Rchr
J-GLOBAL ID：201801004838808402   Update date: Oct. 09, 2024

Ishii Hirotaka

イシイ ヒロタカ | Ishii Hirotaka
Affiliation and department：
Nippon Medical School Department of Anatomy and Neurobiology

About Nippon Medical School Department of Anatomy and Neurobiology


Job title： Graduate School Professor
Other affiliations (1)：
  • Nippon Medical School
Homepage URL  (1)： http://www.nms-anatomy2.com/
Research field  (1)： Anatomy
Research keywords  (5)： 形態機能学 ,  Chemotherapy resistance ,  Neuroendocrinology ,  Reproductive endocrinology ,  Estrogen
Research theme for competitive and other funds  (24)：
  • 2023 - 2026 ESR1遺伝子のゲノム構造再編成によるエストロゲン感受性腫瘍増悪機構の解明
  • 2018 - 2022 Mechanisms of endocrine- and chemotherapy-resistance acquisition in estrogen-sensitive tumors by ESR1 isoforms
  • 2018 - 2021 Molecular and morphofunctional study on the novel regulation system for reproduction based on the input of various enviromental information
  • 2014 - 2017 Morphofunctional study on inputs of the environmental information, three dimensional interacition and life cycle, of a new system for reproductive regulation.
  • 2013 - 2016 Regulatory mechanisms of estrogen receptor gene expression by alternative promoter usage and alternative splicing
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Papers (65)：
  • Mai Otsuka, Kinuyo Iwata, Yuki Otsuka, Yoshihisa Uenoyama, Hitoshi Ozawa, Hirotaka Ishii. Absence of sex differences in diabetes-induced suppression of KNDy neurons in rats. The Journal of endocrinology. 2024
  • Masahiro Morishita, Ikuto Aiba, Dai Kaneko, Mika Soma, Hirotaka Ishii. Sex Steroid Receptor Expression in Sexually Dimorphic Nuclei in the Mouse Brain. Nihon Ika Daigaku Igakkai Zasshi. 2024. 20. 2. 124-125
  • Yujiro Hattori, Shigeyuki Tahara, Hitoshi Ozawa, Akio Morita, Hirotaka Ishii. Transcriptomic Profiling of Lactotroph Pituitary Neuroendocrine Tumors via RNA Sequencing and Ingenuity Pathway Analysis. Neuroendocrinology. 2024
  • Haruko Watanabe-Takano, Katsuhiro Kato, Eri Oguri-Nakamura, Tomohiro Ishii, Koji Kobayashi, Takahisa Murata, Koichiro Tsujikawa, Takaki Miyata, Yoshiaki Kubota, Yasuyuki Hanada, et al. Endothelial cells regulate alveolar morphogenesis by constructing basement membranes acting as a scaffold for myofibroblasts. Nature communications. 2024. 15. 1. 1622-1622
  • Yuyu Kunimura, Kinuyo Iwata, Hirotaka Ishii, Hitoshi Ozawa. Chronic estradiol exposure suppresses luteinizing hormone surge without affecting kisspeptin neurons and estrogen receptor alpha in anteroventral periventricular nucleus. Biology of reproduction. 2024. 110. 1. 90-101
ｍore...
MISC (112)：
  • 服部 裕次郎, 小澤 実那, 肥後 心平, 森下 雅大, 大塚 真衣, 松本 恵介, 小澤 一史, 石井 寛高. 抗ヒトERβ特異的モノクローナル抗体(PPZ0506)を用いたラット及びマウスERβタンパク質に対する免疫組織化学染色法の確立. 日本内分泌学会雑誌. 2023. 98. 5. 1398-1398
  • 森下雅大, 肥後心平, 岩田衣世, 石井寛高. げっ歯類の脳におけるエストロゲン受容体β発現の免疫組織学的解析. 日本組織細胞化学会総会・学術集会講演プログラム・予稿集. 2023. 64th (CD-ROM)
  • 森下雅大, 肥後心平, 岩田衣世, 石井寛高. マウスとラットの脳におけるエストロゲン受容体βの分布とその性差. 日本医科大学医学会雑誌. 2023. 19. 4
  • 美辺詩織, 岩田衣世, 渡辺雄貴, 渡辺雄貴, 石井寛高, 小澤一史. 発達期の栄養環境が生殖神経内分泌機構に及ぼす影響. 日本神経内分泌学会学術集会プログラム・抄録集. 2023. 49th
  • 石井寛高, 森下雅大, 肥後心平. 免疫組織化学法の原理と基礎. 組織細胞化学. 2023. 2023
ｍore...
