Tomoshige Shusuke

トモシゲシュウスケ | Tomoshige Shusuke

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Pharmaceuticals - chemistry and drug development , Chemical biology

Research keywords (5)： Neurodegenerative Disorders , PROTAC , Ubipuitin Ligase , Post-translational modification , Targeted Protein Degradation

Research theme for competitive and other funds (8)：

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Papers (37)：

Shinichi SatoShogo MiyanoKeita, NakaneZhengyi LiuMunehiro, KumashiroTomohide SaioYuya TanakaAkira, ShigenagaChizu FujimuraEri KoyanagiHafumi NishiShusuke TomoshigeMinoru Ishikawa. Tyrosine Bioconjugation Using Stably Preparable Urazole Radicals. Tetrahedron Chem. 2024. 100111
Keita Nakane, Chizu Fujimura, Shogo Miyano, Zhengyi Liu, Tatsuya Niwa, Hafumi Nishi, Tetsuya Kadonosono, Hideki Taguchi, Shusuke Tomoshige, Minoru Ishikawa, et al. Laccase-catalyzed tyrosine click reaction with 1-methyl-4-arylurazole: rapid labeling on protein surfaces. Chemical Communications. 2024
Wakana Yamada, Shusuke Tomoshige, Sho Nakamura, Shinichi Sato, Minoru Ishikawa. Targeted protein degradation in the mitochondrial matrix and its application to chemical control of mitochondrial morphology. Chemical Science. 2024. 15. 14625-14634
Misaki Kabasawa, Masateru Furuta, Yuuka Ibayashi, Kaori Kanemaru, Haruki Kohatsu, Fumiyo Kuramochi, Kenji Yamatoya, Kazuya Nakata, Yoshikazu Nakamura, Shusuke Tomoshige, et al. Plakevulin A induces apoptosis and suppresses IL-6-induced STAT3 activation in HL60 cells. Bioorganic & Medicinal Chemistry Letters. 2024. 129886
Shusuke Tomoshige, Fumiko Komatsu, Tomoko Kikuchi, Miku Sugiyama, Yushi Kawasaki, Kenji Ohgane, Yuuki Furuyama, Shinichi Sato, Minoru Ishikawa, Kouji Kuramochi. A small-molecule degron with a phenylpropionic acid scaffold. Bioorganic & Medicinal Chemistry. 2024. 117789

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MISC (13)：

石川稔, 伊藤拓水, 伊藤幸裕, 友重秀介. 標的タンパク質分解薬. 現代化学. 2024. 643. 51-57
山田若菜, 佐藤伸一, 石川稔, 友重秀介. ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発. MEDCHEM NEWS. 2024. 34. 145-149
友重秀介, 石川稔. 標的タンパク質分解誘導化合物PROTACの開発. 月刊PHARM STAGE. 2024. 24. 2. 49-53
Wakana Yamada, Shusuke Tomoshige, Sho Nakamura, Shinichi Sato, Minoru Ishikawa. Targeted Protein Degradation in the Mitochondrial Matrix and Its Application to Chemical Control of Mitochondrial Morphology. ChemRxiv. 2024
石川稔, 友重秀介. 標的タンパク質分解薬PROTAC. PEPTIDE NEWS LETTER JAPAN. 2023. 128. 7-10

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Books (1)：

Lectures and oral presentations (96)：

シャペロンを利用する標的タンパク質分解法の開発
(第39回有機合成化学若手研究者の仙台セミナー 2024)
ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発
(第41回メディシナルケミストリーシンポジウム 2024)
ミトコンドリア局在タンパク質分解誘導薬のリンカー構造活性相関
(第41回メディシナルケミストリーシンポジウム 2024)
Targeted Protein Degradation in the Mitochondrial Matrix and its Application to Chemical Control of Mitochondrial Morphology
(International Chemical Biology Society Annual Meeting 2024 2024)
チロシン残基人工糖修飾によるアミロイドβの凝集性変化
(第18回バイオ関連化学シンポジウム 2024)

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Education (2)：

2011 - 2016 The University of Tokyo Graduate School of Pharmaceutical Sciences
2006 - 2011 Chiba University Faculty of Engineering Department of Applied Chemistry and Biotechnology

Professional career (1)：

Work history (4)：

2019/09 - 現在 Tohoku University Graduate School of Life Sciences Assistant Professor
2022/02 - 2025/01 Tohoku University
2018/04 - 2019/08 Tokyo University of Science Department of Applied BioScience, Faculty of Science and Technology Assistant Professor
2016/04 - 2018/03 University of Notre Dame Department of Chemistry and Biochemistry Postdoctoral Researcher

Committee career (1)：

Awards (6)：

2023/11 - 日本薬学会医薬化学部会 MCS優秀賞ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発
2022/12 - 有機合成化学協会大正製薬研究企画賞
2021/12 - 東北大学大学院生命科学研究科研究奨励賞
2021/03 - Japan Society of Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum
2017/10 - Division of Medicinal Chemistry, Pharmaceutical Society of Japan Award for Excellent Presentation

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Association Membership(s) (4)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本化学会生体機能関連化学部会

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