Morishima Tatsuya

モリシマタツヤ | Morishima Tatsuya

Affiliation and department：
Job title： Lecturer

Research field (2)： Fetal medicine/Pediatrics , Hematology and oncology

Research theme for competitive and other funds (13)：

2022 - 2024 tRNA修飾異常を起点とした赤血球プロテオスタシスの破綻
2021 - 2024 脂質代謝の適応獲得による白血病クローン生存機序の解明
2022 - 2023 ミトコンドリアtRNA 修飾酵素Mto1 による造血制御機構の解明
2022 - 2023 「先天性」好中球減少症の「後天的」発症機構
2021 - 2022 抗炎症薬のドラッグ・リポジショニングによる薬剤耐性白血病クローンの根絶

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Papers (28)：

Yu Wei Zhang, Talia Velasco-Hernandez, Julian Mess, Maria-Eleni Lalioti, Mari Carmen Romero-Mulero, Nadine Obier, Nikolaos Karantzelis, Jasmin Rettkowski, Katharina Schönberger, Noémie Karabacz, et al. GPRC5C drives branched-chain amino acid metabolism in leukemogenesis. Blood Advances. 2023. 7. 24. 7525-7538
Tatsuya Morishima, Koichi Takahashi, Desmond Wai Loon Chin, Yuxin Wang, Kenji Tokunaga, Yuichiro Arima, Masao Matsuoka, Toshio Suda, Hitoshi Takizawa. Phospholipid metabolic adaptation promotes survival of IDH2 mutant acute myeloid leukemia cells. Cancer Science. 2023. 115. 1. 197-210
Yuxin Wang, Tatsuya Morishima, Maiko Sezaki, Ryo Sato, Gaku Nakato, Shinji Fukuda, Kouji Kobiyama, Ken J Ishii, Yuhua Li, Hitoshi Takizawa. Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals. EMBO reports. 2023. 24. 12
Charlotte Flahou, Tatsuya Morishima, Natsumi Higashi, Yoshikazu Hayashi, Huaigeng Xu, Bo Wang, Chaoqi Zhang, Atsushi Ninomiya, Wei-Yin Qiu, Akinori Yuzuriha, et al. Humanized mouse models with endogenously developed human natural killer cells for in vivo immunogenicity testing of HLA class I-edited iPSC-derived cells. Biochemical and biophysical research communications. 2023. 662. 76-83
Maiko Sezaki, Yoshikazu Hayashi, Gaku Nakato, Yuxin Wang, Sayuri Nakata, Subinoy Biswas, Tatsuya Morishima, Md Fakruddin, Jieun Moon, Soyeon Ahn, et al. Hematopoietic stem and progenitor cells integrate microbial signals to promote post-inflammation gut tissue repair. The EMBO journal. 2022. 41. 22. e110712

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MISC (46)：

Benjamin Dannenmann, Maksim Klimiankou, Christian Lindner, Azadeh Zahabi, Regine Bernhard, Tatsuya Morishima, Cornelia Zeidler, Lothar Kanz, Karl Welte, Julia Skokowa. Analysis of Leukemogenic Effects of RUNX1 and CSF3R Mutations Using Congenital Neutropenia (CN)/AML Patient-Derived Induced Pluripotent Stem Cells (iPSCs). BLOOD. 2016. 128. 22
Tatsuya Morishima, Regine Bernhard, Azadeh Zahabi, Benjamin Dannenmann, Masoud Nasri, Bardia Samareh, Lothar Kanz, Karl Welte, Julia Skokowa. SIRT2 Plays Essential Role in Early Hematopoiesis through Deacetylation of LMO2 Protein. BLOOD. 2015. 126. 23
Azadeh Zahabi, Tatsuya Morishima, Andri Pramono, Dan Lan, Lothar Kanz, Karl Welte, Julia Skokowa. Thrombopoietin (TPO) Induces Hematopoietic Differentiation of Mouse ES Cells Via HIF-1 Alpha-Dependent Activation of a BMP4 Autoregulatory Loop. BLOOD. 2015. 126. 23
三上真充, 塩田光隆, 田中邦昭, 森嶋達也, 羽田敦子, 渡辺健, 秦大資. リンパ腫の治療中に気管腕頭動脈瘻を生じた重症心身障害児例. 日本小児科学会雑誌. 2015. 119. 5. 837-841
三上真充, 塩田光隆, 田中邦昭, 壹岐陽一, 本田吉孝, 森嶋達也, 村松秀城, 井澤和司, 高木正稔, 秦大資. JMMLとRALDの診断基準を同時に満たした1歳女児例. 日本小児科学会雑誌. 2014. 118. 2. 350-350

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Education (2)：

2007 - 2011 Kyoto University Graduate School of Medicine Graduate School of Medicine
1997 - 2003 Kyoto University Faculty of Medicine Department of Medical Science

Professional career (1)：

博士(医学) (京都大学)

Work history (11)：

2024/04 - 現在熊本大学国際先端医学研究機構若楠研究者 (Jr. PI)
2022/04 - 現在 Kumamoto University International Research Center for Medical Sciences Lecturer
2019/04 - 2022/03 Kumamoto University International Research Center for Medical Sciences Assistant Professor
2018/08 - 2019/03 Kumamoto University International Research Center for Medical Sciences Postdoctoral Fellow
2014/08 - 2018/07 University Hospital Tübingen Department of Internal Medicine II

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Awards (6)：

2017 - ASH Abstract Achievement Award
2017 - ISEH Travel Grant
2016 - Travel Grant for 21st Congress of the European Hematology Association
2016 - Ludwig Hiermaier Stiftung Travel grant
2015 - ASH Abstract Achievement Award

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Association Membership(s) (3)：

JAPAN PEDIATRIC SOCIETY , THE JAPANESE SOCIETY OF HEMATOLOGY , 日本分子生物学会

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