Books (3)：
  • CLINICAL NEUROSCIENCE
    CHUGAI-IGAKUSHA 2023
  • Histochemistry and Cytochemistry 2023
    Japan Society of Histochemistry and Cytochemistry 2023
  • Neuroactive Steroids in Brain Function, Behavior and Neuropsychiatric Disorders
    Springer Dordrecht 2008
Lectures and oral presentations  (72)：
  • 変形性膝関節症滑膜での最適参照遺伝子の選定に基づいたステロイドホルモン受容体の発現解析と そのBMI,性との相関について
    (日本解剖学会総会・全国学術集会(第122回) 2017)
  • C末端欠損型性ステロイド受容体変異体の恒常的転写活性化能獲得機構の解明.
    (日本解剖学会総会・全国学術集会(第122回) 2017)
  • 日本医科大学における実習手順:全体のデザイン,モチベーション,評価
    (日本解剖学会総会・全国学術集会(第122回) 2017)
  • C末端欠損型性ステロイド受容体変異体の恒常的転写活性化能獲得機構の解明
    (日本解剖学会総会・全国学術集会(第122回) 2017)
  • 変形性膝関節症滑膜での最適参照遺伝子の選定に基づいたステロイド受容体の発現解析とそのBMI,性との相関について
    (日本解剖学会総会・全国学術集会(第122回) 2017)
ｍore...
Education (4)：
  • 2003 - 2006 The University of Tokyo Graduate School of Science Physics
  • 2001 - 2003 The University of Tokyo Graduate School of Science Physics
  • 1999 - 2001 The University of Tokyo Department of Science Physics
  • 1997 - 1999 The University of Tokyo Department of Art and Sciences Science Cource I
Professional career (1)：
  • Ph.D. (The University of Tokyo)
Work history (6)：
  • 2022/04 - 現在 Nippon Medical School Graduate School of Medicine Department of Anatomy and Neurobiology Graduate School Professor
  • 2018/04 - 2022/03 Nippon Medical School Graduate School of Medicine Department of Anatomy and Neurobiology Associate Professor
  • 2013/04 - 2018/03 Nippon Medical School, Graduate School of Medicine Department of Anatomy and Neurobiology Senior Assistant Professor
  • 2012/04 - 2013/03 Nippon Medical School, Graduate School of Medicine Department of Anatomy and Neurobiology Assistant Professor
  • 2010/04 - 2012/03 Nippon Medical School, Graduate School of Medicine Department of Physiology Assistant Professor
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Committee career (4)：
  • 2023/01 - 現在 日本組織細胞化学会 評議員
  • 2022/08 - 現在 日本解剖学会 代議員
  • 2012/04 - 現在 日本神経内分泌学会 評議員
  • 2012/03 - 現在 日本生理学会 評議員
Awards (5)：
  • 2023/10 - Japan Society of Histochemistry and Cytochemistry 25th Award for Excellent Papers in Acta Histochemica et Cytochemica Optimized Mouse-on-mouse Immunohistochemical Detection of Mouse ESR2 Proteins with PPZ0506 Monoclonal Antibody
  • 2021/10 - Japan Neuroendocrine Society Kawakami Award
  • 2014/11 - 日本内分泌学会 第24回臨床内分泌代謝Update 優秀ポスター賞 新規ヒトエストロゲン受容体変異体の同定と機能解析
  • 2011/03 - 日本生理学会 Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences Voltage-gated Ca<sup>2+</sup> channels mRNAs and T-type Ca<sup>2+</sup> currents in rat gonadotropin-releasing hormone neurons
  • 2010/03 - 日本生理学会 Hiroshi and Aya Irisawa Memorial Award for Excellent Papers in The Journal of Physiological Sciences Gene structures, biochemical characterization and distribution of rat melatonin receptors.
Association Membership(s) (7)：
THE JAPAN NEUROSCIENCE SOCIETY ,  THE BIOPHYSICAL SOCIETY OF JAPAN ,  THE JAPANESE BIOCHEMICAL SOCIETY ,  Japan Neuroendocrine Society ,  THE PHYSIOLOGICAL SOCIETY OF JAPAN ,  JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY ,  THE JAPANESE ASSOCIATION OF ANATOMISTS
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