Research theme for competitive and other funds (12)：
2022 - 2025 Elucidation of pathophysiology of uncontrolled bleeding due to disruption of spatiotemporal regulation of fibrinolysis using real-time imaging analysis.
2022 - 2025 Real-time imaging analysis of hemostatic thrombus stabilization and its failure
2020 - 2023 Analysis of coagulation and fibrinolytic functions and vascular endothelium-platelet interaction using disease-specific iPS cells
2019 - 2022 Understanding in spatio-temporal regulation mechanism of thrombus formation and dissolution for realization of appropriate antithrombotic therapy
2017 - 2020 Vasa Vasorum in Abdominal Aortic Aneurysm
2016 - 2019 Various reguratory mechanisms of activated-platelet' memberane-based activation of fibrinolysis.
2015 - 2018 The intrinsic roles of human PAI-1 in adipocyte differentiation and function with using patient-derived iPS cells.
2013 - 2016 Elucidation of intrinsic fibrinolytic activities potentiated vascular endothelial cells and its possibility in prophylaxis of thrombotic disease
2012 - 2015 Role of phosphatidylserine on activated platelets on tissue factor initiated blood coagulation
2012 - 2015 Generation of iPS cells from PAI-1 deficient patient and differentiation into mature cells
T. Brzoska, Y. Suzuki, H. Sano, M. Tomczyk, T. Urano. Imaging analyses of coagulation-dependent initiation of fibrinolysis on activated platelets and its modification by TAFI. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2015. 13. 11-11
T. Brzoska, Y. Suzuki, H. Mogami, H. Sano, T. Urano. Phosphatidylserine exposure on platelets'surface upon binding to rigid fibrin scaffold. JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2013. 11. 566-566
Tomasz Brzoska, Yuko Suzuki, Hideo Mogami, Hideto Sano, Tetsumei Urano. Binding of thrombin-activated platelets to a rigid fibrin network is essential for phosphatidylserine exposure on their cell surface. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S288-S288
