- 2022 - 2025 Studies on mechanism and therapeutic approach of atherosclerosis using genetically-modified mice and fresh cadavers
- 2020 - 2022 Protein semi-synthesis-based construction of protein library with diversity in post-translational modification
- 2017 - 2020 Rational design of high functional biosupra and development of therapeutic evaluation system with disease models
- 2016 - 2020 Development of methods for modification of proteins with its application to protein drugs
- 2016 - 2019 Use of modified U1 snRNA for rescue from exon skipping caused by 5' splice site mutation of human CTSA gene
- 2016 - 2018 In cellulo crystallography with a synchrotron for a human neuraminidase
- 2014 - 2017 Development of neoglycobiologics and application for drug discovery for lysosomal diseases
- 2013 - 2017 Identification of molecular bases and development of diagnostic, preventive, and therapeutic methods in novel genetic diseases of animals
- 2014 - 2016 Establishment of induced neurons (iN cells) derived from lysosomal disease patients involving neurological symptoms and elucidation of regulatory mechanism of neurodegeneration
- 2013 - 2016 Mechanism of neuronal cell death in GM2 gangliosidosis
- 2013 - 2015 神経変性を伴うリソソーム蓄積症におけるシナプス病態の解明と治療への応用
- 2012 - 2014 Discovery of novel compounds regulating traffic to lysosomes and application for development of therapeutics
- 2011 - 2014 Development of neo-biologics targeted on protein-protein interaction sites
- 2011 - 2014 Development and application of efficient identification method for drugable proteins based on natural products and bioorganic chemistries
- 2011 - 2012 Development of a novel approach toward nucleic acids-based therapeutics
- 2006 - 2008 Structure-based modification of lysosomal enzymes: development of new enzyme replacement therapy for lysosomal diseases
- 2006 - 2007 血液脳関門透過能をもつES細胞由来細胞株の樹立と脳内ターゲッティング機構
- 2002 - 2003 ヒト血管内皮細胞由来の幹細胞誘引因子の作用機構と組織ターゲッティングへの応用
- 2002 - 2003 Synthesis and Functional Analysis of Cell Adhesion Inhibitory Polyketides
- 2000 - 2002 Development and application of tissue-directed medicinal resources based on biotechnology
- 1997 - 1998 Deficiency of Endothelin-Degrading Enzyme and Abnormality in Central Nervous System
- 1996 - 1998 Structural analysis and molecular designing of enzyme proteins : Its application to clarification of pathology of inherited metabolic diseases and development of therapy
- 1997 - 1997 リソソーム酵素のプロセシング及び分解制御機構とその遺伝病の分子機構の解明
- 1996 - 1996 リソソーム酵素のプロセシング及び分解制御機構とその遺伝病の分子病態の解明
- 1995 - 1995 多機能性蛋白による糖鎖分解酵素の制御機構とその欠損症の分子病理
- 1994 - 1995 Three-dimensional imaging of cells and tissues for the clarification of pathogenesis of inherited metabolic diseases.
- 1994 - 1995 Etiology and Pathogenesis of CDG Syndrome
- 1994 - 1994 中枢神経系における多機能性糖蛋白質とそのペプチド性基質の局在性に関する研究
- 1994 - 1994 多機能性蛋白による糖鎖分解酵素の制御機構とその欠損症の分子病理
- 1993 - 1993 多機能性蛋白による糖鎖分解酵素の制御機構とその欠損症の分子病理
- 1993 - 1993 遺伝性ライソゾーム病における変異遺伝子発現機序の解析
- 1991 - 1993 Gene expression and its application to the investigation on pathogenesis of congenital metabolic diseases and development of therapy for them.
- 1992 - 1992 遺伝性ライソゾーム病における変異遺伝子発現機序の解析
- 1991 - 1991 遺伝性ライソゾ-ム病における変異遺伝子発現機序の解析
- 1989 - 1991 Melecular genetic study in the pathogenesis of achondroplasia
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