Takeishi Shoichiro

タケイシショウイチロウ | Takeishi Shoichiro

Affiliation and department：
Job title： Research Associate

Research field (4)： Clinical pharmacy , Physiology , Tumor biology , Hematology and oncology

Research keywords (14)： Hematopoietic stem cell , Leukemia stem cell , Cancer stem cell , Niche , Mesenchymal stem cell , Cell cycle , Quiescence , Ubiquitin ligase , CDK inhibitor , Fbxw7 , c-Myc , p21 , p27 , p57

Research theme for competitive and other funds (4)：

2015 - 2015 間葉系幹細胞の静止期維持機構の打破によるがん幹細胞の根絶.
2015 - 2015 細胞周期特性を利用した腸管幹細胞の純化と再生医療への応用.
2013 - 2015 がん幹細胞の静止期維持機構の解明.
2013 - 2014 Fbxw7阻害による大腸がん幹細胞の根絶.

Papers (11)：

Shimizu H, Takeishi S, Nakatsumi H, Nakayama KI. Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells. JCI Insight. 2019. 4. 4
Maryanovich M, Takeishi S, Frenette PS. Neural regulation of bone and bone marrow. Cold Spring Harb Perspect Med. 2018
Asada N, Takeishi S, Frenette PS (Corresponding aut. Complexity of bone marrow hematopoietic stem cell niche. Int J Hematol. 2017. 106. 1. 45-54
Takeishi S, Nakayama KI. To wake up cancer stem cells, or to let them sleep, that is the question. Cancer Sci. 2016. 107. 7. 875-881
Takeishi S, Nakayama KI. Role of Fbxw7 in the maintenance of normal stem cells and cancer-initiating cells. Br J Cancer. 2014. 111. 6. 1054-1059

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MISC (12)：

武石昭一郎. がん幹細胞における細胞周期制御. 日本臨牀. 2015. 73. 5. 779-783
武石昭一郎. p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling. 臨床血液. 2014. 55. 8. 976
武石昭一郎, 中山敬一. がん幹細胞の静止期維持機構とその破綻. Surgery Frontier. 2014. 21. 2. 58-60
武石昭一郎. Fbxw7による白血病幹細胞制御. 血液内科. 2014. 68. 2. 278-284
武石昭一郎, 中山敬一. 癌幹細胞の静止期維持機構. Surgery Frontier. 2013. 20. 4. 70-72

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Books (3)：

新版フローサイトメトリーもっと幅広く使いこなせる!
羊土社 2016
直伝! フローサイトメトリー面白いほど使いこなせる!
羊土社 2014
次世代がん戦略研究Update がん基盤生物学ー革新的シーズ育成に向けてー
南山堂 2013

Lectures and oral presentations (8)：

がんの親玉「がん幹細胞」の細胞周期に着目した新規がん治療戦略.
(JMSA New York Life Science Forum 2017 2017)
p57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling
(The 11th Kirinjuku 2015)
がん治療の真の標的「がん幹細胞」の静止期維持機構とその打破
(平成26年度京都大学原子炉実験所専門研究会 2014)
Fbxw7 prevents the G0-G1 transition to maitain quiescence in cancer stem cells
(Cold Spring Harbor Laboratory Meeting 2014)
Ablation of Fbxw7 eliminates leukemia-initiating cells by preventing quiescence
(2014)

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Education (2)：

2007 - 2011 Kyushu University Graduate School of Medical Sciences
1998 - 2004 Kyushu University School of Medicine

Professional career (2)：

MD (Kyushu University)
PhD (Kyushu University)

Work history (11)：

2021/02 - 現在 Albert Einstein College of Medicine Department of Cell Biology Research Associate
2015/10 - 2021/01 Albert Einstein College of Medicine Department of Cell Biology Research Fellow
2019/01 - 2020/08 Trainee for the NYSTEM Empire State Institutional Training Program in Stem Cell Research
2018/01 - 2018/12 The Uehara Memorial Foundation Research Fellow
2015/10 - 2017/10 Japan Society for the Promotion of Science Postdoctoral Fellow for Research Abroad

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Committee career (1)：

2016/10 - 2017/04 JMSA New York Life Science Forum JMSA New York Life Science Forum 2017 運営委員

Awards (3)：

2016/04 - JMSA New York Life Science Forum Best Poster Presentation Award
2015/08 - The Japanese Society of Hematology Incentive Award
2014/12 - Inoue Foundation for Science Inoue Research Award for Young Scientists

Association Membership(s) (4)：

The Japanese Society of Internal Medicine , The Japanese Society of Hematology , Japanese Society for Transplantation and Cellular Therapy , The Molecular Biology Society of Japan

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