Rchr
J-GLOBAL ID:201801004808866041
Update date: May. 16, 2024
Sakabe Tomohiko
サカベ トモヒコ | Sakabe Tomohiko
Affiliation and department:
Job title:
Assistant Professor
Research field (4):
Molecular biology
, Respiratory surgery
, Tumor biology
, Experimental pathology
Research keywords (5):
癌悪性度
, 組織亜型
, 浸潤性肺腺癌
, 肺癌
, 実験病理学
Research theme for competitive and other funds (9):
- 2023 - 2026 肝細胞がんにおける新たな免疫回避メカニズムの解明
- 2022 - 2025 浸潤性肺腺癌における充実型亜型の形成・維持機構の解明と治療薬開発への応用
- 2019 - 2022 Elucidation of molecular mechanism of maspin associated with poor prognosis of patients with lung squamous cell carcinoma
- 2019 - 2022 Regulation of liver cancer stem cells by a lncRNA
- 2019 - 2022 Establishment of for evaluation model of pathological subtypes in lung adenocarcinoma using organoid culture and investigation of formation mechanism
- 2016 - 2019 The elucidation of molecular mechanism of maspin related with unfavorable prognosis of human breast cancer patients
- 2016 - 2019 Investigation of epigenetic changes related to histological subtype in invasive lung adenocarcinoma and development of precision medicine.
- 2014 - 2017 Development of novel therapeutic strategies for targeting liver cancer stem cells based on the multi-omics data.
- 2009 - 2011 肝癌における薬剤感受性増強遺伝子の同定とそれを用いた遺伝子治療法の開発
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Papers (41):
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Taichi Kadonaga, Tomohiko Sakabe, Yoshiteru Kidokoro, Tomohiro Haruki, Kanae Nosaka, Hiroshige Nakamura, Yoshihisa Umekita. Gene expression profiling using targeted RNA-sequencing to elucidate the progression from histologically normal lung tissues to non-invasive lesions in invasive lung adenocarcinoma. Virchows Archiv. 2022. 480. 4. 831-841
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Keiko Hosoya, Kanae Nosaka, Tomohiko Sakabe, Makoto Wakahara, Yuki Oshima, Yoshimasa Suzuki, Hiroshige Nakamura, Yoshihisa Umekita. Clinical Significance of Serglycin Expression in Human Breast Cancer Patients. Anticancer research. 2022. 42. 1. 279-285
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Tomohiko Sakabe, Makoto Wakahara, Goshi Shiota, Yoshihisa Umekita. Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype. Scientific Reports. 2021. 11. 1. 11321-11321
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MAKOTO KAWASAKI, TOMOHIKO SAKABE, ISAMU KODANI, YOSHIHISA UMEKITA. Cytoplasmic-only Expression of Maspin Predicts Poor Prognosis in Patients With Oral Squamous Cell Carcinoma. Anticancer Research. 2021. 41. 9. 4563-4570
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Yuko Tanaka, Takashi Ohno, Taichi Kadonaga, Yoshiteru Kidokoro, Makoto Wakahara, Kanae Nosaka, Tomohiko Sakabe, Yoshimasa Suzuki, Hiroshige Nakamura, Yoshihisa Umekita. Podoplanin expression in cancer-associated fibroblasts predicts unfavorable prognosis in node-negative breast cancer patients with hormone receptor-positive/HER2 - negative subtype. Breast Cancer. 2021. 28. 4. 822-828
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MISC (10):
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大野 貴志, 荒木 邦夫, 目次 裕之, 坂部 友彦, 野坂 加苗, 中村 廣繁, 梅北 善久. 病理病期IA期肺腺癌におけるMaspin発現の意義. 日本外科学会定期学術集会抄録集. 2019. 119回. PS-045
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坂部 友彦, 野坂 加苗, 梅北 善久. 細胞質局在maspinは、EMT関連遺伝子の発現を増加させ、乳癌における細胞浸潤を亢進させる(Cytoplasmic maspin increases EMT-associated gene expression and promotes breast cancer cell invasion). 日本癌学会総会記事. 2018. 77回. 2069-2069
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坂部 友彦, 野坂 加苗, 梅北 善久. 乳癌細胞株におけるmaspin細胞内局在および機能解析. 日本病理学会会誌. 2018. 107. 1. 425-426
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大野 貴志, 窪内 康晃, 坂部 友彦, 野坂 加苗, 中村 廣繁, 梅北 善久. 病理病期IA期肺腺癌におけるMaspinの局在と予後との関連. 日本病理学会会誌. 2018. 107. 1. 473-473
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板場則子, 神吉けい太, 坂部友彦, 坂部友彦, 阿部健一郎, 安積遵哉, 國田慎也, 清水寛基, 河野洋平, 森本稔, et al. 肝細胞分化誘導性の新規低分子化合物の解析. 肝臓. 2015. 56. Supplement 1
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Patents (3):
Education (3):
- 2009 - 2013 Tottori University Graduate School of Medical Sciences Major in Regenerative Medicine and Biofunction
- 2007 - 2009 Tottori University Graduate School of Medical Sciences Major in Regenerative Medicine and Biofunction
- 2003 - 2007 Tottori University Faculty of Medicine School of Life Sciences
Work history (4):
- 2023/03 - 現在 Tottori University
- 2013/04 - 2023/02 Tottori University
- 2012/04 - 2013/03 Tottori University Graduate School of Medical Sciences
- 2009/04 - 2012/03 Japan Society for the Promotion of Science
Awards (2):
- 2013/04 - 米子医学会賞 Identification of the genes chemosensitizing hepatocellular carcinoma cells to interferon-α/5-fluorouracil and their clinical significance
- 2012/11 - 日本消化器癌発生学会 研究奨励賞 肝癌幹細胞における細胞内シグナルネットワーク解析
Association Membership(s) (2):
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