2020 - 2025 Novel strategy to treat intractable CNS disorders, utilizing the properties of BBB-composing cells
2021 - 2024 Mechanism of breakdown of blood-brain barrier/blood-nerve barrier in neuroimmunological disorder
2017 - 2022 血液脳関門/血液神経関門を操作する新規モノクローナル抗体の作製
2018 - 2021 Discovery of new drug target modifiying the function of blood-brain barrier and blood-nerve barrier
2012 - 2015 Investigation into the mechanism of the blood-nerve barrier disruption in chronic inflammatory demyelinating polyradiculoneuropathy and multifocal motor neuropathy
2010 - 2011 The effect of advanced glycation end-products on blood-nerve barrier
2007 - 2008 Analysis of the function of the endothelial cells forming blood-nerve barrier
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Papers (102):
Fumitaka Shimizu. Bilateral External Ophthalmoplegia Induced by Herpes Zoster Ophthalmicus. Internal medicine (Tokyo, Japan). 2024. 63. 19. 2593-2594
Jordan Quellec, Camille Piro-Megy, Marion Cannac, Sébastien Nisole, Florent H Marty, Fabien Gosselet, Fumitaka Shimizu, Takashi Kanda, Catherine Cêtre-Sossah, Sara Salinas. Rift Valley fever virus is able to cross the human blood-brain barrier in vitro by direct infection with no deleterious effects. Journal of virology. 2024. e0126724
Rodrigo Azevedo Loiola, Johan Hachani, Sophie Duban-Deweer, Emmanuel Sevin, Paulina Bugno, Agnieszka Kowalska, Eleonora Rizzi, Fumitaka Shimizu, Takashi Kanda, Caroline Mysiorek, et al. Secretome of brain microvascular endothelial cells promotes endothelial barrier tightness and protects against hypoxia-induced vascular leakage. Molecular medicine (Cambridge, Mass.). 2024. 30. 1. 132-132
Masato Ohbuchi, Mayu Shibuta, Kazuhiro Tetsuka, Haruna Sasaki-Iwaoka, Masayo Oishi, Fumitaka Shimizu, Yasuhisa Nagasaka. Modeling of Blood-Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research. International journal of molecular sciences. 2024. 25. 12