Fukami Tatsuki

フカミタツキ | Fukami Tatsuki

Affiliation and department：
Job title：准教授

Research field (2)： Clinical pharmacy , Pharmaceuticals - health and biochemistry

Research keywords (4)： Drug metabolism , Drug-induced toxicity , non-P450 enzymes , Genetic polymorphisms

Research theme for competitive and other funds (11)：

2023 - 2026 Elucidation of the role of AADAC in protection against toxicity and biological homeostasis through regulation of iron concentration
2023 - 2023 薬効の個人差および毒性回避を目指したnon-P450アルコール基含有化合物酸化酵素の基盤情報の構築
2019 - 2022 AADACの毒性学的および病理学的意義の解明
2019 - 2020 食薬相互作用を利用した医薬品副作用の軽減戦略の構築
2018 - 2019 新規薬物代謝酵素アリルアセタミドデアセチラーゼの生理学的役割の解明

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Papers (169)：

Soshi Shinohara, Seijo Uchijima, Keiya Hirosawa, Mai Nagaoka, Masataka Nakano, Miki Nakajima, Tatsuki Fukami. Arylacetamide deacetylase regulates hepatic iron homeostasis to protect against carbon tetrachloride-induced ferroptosis. Archives of toxicology. 2024. 98. 12. 4059-4075
Rei Sato, Tatsuki Fukami, Kazuya Shimomura, Yongjie Zhang, Masataka Nakano, Miki Nakajima. Characterization of human alcohol dehydrogenase 4 and aldehyde dehydrogenase 2 as enzymes involved in the formation of 5-carboxylpirfenidone, a major metabolite of pirfenidone. Drug metabolism and disposition: the biological fate of chemicals. 2024
Shiori Hashiba, Masataka Nakano, Itsuki Yokoseki, Etsushi Takahashi, Masayuki Kondo, Yoichi Jimbo, Naoki Ishiguro, Hiroshi Arakawa, Tatsuki Fukami, Miki Nakajima. Cytochrome P450 and UDP-glucuronosyltransferase expressions, activities, and induction abilities in 3D-cultured human renal proximal tubule epithelial cells. Drug metabolism and disposition: the biological fate of chemicals. 2024
Shimon Nakashima, Tatsuki Fukami, Takashi Kudo, Masataka Nakano, Akiko Matsui, Naoki Ishiguro, Miki Nakajima. Iminium ion metabolites are formed from nintedanib by human CYP3A4. Drug metabolism and pharmacokinetics. 2024. 57. 101025-101025
Mai Nagaoka, Yoshiyuki Sakai, Miki Nakajima, Tatsuki Fukami. Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology. Biochemical pharmacology. 2024. 223. 116128-116128

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MISC (16)：

中野裕二朗, 仲吉朝希, 加藤紘一, 加藤紘一, 深見達基, 深見達基, 中島美紀, 中島美紀, 栗本英治, 小田彰史. Molecular dynamics simulation of human and canine carboxylesterase 2. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
Fukami Tatsuki, Nakajima Miki. SIGNIFICANCE OF ORPHAN ESTERASES IN CONTROL OF PHARMACOKINETICS AND DRUG TOXICITIES. DRUG METABOLISM AND PHARMACOKINETICS. 2018. 33. 1. S13-S14
佐々木永太, 飯田あずみ, 常山幸一, 深見達基, 中島美紀, 横井毅. カルバマゼピン誘導性肝障害モデルラットにおける免疫因子を介した発症機序の解明. J Toxicol Sci. 2014. 39. Supplement. S291-S291
A. Watanabe, T. Fukami, M. Nakajima, M. Takamiya, Y. Aoki, T. Yokoi. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis (Vol 37, pg 1513, 2009). DRUG METABOLISM AND DISPOSITION. 2014. 42. 6. 1066-1066
佐々木永太, 常山幸一, 深見達基, 中島美紀, 横井毅. フェニトイン誘導性肝障害マウスの作出と発症メカニズムの解明. J Toxicol Sci. 2013. 38. Supplement. S284

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Lectures and oral presentations (24)：

Effects of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation
(The 26th North American ISSX Meeting and 39th JSSX Meeting 2024)
Novel mechanism of drug-metabolizing hydrolases regulating the toxicity caused by reactive metabolites
(The 26th North American ISSX Meeting and 39th JSSX Meeting 2024)
Novel characteristics of non-P450 oxidases unraveled from functional analyses
(The 25th International Symposium on Microsomes and Drug Oxidations 2024)
機能解析から紐解かれたnon-P450酸化・還元酵素の新たな特徴
(第30回HAB研究機構学術年会 2023)
Characterization of enzymes determining the formations of acyl-glucuronidate and acyl-CoA conjugate
(The 37th Annual Meeting of the Japanese Society for the Study of Xenobiotics 2022)

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Education (3)：

2006 - 2008 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
2004 - 2006 Kanazawa University Graduate School of Natural Science and Technology
2000 - 2004 Kanazawa University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (金沢大学)

Work history (4)：

2015/02 - 現在 Kanazawa University Faculty of Pharmaceutical Sciences Associate Professor
2016/03 - 2016/12 National Institute of Health National Cancer Institute Special Volunteer
2008/10 - 2015/01 Kanazawa University Faculty of Pharmaceutical Sciences Assistant Professor
2006/04 - 2008/09 日本学術振興会特別研究員(DC1)

Committee career (7)：

2024/02 - 現在 "Drug Metabolism and Pharmacokinetics" Associate Editor
2023/02 - 現在 "Biochemical Pharmacology" Editorial Advisory Board
2021/01 - 現在 "Xenobiotica" Editorial Board
2019/10 - 現在 "Drug Metabolism Reviews" Editorial Board
2017 - 現在日本薬物動態学会代議員

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Awards (2)：

2018/10 - 日本薬物動態学会奨励賞
2014/11 - 日本薬学会北陸支部会学術奨励賞

Association Membership(s) (4)：

International Society for the Study of Xenobiotics , THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN

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