Research field (2)：
Tumor biology
, Gastroenterology
Research theme for competitive and other funds (4)：
2023 - 2026 Chronological sampling and molecular analyses of the ascites from patients with pancreatic cancer
2023 - 2026 血中反復配列RNAの高感度検出法を基盤とした早期膵癌診断戦略の構築
2022 - 2025 Molecular mechanisms of pancreatic cancer progression induced by structural alternation of nucleic acids.
2021 - 2024 Molecular functions of pancreatic oncogenesis induced by dysregulation of ubiquitin ligases.
Papers (60)：
Takuma Iwata, Takahiro Kishikawa, Takahiro Seimiya, Genso Notoya, Tatsunori Suzuki, Chikako Shibata, Yu Miyakawa, Nariaki Odawara, Kazuyoshi Funato, Eri Tanaka, et al. Satellite double-stranded RNA induces mesenchymal transition in pancreatic cancer by regulating alternative splicing. Journal of Biological Chemistry. 2024. 300. 3. 105742-105742
Yu Miyakawa, Motoyuki Otsuka, Chikako Shibata, Takahiro Seimiya, Keisuke Yamamoto, Rei Ishibashi, Takahiro Kishikawa, Eri Tanaka, Takayuki Isagawa, Norihiko Takeda, et al. Gut Bacteria-derived Membrane Vesicles Induce Colonic Dysplasia by Inducing DNA Damage in Colon Epithelial Cells. Cellular and molecular gastroenterology and hepatology. 2024. 17. 5. 745-767
Kazuyoshi Funato, Nozomi Miyake, Kazuma Sekiba, Yu Miyakawa, Takahiro Seimiya, Chikako Shibata, Takahiro Kishikawa, Motoyuki Otsuka. Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA. Hepatology communications. 2023. 7. 11
Chikako Shibata, Motoyuki Otsuka, Takayuki Shimizu, Takahiro Seimiya, Takahiro Kishikawa, Taku Aoki, Mitsuhiro Fujishiro. Extracellular vesicle-mediated RNA editing may underlie the heterogeneity and spread of hepatocellular carcinoma in human tissue and in vitro. Oncology reports. 2023. 50. 5
Sachiko Kanai, Hiroaki Fujiwara, Suguru Mizuno, Takahiro Kishikawa, Takuma Nakatsuka, Tsuyoshi Hamada, Mariko Tanaka, Junichi Arita, Yousuke Nakai, Hiroyuki Isayama, et al. Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2023
Motoyuki Otsuka, Rei Ishibashi, Eri Tanaka, Takahiro Seimiya, Tatsunori Suzuki, Kazuma Sekiba, Mari Yamagami, Motoko Ohno, Takahiro Kishikawa, Kazuhiko Koike. A tiny but crucial player bridging microbes and colonic carcinogenesis. TRANSLATIONAL CANCER RESEARCH. 2017. 6. S1467-S1470
MicroRNAs and liver disease (SPECIAL ISSUE : Dysregulated Non-coding RNAs and Human Diseases : A Fine-Tuner Changes into a Confuser). Journal of human genetics. 2017. 62. 1. 75-80
