Komatsu Tomohiro

コマツトモヒロ | Komatsu Tomohiro

Affiliation and department：

Research field (4)： Metabolism and endocrinology , Cardiology , Sports science , Pharmacology

Research keywords (4)：脂質代謝 , HDL代謝 , 分子骨格筋学 , 肺高血圧症

Research theme for competitive and other funds (3)：

2024 - 2029 Investigation of the muscle differentiation-promoting effects by high-density lipoprotein (HDL) and mechanisms of the skeletal muscle HDL production system
2020 - 2024 Physiological roles and mechanisms of a novel high density lipoprotein (HDL) production system in skeletal muscle.
2020 - 2023 運動による新規中性脂肪低下メカニズムの解明~骨格筋アポ蛋白C2システムを中心に~

Papers (36)：

Takafumi Nishida, Makoto Ayaori, Junko Arakawa, Yumiko Suenaga, Kazusa Shiotani, Harumi Uto-Kondo, Tomohiro Komatsu, Kazuhiro Nakaya, Yasuhiro Endo, Makoto Sasaki, et al. Liver-specific Lxr inhibition represses reverse cholesterol transport in cholesterol-fed mice. Atherosclerosis. 2024. 117578
Yoshinari Uehara, Tomohiro Komatsu, Kei Sasaki, Satomi Abe, Shihoko Nakashima, Taiki Yamamoto, Ji-Eun Kim, Kyung-Hyun Cho. Cuban policosanol improves high-density lipoprotein cholesterol efflux capacity in healthy Japanese subjects. Frontiers in Nutrition. 2024. 10. 1297008
Kei Sasaki, Hayato Tada, Tomohiro Komatsu, Hisato Terada, Yasuhiro Endo, Katsunori Ikewaki, Yoshinari Uehara. A New Case of Abetalipoproteinemia Caused by Novel Compound Heterozygote Mutations in the MTTP Gene without Fat or Vitamin Malabsorption. Journal of Atherosclerosis and Thrombosis. 2024
Tomohiro Komatsu, Yuka Katsurada, Kazuya Miyashita, Satomi Abe, Takafumi Nishida, Yasuhiro Endo, Manami Teramoto, Kei Sasaki, Junko Arakawa, Makoto Sasaki, et al. Two Cases of Acquired High-Density Lipoprotein Deficiency with Immunoglobulin G4-Related Lecithin-Cholesterol Acyltransferase Autoantibody. Journal of Atherosclerosis and Thrombosis. 2023
Kyung-Hyun Cho, Ji-Eun Kim, Tomohiro Komatsu, Yoshinari Uehara. Protection of Liver Functions and Improvement of Kidney Functions by Twelve Weeks Consumption of Cuban Policosanol (Raydel®) with a Decrease of Glycated Hemoglobin and Blood Pressure from a Randomized, Placebo-Controlled, and Double-Blinded Study with Healthy and Middle-Aged Japanese Participants. Life. 2023. 13. 6. 1319-1319

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MISC (15)：

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Books (5)：

日本臨床第78巻増刊号2 高血圧学(下)
日本臨床社 2020
欧州心臓病学会(ESC)心血管薬物療法ハンドブック日本語翻訳版
OXFORD UNIVERSITY PRESS 2020
疾病の成り立ち(新スタンダード栄養・食物シリーズ4)
東京化学同人 2015 ISBN:9784807916641
脂質異常症診療ガイド Q&A
南山堂 2014 ISBN:9784525234010
成功に導くPCI治療戦略
南江堂 2011 ISBN:9784524263134

Lectures and oral presentations (39)：

High-density lipoprotein mimetics promote mitochondrial function in mouse skeletal muscle.
(6th Asia-Pacific CardioMetabolic Syndrome Congress 2023, Seoul, Korea 2023)
阻害薬非感受性NCX1変異体ノックインマウスを用いた薬効評価系の構築
(血管 2023)
血管平滑筋特異的NCX2遺伝子改変マウスを用いた肺高血圧症モデル実験
(第75回日本薬理学会西南部会 2022)
HDL mimetics promotes mitochondrial function in mouse myoblast cells.
(第95回日本薬理学会年会 2022)
突然死を引き起こす心筋特異的NCX1欠損マウスの心筋細胞Ca2+シグナル異常
(第74回日本薬理学会西南部会 2021)

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Professional career (1)：

博士(医学) (防衛庁防衛医科大学校)

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