Research keywords (7)：
around knee osteotomy
, total knee arthroplasty
, patient derived orthotopic xenografting (PDOX)
, osteosarcoma
, bone and soft tissue tumor
, knee surgery
, orthopaedic surgery
Research theme for competitive and other funds (5)：
2022 - 2025 Investigation of microenvironment and novel therapeutic targets in bone and soft tissue tumors
2020 - 2024 軟部肉腫に対する患者由来腫瘍同所移植マウスモデルを用いた個別化医療の開発
2019 - 2022 Investigation for mechanism of metastasis using molecular imaging
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung M Kang, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, Kentaro Igarashi, et al. Recombinant Methioninase Synergistically Reverses High-docetaxel Resistance Developed in Osteosarcoma Cells. Anticancer research. 2024. 44. 11. 4773-4778
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Recombinant Methioninase Increases Eribulin Efficacy 16-fold in Highly Eribulin-resistant HT1080 Fibrosarcoma Cells, Demonstrating Potential to Overcome the Clinical Challenge of Drug-resistant Soft-tissue Sarcoma. Anticancer research. 2024. 44. 9. 3777-3783
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung M Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Overcoming High Trabectedin Resistance of Soft-tissue Sarcoma With Recombinant Methioninase: A Potential Solution of a Recalcitrant Clinical Problem. Anticancer research. 2024. 44. 9. 3785-3791
Sei Morinaga, Qinghong Han, Kohei Mizuta, Byung Mo Kang, Motokazu Sato, Michael Bouvet, Norio Yamamoto, Katsuhiro Hayashi, Hiroaki Kimura, Shinji Miwa, et al. Recombinant Methioninase Is Selectively Synergistic With Doxorubicin Against Wild-type Fibrosarcoma Cells Compared to Normal Cells and Overcomes Highly-Doxorubicin-resistant Fibrosarcoma. Anticancer research. 2024. 44. 8. 3261-3268
Yohei Asano, Norio Yamamoto, Satoru Demura, Katsuhiro Hayashi, Akihiko Takeuchi, Satoshi Kato, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, et al. Combination therapy with immune checkpoint inhibitors and denosumab improves clinical outcomes in non-small cell lung cancer with bone metastases. Lung cancer (Amsterdam, Netherlands). 2024. 193. 107858-107858
