Research field (6)：
Environmental impact assessment
, Veterinary medicine
, Hygiene and public health (non-laboratory)
, Hygiene and public health (laboratory)
, Environmental effects of chemicals
, Environmental effects of radiation
Research theme for competitive and other funds (16)：
2022 - 2025 IBD and Environmental factors
2021 - 2024 AHR ligands and humoral factors regulating human skin immune system
2017 - 2023 Environmental Stress
2015 - 2018 Application of MSD-AFLP method to explore epigenetic imprints focusing on exposure levels of environmental chemicals
2014 - 2017 Relationship between chemical exposure biomarkers and DNA methylation levels in the malformations of external reproductive system of young males
2011 - 2015 Epigenetic mutation induced by environmental factors: a molecular mechanism elucidation of the DOHaD
2011 - 2012 Molecular mechanism of programing of the adaptation to environment: search for the epigenomic modification alteration in the germ line
2008 - 2010 Postnatal carcinogenic risks of fetal stage exposure to environmental pollutants and its epigenetic molecular mechanism
2008 - 2010 Analysis of the toxicological effects of phthalate esters on testes by administration, culture and transplantation methods
2006 - 2008 Development study of the prediction system using mouse ES cells to detect next generation influences
2005 - 2006 Molecular mechanism of intracellular action of modifiers modulating the susceptibility to chemical exposure.
2002 - 2004 多種哺乳類のAh受容体遺伝子を用いたダイオキシン類の新しい評価法
2002 - 2003 魚類、両生類、哺乳類の不可逆化の臨界期探索
2000 - 2001 哺乳類の妊孕性と精細胞分子シャペロンの機能異常の関係についての研究
1997 - 1998 哺乳類雄性生殖細胞の温度感受性に関する分子生物学的解析
1996 - 1996 雄性生殖細胞分化過程における分子シャペロンを介したタンパク質輸送の研究
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Papers (82)：
Salvinaz Islam Moutusy, Seiichiroh Ohsako. Gut Microbiome-Related Anti-Inflammatory Effects of Aryl Hydrocarbon Receptor Activation on Inflammatory Bowel Disease. International journal of molecular sciences. 2024. 25. 6
Yusuke Kimura, Frederick Adams Ekuban, Cai Zong, Shigeyuki Sugie, Xiao Zhang, Ken Itoh, Masayuki Yamamoto, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihara. Role of Nrf2 in 1,2-dichloropropane-induced cell proliferation and DNA damage in the mouse liver. Toxicological Sciences. 2023. 195. 1. 28-41
Hirabayashi, T, Kawaguchi1, M, Harada, S, Mouri, M, Takamiya, R, Yoshimi, M, Sato, H, Taketomi, Y, Yokoyama, K, Kobayashi, T, et al. Hepatic phosphatidylcholine catabolism driven by PNPLA7 and PNPLA8 supplies endogenous choline to replenish the methionine cycle with methyl groups. Cell Rep. 2023. 42. 2. 111940
Abigail Ekuban, Cai Zong, Frederick Adams Ekuban, Yusuke Kimura, Ryoya Takizawa, Kota Morikawa, Kazuo Kinoshita, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihara. Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro. Toxics. 2021. 9. 6
Frederick Adams Ekuban, Cai Zong, Madoka Takikawa, Kota Morikawa, Toshihiro Sakurai, Sahoko Ichihara, Ken Itoh, Masayuki Yamamoto, Seiichiroh Ohsako, Gaku Ichihara. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. Toxicology. 2021. 456. 152785-152785
OHSAKO Seiichiroh, SUZUKI Soto, YADA Kentaro, UEHA Satoshi, CHEN Ming-Chen, OGIWARA Haru, MATSUSHIMA Kouji, ICHIHARA Gaku. Inflammatory bowel disease observed in the Ahr-null mice with an analysis of epigenome in genome-wide. Annual Meeting of the Japanese Society of Toxicology. 2020. 47.1. O-11
1991 - 1995 The University of Tokyo Graduate School of Agricultural and Life Sciences Veterinary Medical Sciences
1987 - 1991 The University of Tokyo
1983 - 1987 The University of Tokyo
Professional career (1)：
博士(獣医) (東京大学)
Work history (4)：
2006/01 - 現在 The University of Tokyo Graduate School of Medicine
1998/01 - 2005/12 国立環境研究所 環境健康研究領域 主任研究員
1995/08 - 1997/12 Kagoshima University Veterinary Medicine, Faculty of Agriculture
1995/04 - 1995/07 日本学術振興会特別研究員
Association Membership(s) (6)：
ISSCR
, 分子予防環境医学研究会
, THE JAPANESE SOCIETY FOR HYGIENE
, THE JAPANESE SOCIETY OF TOXICOLOGY
, THE JAPANESE SOCIETY OF VETERINARY SCIENCE
, Inamori Foundation
