Fujikawa Makoto

フジカワマコト | Fujikawa Makoto

Affiliation and department：
Job title： Assistant Professor

Research field (5)： Pharmacology , Metabolism and endocrinology , Functional biochemistry , Molecular biology , Cell biology

Research keywords (6)： GPD2 (glycerol-3-phosphate dehydrogenase) , glycerol-phosphate shuttle , Alzheimer disease , cancer stem cell , FoF1-ATP synthase , energy metabolism

Research theme for competitive and other funds (5)：

2018 - 2019 糖尿病とアルツハイマー病の血液エネルギー代謝 -予防と先制医療のための早期診断を目指して-
2017 - 2019 膵島β細胞のインスリン分泌におけるミオシン軽鎖キナーゼの機能解析
2013 - 2015 Creation of novel anticancer lead compounds targeting receptor-type tyrosine kinase Met molecule
2012 - 2014 MASCアッセイ法を用いたエネルギー代謝関連遺伝子の機能同定
血球エネルギー代謝解析による認知症早期診断の開発研究

Papers (23)：

Makoto Fujikawa, Masashi Ueda, Kenta Maruyama. Role of Kynurenine and Its Derivatives in the Neuroimmune System. International journal of molecular sciences. 2024. 25. 13
Maimaiti Mikeli, Makoto Fujikawa, Tsutomu Tanabe. GPD2: The relationship with cancer and neural stemness. Cells & development. 2022. 173. 203824-203824
Takako Ikeda, Jun-Ichi Kishikawa, Yuki Hayashida, Makoto Fujikawa, Ken Yokoyama. Identification of chemical compounds as an inhibitor of mitochondrial ATP synthesis, leading to an increased stress resistance and an extended lifespan in C. elegans. Biochimica et biophysica acta. Bioenergetics. 2020. 148281-148281
Maimaiti Mikeli, Makoto Fujikawa, Kai Nagahisa, Shuhei Yasuda, Natsuhiko Yamada, Tsutomu Tanabe. Contribution of GPD2/mGPDH to an alternative respiratory chain of the mitochondrial energy metabolism and the stemness in CD133-positive HuH-7 cells. Genes to Cells. 2020. 25. 2. 139-148
Jun-ichi Kishikawa, Yuki Inoue, Makoto Fujikawa, Kenji Nishimura, Atsuko Nakanishi, Tsutomu Tanabe, Hiromi Imamura, Ken Yokoyama. General anesthetics cause mitochondrial dysfunction and reduction of intracellular ATP levels. PLoS ONE. 2018. 13. 1. e0190213

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MISC (3)：

藤川誠. 波紋疾走ほとばしる生命エネルギー. 日本生物工学会. 2014. 92. 4. 191-191
木岡秀隆, 加藤久和, 藤川誠, 鈴木俊治, 今村博臣, 野地博行, 吉田賢右, 北風政史, 朝野仁裕, 小室一成, et al. 低酸素により誘導されるミトコンドリアタンパク質MENTはATP合成を促進し低酸素から心臓を保護する. 日本臨床分子医学会学術総会プログラム・抄録集. 2013. 50回. 53-53
藤川誠, 横山謙. Regulatory mechanism of ATP synthase in mitochondria. 実験医学. 2009. 27. 7. 997-1003

Patents (1)：

ミトコンドリアの代謝活性測定方法

Lectures and oral presentations (23)：

グリセロール-リン酸シャトルを担う酵素はがんと神経細胞の幹細胞性に関与している
(第48回日本生体エネルギー研究会 2022)
GPD1/2 共役によるグリセロールリン酸シャトルががん幹細胞性に寄与している
(第46回日本生体エネルギー研究会 2020)
呼吸鎖XとしてのGPD2/mGPDHがCD133陽性HuH-7細胞のがん幹細胞性を支えている
(第45回日本生体エネルギー研究会 2019)
呼吸鎖XとしてのGPD2/mGPDHがCD133陽性HuH-7細胞のがん幹細胞性を支えている
(第42回日本分子生物学会年 2019)
The glycerol-3-phosphate dehydrogenase activity in Cancer Stem Cells
(第44回日本生体エネルギー研究会 2018)

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Education (4)：

2008 - Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biological Information
2001 - 2007 Tokyo Institute of Technology Graduate School of Bioscience and Biotechnology Department of Biological Information
1999 - 2001 Osaka University Graduate School of Engineering Department of Material and Life Science
1995 - 1999 Osaka University School of Engineering

Work history (7)：

2021/07 - 現在 Aichi Medical University School of Medicine assistant professor
2021/08 - 2022/03 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences - -
2018/04/01 - 2021/07/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Pharmacology and Neurobiology Assistant Professor
2014/04/01 - 2018/03/31 Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Medical and Dental Sciences Cognitive and Behavioral Medicine Pharmacology and Neurobiology Assistant Professor
2012/04 - 2014/03 Chuo University

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Awards (2)：

2014 - 東京医科歯科大学学長裁量優秀若手研究者奨励賞単一細胞のミトコンドリアエネルギー代謝測定系の開発と展開
2011 - 日本生体エネルギー研究会若手奨励賞 Screening of ATP-synthesis regulatory factors in human mitochondria by MASC assay

Association Membership(s) (2)：

日本細胞生物学会 , 日本分子生物学会

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