Fukami Tatsuki

フカミタツキ | Fukami Tatsuki

Affiliation and department：
Job title：准教授

Research field (2)： Clinical pharmacy , Pharmaceuticals - health and biochemistry

Research keywords (4)： Drug metabolism , Drug-induced toxicity , non-P450 enzymes , Genetic polymorphisms

Research theme for competitive and other funds (11)：

2023 - 2026 Elucidation of the role of AADAC in protection against toxicity and biological homeostasis through regulation of iron concentration
2023 - 2023 薬効の個人差および毒性回避を目指したnon-P450アルコール基含有化合物酸化酵素の基盤情報の構築
2019 - 2022 AADACの毒性学的および病理学的意義の解明
2019 - 2020 食薬相互作用を利用した医薬品副作用の軽減戦略の構築
2018 - 2019 新規薬物代謝酵素アリルアセタミドデアセチラーゼの生理学的役割の解明

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Papers (165)：

Mai Nagaoka, Yoshiyuki Sakai, Miki Nakajima, Tatsuki Fukami. Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology. Biochemical pharmacology. 2024. 223. 116128-116128
Yoshiyuki Sakai, Tatsuki Fukami, Shinsaku Tokumitsu, Masataka Nakano, Shimon Nakashima, Yuichiro Higuchi, Shotaro Uehara, Nao Yoneda, Hiroshi Suemizu, Miki Nakajima. Impact of miR-222-3p-mediated downregulation of arylacetamide deacetylase on drug hydrolysis and lipid accumulation. Drug Metabolism and Pharmacokinetics. 2024. 101007-101007
Shun Hayashi, Hiroko Kawaguchi, Takao Watanabe, Izuru Miyawaki, Tatsuki Fukami, Miki Nakajima. Prediction of combination effect of quinidine on the pharmacokinetics of tipepidine using a physiologically based pharmacokinetic model. Xenobiotica; the fate of foreign compounds in biological systems. 2024. 1-9
Keiya Hirosawa, Hijiri Fujioka, Gaku Morinaga, Tatsuki Fukami, Naoki Ishiguro, Wataru Kishimoto, Hiroshi Nakase, Hiroyuki Mizuguchi, Miki Nakajima. Quantitative Analysis of mRNA and Protein Expression Levels of Aldo-Keto Reductase and Short-Chain Dehydrogenase/Reductase Isoforms in the Human Intestine. Drug metabolism and disposition: the biological fate of chemicals. 2023. 51. 12. 1569-1577
Kiamu Kurosawa, Masataka Nakano, Itsuki Yokoseki, Mai Nagaoka, Seiya Takemoto, Yoshiyuki Sakai, Kaoru Kobayashi, Yasuhiro Kazuki, Tatsuki Fukami, Miki Nakajima. ncBAF enhances PXR-mediated transcriptional activation in the human and mouse liver. Biochemical pharmacology. 2023. 215. 115733-115733

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MISC (16)：

中野裕二朗, 仲吉朝希, 加藤紘一, 加藤紘一, 深見達基, 深見達基, 中島美紀, 中島美紀, 栗本英治, 小田彰史. Molecular dynamics simulation of human and canine carboxylesterase 2. 日本薬学会年会要旨集(CD-ROM). 2020. 140th (Web)
Fukami Tatsuki, Nakajima Miki. SIGNIFICANCE OF ORPHAN ESTERASES IN CONTROL OF PHARMACOKINETICS AND DRUG TOXICITIES. DRUG METABOLISM AND PHARMACOKINETICS. 2018. 33. 1. S13-S14
佐々木永太, 飯田あずみ, 常山幸一, 深見達基, 中島美紀, 横井毅. カルバマゼピン誘導性肝障害モデルラットにおける免疫因子を介した発症機序の解明. J Toxicol Sci. 2014. 39. Supplement. S291-S291
A. Watanabe, T. Fukami, M. Nakajima, M. Takamiya, Y. Aoki, T. Yokoi. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis (Vol 37, pg 1513, 2009). DRUG METABOLISM AND DISPOSITION. 2014. 42. 6. 1066-1066
佐々木永太, 常山幸一, 深見達基, 中島美紀, 横井毅. フェニトイン誘導性肝障害マウスの作出と発症メカニズムの解明. J Toxicol Sci. 2013. 38. Supplement. S284

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Lectures and oral presentations (21)：

機能解析から紐解かれたnon-P450酸化・還元酵素の新たな特徴
(第30回HAB研究機構学術年会 2023)
Characterization of enzymes determining the formations of acyl-glucuronidate and acyl-CoA conjugate
(The 37th Annual Meeting of the Japanese Society for the Study of Xenobiotics 2022)
機能解析から見えてきたnon-P450酸化および還元酵素の特徴
(薬物動態談話会第45年会 2022)
薬物動態および毒性の理解促進のための薬物代謝酵素基礎的知見
(日本薬物動態学会第36回年会 2021)
薬物代謝に関与する還元酵素の薬物還元反応に対する寄与率の評価および機能解析
(日本薬学会第141回年会 2021)

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Education (3)：

2006 - 2008 Kanazawa University Graduate School of Natural Science and Technology Division of Life Sciences
2004 - 2006 Kanazawa University Graduate School of Natural Science and Technology
2000 - 2004 Kanazawa University Faculty of Pharmaceutical Sciences

Professional career (1)：

博士(薬学) (金沢大学)

Work history (4)：

2015/02 - 現在 Kanazawa University Faculty of Pharmaceutical Sciences Associate Professor
2016/03 - 2016/12 National Institute of Health National Cancer Institute Special Volunteer
2008/10 - 2015/01 Kanazawa University Faculty of Pharmaceutical Sciences Assistant Professor
2006/04 - 2008/09 日本学術振興会特別研究員(DC1)

Committee career (7)：

2024/02 - 現在 "Drug Metabolism and Pharmacokinetics" Associate Editor
2023/02 - 現在 "Biochemical Pharmacology" Editorial Advisory Board
2021/01 - 現在 "Xenobiotica" Editorial Board
2019/10 - 現在 "Drug Metabolism Reviews" Editorial Board
2017 - 現在日本薬物動態学会代議員

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Awards (2)：

2018/10 - 日本薬物動態学会奨励賞
2014/11 - 日本薬学会北陸支部会学術奨励賞

Association Membership(s) (4)：

International Society for the Study of Xenobiotics , THE JAPANESE SOCIETY OF TOXICOLOGY , THE JAPANESE SOCIETY FOR THE STUDY OF XENOBIOTICS , THE PHARMACEUTICAL SOCIETY OF JAPAN

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