Rchr
J-GLOBAL ID：201801004947497654
Update date: Feb. 01, 2024
Doura Tomohiro
ドウウラ トモヒロ | Doura Tomohiro
Affiliation and department：
Research field (3)：
Bioorganic chemistry
, Pharmaceuticals - chemistry and drug development
, Biochemistry
Research keywords (3)：
chemogenetics
, chemical biology
, medicinal chemistry
Research theme for competitive and other funds (4)：
- 2022 - 2025 Development of in vivo chemogenetics which allows cell specific regulation of GPCRs
- 2019 - 2022 Development of sunitinib-based molecular targeted drug conjugates
- 2016 - 2019 がん選択的化学療法の実現を目指した細胞内滞留型プロドラッグの開発
- 2015 - 2016 beta-ガラクトシダーゼ活性により機能発現するヘキストを基盤とするアルキル化剤の開発
Papers (19)：
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Kento Ojima, Wataru Kakegawa, Tokiwa Yamasaki, Yuta Miura, Masayuki Itoh, Yukiko Michibata, Ryou Kubota, Tomohiro Doura, Eriko Miura, Hiroshi Nonaka, et al. Coordination chemogenetics for activation of GPCR-type glutamate receptors in brain tissue. Nature communications. 2022. 13. 1. 3167-3167
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Yuta Miura, Akinobu Senoo, Tomohiro Doura, Shigeki Kiyonaka. Chemogenetics of cell surface receptors: beyond genetic and pharmacological approaches. RSC Chemical Biology. 2022. 3. 269-287
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Akinobu Senoo, Yutaro Yamada, Kento Ojima, Tomohiro Doura, Itaru Hamachi, Shigeki Kiyonaka. Orthogonal Activation of Metabotropic Glutamate Receptor Using Coordination Chemogenetics. Frontiers in Chemistry. 2022. 9. 825669
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Yu-Hsuan Tsai, Tomohiro Doura, Shigeki Kiyonaka. Tethering-based chemogenetic approaches for the modulation of protein function in live cells. Chemical Society Reviews. 2021. 50. 14. 7909-7923
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Kento Ojima, Kazuki Shiraiwa, Kyohei Soga, Tomohiro Doura, Mikiko Takato, Kazuhiro Komatsu, Michisuke Yuzaki, Itaru Hamachi, Shigeki Kiyonaka. Ligand-directed two-step labeling to quantify neuronal glutamate receptor trafficking. Nature Communications. 2021. 12. 1. 831
ｍore...
MISC (1)：
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Qi An, Tomohiro Doura, Fuminori Sugihara, Shinsuke Sando. Design of chemical shift switching F-19 MRI probe for imaging of reactive oxygen species. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2012. 244
Books (1)：
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実験医学2016年12月号 Vol.34 No.19 pp.3197-3201、クローズアップ実験法:生体組織中のlacZ発現細胞のライブ蛍光検出
羊土社 2016 ISBN:9784758101585
Education (3)：
- 2009 - 2012 Kyushu University
- 2007 - 2009 Osaka University
- 2003 - 2007 Osaka Prefecture University
Professional career (1)：
Work history (7)：
Association Membership(s) (3)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE CHEMICAL SOCIETY OF JAPAN
