Rchr
J-GLOBAL ID：201801006179471694   Update date: May. 22, 2024

Yasuda Tomokazu

Yasuda Tomokazu
Affiliation and department：
大阪大学大学院理学研究科化学専攻

About 大阪大学大学院理学研究科化学専攻


Job title： 特任助教
Research field  (3)： Molecular biochemistry ,  Bioorganic chemistry ,  Biophysics
Research keywords  (6)： エクソソーム ,  生物有機化学 ,  固体NMR ,  蛍光分光法 ,  脂質ラフト ,  生物物理化学
Research theme for competitive and other funds  (6)：
  • 2022 - 2025 生体モデル膜における脂質の膜動態解析に基づく脂質非対称性の生理的意義の解明
  • 2022 - 2023 膜脂質組成の改変技術を用いた細胞内取込を促進する高機能エクソソームの開発
  • 2019 - 2022 セラミド-1-リン酸の動的挙動解析に基づくホスホリパーゼA2分子認識機構の解明
  • 2021 - 2022 膜動態解析を基盤としたエクソソーム多様性と生体機能との相関の解明
  • 2020 - 2021 蛍光分光法によるエクソソームの膜動態解析
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Papers (26)：
  • Tomokazu Yasuda, Daiki Ueura, Madoka Nakagomi, Shinya Hanashima, J Peter Slotte, Michio Murata. Design, synthesis of ceramide 1-phosphate analogs and their affinity for cytosolic phospholipase A2 as evidenced by surface plasmon resonance. Bioorganic & medicinal chemistry letters. 2024. 107. 129792-129792
  • Hirofumi Watanabe, Shinya Hanashima, Yo Yano, Tomokazu Yasuda, Michio Murata. Passive Translocation of Phospholipids in Asymmetric Model Membranes: Solid-State 1H NMR Characterization of Flip-Flop Kinetics Using Deuterated Sphingomyelin and Phosphatidylcholine. Langmuir : the ACS journal of surfaces and colloids. 2023. 39. 43. 15189-15199
  • Yuichi Umegawa, Shiho Fukunaga, Tomokazu Yasuda, Michio Murata. A fluorescent probe of C24 fatty acid to report the deep interior of lipid bilayers. Synlett. 2023
  • Tomokazu Yasuda, J Peter Slotte, Michio Murata, Shinya Hanashima. Molecular Dynamics of Glycolipids in Liposomes. Methods in molecular biology (Clifton, N.J.). 2023. 2613. 257-270
  • Tomokazu Yasuda, Hirofumi Watanabe, Koichiro M Hirosawa, Kenichi G N Suzuki, Keishi Suga, Shinya Hanashima. Fluorescence Spectroscopic Analysis of Lateral and Transbilayer Fluidity of Exosome Membranes. Langmuir : the ACS journal of surfaces and colloids. 2022. 38. 48. 14695-14703
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MISC (28)：
  • 安田智一. Engineering Highly Functional Exosome Promoting Intracellular Uptake by Modifying Membrane Lipid Composition. 豊田研究報告(Web). 2023. 76
  • 花島慎弥, 花島慎弥, 安田智一, 樺山一哉, 廣澤幸一朗, 鈴木健一. Modification of membrane properties of small extracellular vesicle exosomes using lipid exchange. 日本化学会春季年会講演予稿集(Web). 2023. 103rd
  • LIAO Chia-Hui, HANASHIMA Shinya, YASUDA Tomokazu, MURATA Michio. Investigation of Inner Leaflet Lipids Influence on Sphingomyelin Domain. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
  • YASUDA Tomokazu, HIROSAWA Koichiro M., SUZUKI Kenichi G.N., KABAYAMA Kazuya, MURATA Michio, HANASHIMA Shinya. Elucidation of dynamic behavior of exosome membranes involved in intracellular uptake efficiency. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
  • 渡辺宏史, 花島慎弥, 安田智一, 村田道雄. Leaflet-specific quantification of choline lipids in the two layers of asymmetric vesicles. 日本化学会春季年会講演予稿集(Web). 2022. 102nd
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Education (3)：
  • 2012 - 2015 Osaka University
  • 2010 - 2012 Osaka University
  • 2006 - 2010 Osaka University School of Science Department of Chemistry
Work history (7)：
  • 2019/07 - 2022/12 Osaka University Graduate School of Science, Department of Chemistry
  • 2019/02 - 2019/06 Osaka University Graduate School of Science, Department of Chemistry
  • 2017/04 - 2019/02 Research Foundation Itsuu Laboratory
  • 2016/01 - 2017/03 Osaka University
  • 2015/06 - 2015/12 Åbo Akademi University Postdoctoral fellow
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Awards (1)：
  • 2022/04 - CREST細胞外微粒子 Young Innovator Award
Association Membership(s) (3)：
日本細胞外小胞学会 ,  日本生物物理学会 ,  日本化学会
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