MATSUURA TORU

マツウラトオル | MATSUURA TORU

Affiliation and department：
Job title： Lecturer

Research field (3)： Developmental biology , Molecular biology , Cell biology

Research keywords (5)： Organoid , Feedback regulation , Synthetic biology , Stem cell , Circadian clock

Research theme for competitive and other funds (11)：

2024 - 2027 胆道がんに対するEphA2を標的とした抗体医薬の開発ー光感受物質と核酸医薬の融合ー
2023 - 2026 Establishment of renal cancer organoids based on pathological phenotype and development of novel therapeutic strategies
2022 - 2025 Adrenal regeneration
2022 - 2025 Cellular mechanisms of the mammalian implantation of embryos into the uterus
2019 - 2022 Circadian variations of cells in the colon cancer tissue

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Papers (40)：

Zha L, Matsu-Ura T, Sluka JP, Murakawa T, Tsuta K. Morphological basis of the lung adenocarcinoma subtypes. iScience. 2024. 27. 5. 109742
Andrew E Rosselot, Miri Park, Mari Kim, Toru Matsu-Ura, Gang Wu, Danilo E Flores, Krithika R Subramanian, Suengwon Lee, Nambirajan Sundaram, Taylor R Broda, et al. Ontogeny and function of the circadian clock in intestinal organoids. The EMBO Journal. 2022. 41. 2. e106973
Kang Kug (Paul) Lee, Toru Matsu-ura, Andrew E. Rosselot, Taylor R. Broda, James M. Wells, Christian I. Hong. An integrated microfluidic bubble pocket for long-term perfused three-dimensional intestine-on-a-chip model. Biomicrofluidics. 2021. 15. 1. 014110
Chan C, Ooashi N, Akiyama H, Fukuda T, Inoue M, Matsu-Ura T, Shimogori T, Mikoshiba K, Kamiguchi H. Inositol 1,4,5-Trisphosphate Receptor Type 3 Regulates Neuronal Growth Cone Sensitivity to Guidance Signals. iScience. 2020. 23. 3. 100963
Toru Matsu-ura, Hideki Shirakawa, Kenichi G. N. Suzuki, Akitoshi Miyamoto, Kotomi Sugiura, Takayuki Michikawa, Akihiro Kusumi, Katsuhiko Mikoshiba. Dual-FRET imaging of IP3 and Ca2+ revealed Ca2+-induced IP3 production maintains long lasting Ca2+ oscillations in fertilized mouse eggs. Scientific Reports. 2019. 9. 1. 4829-11

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MISC (6)：

Toru Matsu-ura, Andrey Dovzhenok, Sookyung Lim, Christian I. Hong. Development of Synthetic Gene Circuits to Amplify the Production of Biomaterials, Cellulases, and Lentivirus. BIOPHYSICAL JOURNAL. 2016. 110. 3. 317A-317A
Toru Matsu-Ura, Jill Pruszka, Eitaro Aihara, Andrey A. Dovzhenok, Marshall H. Montrose, Sookkyung Lim, Sean R. Moore, Christian Hong. Robust Coupling of Cell Cycle and Circadian Rhythms in Mouse Enteroids. GASTROENTEROLOGY. 2015. 148. 4. S157-S157
M. Arizono, H. Bannai, K. Nakamura, F. Niwa, M. Enomoto, T. Matsu-ura, A. Miyamoto, M. W. Sherwood, T. Nakamura, K. Mikoshiba. Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation. JOURNAL OF NEUROCHEMISTRY. 2012. 123. 116-116
Toru Matsu-ura, Sachiko Ishida, Takayiki Michikawa, Katsuhiko Mikoshiba. The Relationship Between Ip(3) Level and the Frequency of Ca2+ Oscillations. BIOPHYSICAL JOURNAL. 2011. 100. 3. 83-83
Takayuki Michikawa, Tadashi Shinohara, Masahiro Enomoto, Jun-Ichi Goto, Miwako Iwai, Toru Matsu-ura, Haruka Yamazaki, Akitoshi Miyamoto, Akio Suzuki, Katsuhiko Mikoshiba. Mechanistic basis of the bell-shaped dependence of inositol 1,4,5-trisphosphate receptor gating on cytosolic calcium. NEUROSCIENCE RESEARCH. 2011. 71. E84-E84

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Patents (6)：

AMPLIFIED PRODUCTION OF MONOCLONAL ANTIBODIES
Lentivirus Packaging System Comprising a Synthetic Positive Feedback Loop
NEUROSPORA CRASSA STRAINS WITH AMPLIFIED EXPRESSION OF CELLULASES AND PRODUCTION OF BIOFUEL THEREFROM
Endoplasmic reticulum cal-cium ATPase kinetics in-dicator and use thereof
A new IP3R binding protein and its application for IP3 indicator

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Books (3)：

Lectures and oral presentations (18)：

胚の着床率向上に寄与する薬剤の選別
(第13回スクリーニング学研究会 2022)
関西医科大学(KMU)オルガノイドバンクの取り組み
(第13回スクリーニング学研究会 2022)
Single cell RNA sequencing revealed circadian heterogeneity and circadian dependent cell population changes in mouse epithelial tissues
(日本時間生物学会学術大会 2021)
A new metabolic pathway of phosphoinositides
(The 43rd Annual Meeting of the Molecular Biology Society of Japan 2020)
Investigation of junctional epithelial stem/progenitor cells using the multicolor lineage tracing method
(The 63rd Annual Meeting of The Japanese Society of Periodontology 2020)

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Education (3)：

Professional career (1)：

Work history (5)：

2021/04 - 現在 Kansai Medical University Departmen of Pathology Assistant Professor
2018/04 - 2021/03 Kansai Medical University Department of Stem Cell Pathology Assistant Professor
2013/07 - 2018/03 University of Cincinnati Department of Physiology Research Scientist
2011/04 - 2013/06 Univeristy of Cincinnati Department of Pathology Research Scientist
2005/04 - 2011/03 RIKEN BSI Developmetal Neurobiology Research Scientist

Awards (8)：

2021 - Katano foundation Wada Kiyoko Award
2020 - Takeda science foundation Medical research fund
2016 - University of Cincinnati UC technology commercialization accelerator funding Phase II Amplified productions of biomaterials using synthetic biology.
2016 - Ohio Department of Higher Education Innovation Corps Ohio (I-CORPS@Ohio) Second-generation biofuel production with genetically engineered Neurospora crassa.
2015/05 - American Gastroenterological Association (AGA)/AGA-Gastroenterology Research Group (GRG) AGA/AGA-GRG Fellow Abstract Prize Robust Coupling of Cell Cycle and Circadian Rhythms in Mouse Enteroids

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Association Membership(s) (3)：

Biophysical Society , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , JAPANESE SOCIETY FOR CHRONOBIOLOGY

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