2023. 6. 7. e202302070-e202302070
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MISC (12)：
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Books (12)：
  • 非分裂心筋細胞のゲノム編集と難治性心筋症への治療介入
    (株)技術情報協会 ゲノム編集の最新技術と医薬品・遺伝子治療・農業・水畜産物・有用物質生産への活用 2023 ISBN:9784861049781
  • Heart View 疾患iPS細胞を用いた心筋症個別化医療へのアプローチ
    MEDICAL VIEW 2022
  • 医学のあゆみ 難治性心筋症研究におけるゲノム編集
    2021
  • ゲノム編集の難治性心筋症医療応用 実験医学増刊 心不全のサイエンス
    羊土社 2019 ISBN:9784758103770
  • 病因遺伝子 ゲノム編集
    日本臨牀社 2018
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Lectures and oral presentations  (79)：
  • ヘテロ接合性DSG2:p.R119Xが同定された心筋症4症例と短縮型バリアントに対する治療介入検討
    (第137回日本循環器学会近畿地方会 学生・研修医セッション優秀賞 2024)
  • ヘテロ接合性DSG2:p.R119Xバリアントが同定された心筋症4症例
    (第10回日本心筋症研究会 2024)
  • 全身性血栓症を繰り返し複合ヘテロ接合性PROC遺伝子バリアントが同定されたプロテインC欠損症の一例
    (第121回日本内科ことはじめ2024東京 2024)
  • Elucidation of the pathological basis and therapeutic development for advanced heart failure using disease-specific iPS cell-derived cardiomyocytes
    (第97回 日本薬理学会年会 国際心臓研究学会 日本部会(ISHR)共催シンポジウム 「心不全研究の最前線から拓く治療戦略」 2023)
  • Elucidation of the pathological basis and therapeutic development for advanced heart failure using disease-specific iPS cell-derived cardiomyocytes
    (Symposium, Genomic analysis and Genome editing, CVMW2023, The 7th JCS Council Forum on Basic Cardiovascular Research 2023)
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Education (2)：
  • - 2011 Osaka University graduate school of medicine
  • - 1999 Osaka University Faculty of Medicine Medical School
Professional career (1)：
  • M.D., Ph.D. (Osaka University)
Work history (7)：
  • 2024/01 - 現在 Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
  • 2011 - 現在 Osaka University Hospital
  • 2021/01 - 2023/12 Department of Medical Therapeutics for Heart Failure
  • 2018 - 2020 Osaka University Graduate School of Medicine
  • 2004 - 2005 Kobe Ekisaikai Hospital
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Committee career (2)：
  • 2018 - 現在 日本心臓研究学会(ISHR)日本部会 日本心臓研究学会(ISHR)日本部会評議員
  • 2018 - 2019 日本内科学会認定内科医、総合内科専門医問題作成委員
Awards (5)：
  • 2020/12 - 先進医薬研究振興財団 循環医学分野 一般研究助成
  • 2019/06 - 公益財団法人細胞科学研究財団 平成31年度研究助成「心不全-基礎と臨床」
  • 2014/09 - BASIC CARDIOVASCULAR SCIENCES 2014 SCIENTIFIC SESSIONS New Investigator Travel Award
  • 2013/11 - 万有財団 Banyu Foundation Research Grant 生活習慣病領域
  • 2003/11 - American Heart Association AHA 2003 Poster Session Clinical Science Award Winner
Association Membership(s) (4)：
Fellow of the Japanese Society of Internal Medicine (FJSIM) ,  Board Certified Member of The Japanese Circulation Society ,  Board Certified Member of the Japanese Society of Internal Medicine ,  Occupational health physician certified by Japan Medical Association
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