Rchr
J-GLOBAL ID:201801005084778729   Update date: Mar. 15, 2024

Tsumuraya Takeshi

ツムラヤ タケシ | Tsumuraya Takeshi
Affiliation and department:
Research field  (3): Chemical biology ,  Molecular biochemistry ,  Biochemistry
Research keywords  (6): biofunctional moletule ,  directed evolution ,  transition-state analog ,  hybridoma ,  monoclonal antibody ,  library
Research theme for competitive and other funds  (22):
  • 2022 - 2025 Development of Caribbean ciguatoxin-specific antibodies for prevention and treatment of ciguatera
  • 2019 - 2022 Development of a trace detection method based on monoclonal antibodies recognizing Carribbean ciguatoxin.
  • 2016 - 2019 A molecular design of molecular-targeting peptides (mid-size medicines) with cell membrane permeability.
  • 2014 - 2017 ホロ酵素型抗体酵素法によるテーラーメイド人工酵素(抗体酵素)の新機能開拓
  • 2013 - 2016 A novel methodology for generation of molecular-targeting drugs via directed evolution in combinatorial libraries of conformationally constrained peptides
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Papers (85):
  • Toshiaki Yokozeki, Madoka Kawabata, Kazuhiro Fujita, Masahiro Hirama, Takeshi Tsumuraya. Sensitive Detection of Ciguatoxins Using a Neuroblastoma Cell-Based Assay with Voltage-Gated Potassium Channel Inhibitors. Toxins. 2024. 16. 3. 118-118
  • Toshiaki Yokozeki, Yuka Hama, Kazuhiro Fujita, Tomoji Igarashi, Masahiro Hirama, Takeshi Tsumuraya. Evaluation of relative potency of calibrated ciguatoxin congeners by near-infrared fluorescent receptor binding and neuroblastoma cell-based assays. Toxicon. 2023. 230. 107161-107161
  • Greta Gaiani, Francesca Cucchi, Anna Toldrà, Karl B Andree, María Rey, Takeshi Tsumuraya, Ciara K O'Sullivan, Jorge Diogène, Mònica Campàs. Electrochemical biosensor for the dual detection of Gambierdiscus australes and Gambierdiscus excentricus in field samples. First report of G. excentricus in the Balearic Islands. The Science of the total environment. 2021. 150915-150915
  • Daisuke Fujiwara, Kousuke Mihara, Ryo Takayama, Yusuke Nakamura, Mitsuhiro Ueda, Takeshi Tsumuraya, Ikuo Fujii. Chemical Modification of Phage-Displayed Helix-Loop-Helix Peptides to Construct Kinase-Focused Libraries. Chembiochem : a European journal of chemical biology. 2021
  • G. Gaiani, S. Leonardo, Tudó, A. Toldrà, M. Rey, K. B. Andree, T. Tsumuraya, M. Hirama, J. Diogène, C. K. O'Sullivan, et al. Rapid detection of ciguatoxins in Gambierdiscus and Fukuyoa with immunosensing tools. Ecotoxicology and Environmental Safety. 2020. 204
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MISC (17):
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Patents (11):
  • シガトキシン類CTX1Bおよび54-デオキシ-CTX1B を認識するモノクローナル抗体およびそれを用いるシガトキシン類検出キット
  • 1. 抗体断片のスクリーニング方法及びアッセイシステム
  • シガトキシン類を認識するヒト化抗体
  • 1. ヒトインターロイキン-5受容体(hIL-5R)結合ペプチド
  • CTX3CのA-E環部をもつハプテン部を有するタンパク質コンジュゲートで免疫して得られるシガトキシンCTX3C抗体およびその作製方法
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Books (7):
  • バイオサイエンス実験:入門から応用へ
    大阪公立大学共同出版会 2016
  • 新機能抗体開発ハンドブック
    NTS 2012
  • 化学フロンティア22:生命現象を理解する分子ツール
    化学同人 2010
  • 産学官連携の研究開発
    中央経済社 2009
  • ナノバイオ大辞典
    テクノシステム 2007
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Lectures and oral presentations  (25):
  • Sandwich ELISA detection of ciguatoxins using anti-ciguatoxin monoclonal antibodies
    (Workshop on Emerging Marine Toxins 2016)
  • 有機合成化学との連携による抗体タンパク質の機能化
    (近畿化学協会ヘテロ原子部会平成28年度第1回談話会 2016)
  • Sandwich ELISA detection of ciguatoxins using anti-ciguatoxin monoclonal antibodies
    (The International Chemical Congress of Pacific Basin Societies (PACIFICHEM 2015) 2015)
  • Procuction of anti-ciguatoxin monoclonal antibodies using synthetic haptens: sandwich ELISA detection of ciguatoxins
    (Rapid Test Workshop “Rapid Testing for Seafood Contaminants” 2014)
  • Catalytic antibodies with luciferase activity
    (Enzyme Engineering XXII 2013)
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Education (2):
  • 1985 - 1990 University of Tsukuba
  • 1981 - 1985 University of Tsukuba
Work history (11):
  • 2022/04 - 現在 Osaka Metropolitan University Department of Biological Chemistry, Graduate School of Science Professor
  • 2017/04 - 現在 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2007/04 - 2017/03 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2005/04 - 2007/03 Osaka Prefecture University Graduate School of Science, Department of Biological Science
  • 2003/10 - 2005/03 Osaka Prefecture University
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Committee career (13):
  • 2009/02 - 現在 有機合成化学協会 関西支部 幹事
  • 2009/01 - 現在 酵素工学研究会 幹事
  • 2008/03 - 現在 日本化学会 フロンティア生命化学研究会 理事
  • 2008/03 - 現在 コンビナトリアル・バイオエンジニアリング研究会 幹事
  • 2006/01 - 現在 AOAC (The Association of Analytical Communities) International Marine and Freshwater Toxins Task Force Member
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Awards (2):
  • 2002/09 - 日本化学会 第17 回若い世代の特別講演賞
  • 1995/01 - 日本化学会 第68日本化学会秋季年会講演賞
Association Membership(s) (14):
THE CRYSTALLOGRAPHIC SOCIETY OF JAPAN ,  コンビナトリアル・バイオエンジニアリング研究会 ,  Japanese Society of Enzyme Engineering ,  Protein Society ,  PROTEIN SCIENCE SOCIETY OF JAPAN ,  AOAC (The Association of Analytical Communities) International ,  KINKI CHEMICAL SOCIETY, JAPAN ,  The Japanese Peptide Society ,  The Society for Biotechnology, Japan ,  日本化学会 フロンティア生命化学研究会 ,  THE PHARMACEUTICAL SOCIETY OF JAPAN ,  American Chemical Society ,  THE SOCIETY OF SYNTHETIC ORGANIC CHEMISTRY, JAPAN ,  THE CHEMICAL SOCIETY OF JAPAN
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