Tomoshige Shusuke

トモシゲシュウスケ | Tomoshige Shusuke

Affiliation and department：
Job title： Assistant Professor

Research field (2)： Pharmaceuticals - chemistry and drug development , Chemical biology

Research keywords (5)： Neurodegenerative Disorders , PROTAC , Ubipuitin Ligase , Post-translational modification , Targeted Protein Degradation

Research theme for competitive and other funds (8)：

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Papers (32)：

Yugo Mishima, Shusuke Tomoshige, Shinichi Sato, Minoru Ishikawa. Allosteric Hsp70 Modulator YM-1 Induces Degradation of BRD4. Chemical and Pharmaceutical Bulletin. 2024. 72. 2. 161-165
Choon Kim, Shusuke Tomoshige, Mijoon Lee, Helen I. Zgurskaya, Shahriar Mobashery. Penetration through Outer Membrane and Efflux Potential in Pseudomonas aeruginosa of Bulgecin A as an Adjuvant to β-Lactam Antibiotics. Antibiotics. 2023. 12. 2. 358
Keita Nakane, Haruto Nagasawa, Chizu Fujimura, Eri Koyanagi, Shusuke Tomoshige, Minoru Ishikawa, Shinichi Sato. Switching of Photocatalytic Tyrosine/Histidine Labeling and Application to Photocatalytic Proximity Labeling. International Journal of Molecular Sciences. 2022. 23. 19. 11622-11622
Keita Nakane, Tatsuya Niwa, Michihiko Tsushima, Shusuke Tomoshige, Hideki Taguchi, Hiroyuki Nakamura, Minoru Ishikawa, Shinichi Sato. BODIPY Catalyzes Proximity-Dependent Histidine Labelling. ChemCatChem. 2022. 14. 9. e202200077
Keigo Hirai, Hiroko Yamashita, Shusuke Tomoshige, Yugo Mishima, Tatsuya Niwa, Kenji Ohgane, Mayumi Ishii, Kayoko Kanamitsu, Yui Ikemi, Shinsaku Nakagawa, et al. Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties. ACS Medicinal Chemistry Letters. 2022. 13. 3. 396-402

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MISC (11)：

友重秀介, 石川稔. 標的タンパク質分解誘導化合物PROTACの開発. 月刊PHARM STAGE. 2024. 24. 2. 49-53
Wakana Yamada, Shusuke Tomoshige, Sho Nakamura, Shinichi Sato, Minoru Ishikawa. Targeted Protein Degradation in the Mitochondrial Matrix and Its Application to Chemical Control of Mitochondrial Morphology. ChemRxiv. 2024
石川稔, 友重秀介. 標的タンパク質分解薬PROTAC. PEPTIDE NEWS LETTER JAPAN. 2023. 128. 7-10
Keita Nakane, Yuki Hoshino, Kosuke Dodo, Shusuke Tomoshige, Minoru Ishikawa, Taniyuki Furuyama, Shinichi Sato. Near-Infrared-Light-Activatable Proximity Labeling of Bead-Binding Proteins. ChemRxiv. 2023
友重秀介, 石川稔. 標的タンパク質分解薬による創薬パラダイムシフト -低分子リガンドの活躍. 月刊細胞. 2022. 54. 9. 504-507

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Lectures and oral presentations (86)：

Hsp70モジュレーターによるBRD4の分解誘導
(第35回万有仙台シンポジウム 2024)
ミトコンドリアプロテアーゼClpPを利用したタンパク質分解薬の構造活性相関研究
(第35回万有仙台シンポジウム前日ミニシンポジウム 2024)
ユビキチンリガーゼ CHIP を用いたタンパク質分解キメラ化合物の創製
(日本薬学会第144年会 2024)
標的タンパク質分解誘導化合物PROTAC および周辺技術による新規創薬モダリティ ~基礎から最新の知見、そして産業における動向~
(2024)
ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発
(第40回メディシナルケミストリーシンポジウム 2023)

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Education (2)：

2011 - 2016 The University of Tokyo Graduate School of Pharmaceutical Sciences
2006 - 2011 Chiba University Faculty of Engineering Department of Applied Chemistry and Biotechnology

Professional career (1)：

Work history (4)：

2019/09 - 現在 Tohoku University Graduate School of Life Sciences Assistant Professor
2022/02 - 2025/01 Tohoku University
2018/04 - 2019/08 Tokyo University of Science Department of Applied BioScience, Faculty of Science and Technology Assistant Professor
2016/04 - 2018/03 University of Notre Dame Department of Chemistry and Biochemistry Postdoctoral Researcher

Committee career (1)：

Awards (6)：

2023/11 - 日本薬学会医薬化学部会 MCS優秀賞ミトコンドリア内タンパク質を標的とするタンパク質分解誘導薬の開発
2022/12 - 有機合成化学協会大正製薬研究企画賞
2021/12 - 東北大学大学院生命科学研究科研究奨励賞
2021/03 - Japan Society of Bioscience, Biotechnology, and Agrochemistry The Excellent Paper Award Published in Bioscience, Biotechnology, & Biochemistry Isolation, synthesis, and biological activities of a bibenzyl from Empetrum nigrum var. japonicum
2017/10 - Division of Medicinal Chemistry, Pharmaceutical Society of Japan Award for Excellent Presentation

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Association Membership(s) (4)：

THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , THE PHARMACEUTICAL SOCIETY OF JAPAN , 日本化学会生体機能関連化学部会

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