Rchr
J-GLOBAL ID:201801006402975810
Update date: Jun. 30, 2024
Irie Takashi
イリエ タカシ | Irie Takashi
Affiliation and department:
Job title:
Accociate Professor
Research field (1):
Virology
Research theme for competitive and other funds (15):
- 2017 - 2019 Development of a Novel Retroviral Vaccine Targeting Glycan Fluctuations
- 2017 - 2018 新コンセプト「ワクチン+アジュバント」ハイブリッドウイルスベクターの開発
- 2016 - 2018 Elucidation of interactions between paramyxoviral infection and host innate immunity
- 2013 - 2015 Elucidation of mechanisms of innate immune stimulation and evasion by RNA viruses
- 2012 - 2014 Analysis of structure and function of viral proteins that suppress innate immunity
- 2013 - 2013 生体の自然免疫系によるウイルス感染認識の実態を探る
- 2011 - 2012 Elucidation of mechanism for reorganization of host cytoskeletoninduced by Sendai virus matrix protein
- 2010 - 2012 アクセサリー蛋白質によるパラミクソウイルスの多面的な自然免疫回避戦略
- 2009 - 2011 Regulation of genome replication of negative-strand RNA virus by an accessory protein
- 2009 - 2010 Elucidation of mechanism for polarized regulation of viral RNA synthesis of negative-strand RNA viruses
- 2008 - 2008 モノネガウイルスのゲノム複製調節機構をターゲットとした新しい抗ウイルス剤開発のための基礎研究
- 2007 - 2008 Investigation of mechanism of paramyxovirus budding with accessory proteins by using vi rus reconstitution systems
- 2007 - 2008 Elucidation of unique cooperative action of multiple viral proteins for efficient virus budding
- 2006 - 2007 出芽におけるウイルス蛋白質の協調的作用と細胞骨格系の関与の解明
- 2006 - 2006 出芽におけるウイルスタンパク質の協調的作用と細胞骨格系の関与の解明
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Papers (47):
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Saito, Akatsuki, Irie, Takashi, Suzuki, Rigel, Maemura, Tadashi, Nasser, Hesham, Uriu, Keiya, Kosugi, Yusuke, Shirakawa, Kotaro, Sadamasu, Kenji, Kimura, Izumi, et al. Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation. NATURE. 2022. 602. 7896. 300-+
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Mlcochova, Petra, Kemp, Steven A., Dhar, Mahesh Shanker, Papa, Guido, Meng, Bo, Ferreira, Isabella A. T. M., Datir, Rawlings, Collier, Dami A., Albecka, Anna, Singh, Sujeet, et al. SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion. NATURE. 2021. 599. 7883. 114-+
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Yoriyuki Konno, Izumi Kimura, Keiya Uriu, Masaya Fukushi, Takashi Irie, Yoshio Koyanagi, Daniel Sauter, Robert J Gifford, So Nakagawa, Kei Sato. SARS-CoV-2 ORF3b Is a Potent Interferon Antagonist Whose Activity Is Increased by a Naturally Occurring Elongation Variant. Cell reports. 2020. 32. 12. 108185-108185
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Toshihito Nomura, Masaya Fukushi, Kosuke Oda, Akifumi Higashiura, Takashi Irie, Takemasa Sakaguchi. Effects of Traditional Kampo Drugs and Their Constituent Crude Drugs on Influenza Virus Replication In Vitro: Suppression of Viral Protein Synthesis by Glycyrrhizae Radix. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE. 2019. 2019
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Moriyama, Miyu, Igarashi, Manabu, Koshiba, Takumi, Irie, Takashi, Takada, Ayato, Ichinohe, Takeshi. Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity. JOURNAL OF VIROLOGY. 2018. 92. 19
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MISC (2):
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入江 崇, 酒井 宏治, 坂口 剛正. ウイルスベクターワクチンの現状と展望. BIO Clinica. 2019. 34. 2. 223-227
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Oda Kosuke, Ootake Rina, Matoba Yasuyuki, Irie Takashi, Sakaguchi Takemasa. 2P-068 Molecular mechanism of Sendai virus C protein to propagate the virus during the infection. 2015. 67. 191-191
Lectures and oral presentations (92):
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センダイウイルスの持続感染性獲得メカニズムの解明
(第69回日本ウイルス学会学術集会 2022)
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Latest findings on virology of Sendai virus
(2022)
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センダイウイルスを利用したSARS-CoV-2 S蛋白質の機能解析
(第68回日本ウイルス学会学術集会 2021)
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A regulatory mechanism of low expression of mononegavirus L protein by intergenic trinucleotide sequence and its significance.
(2021)
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センダイウイルス~基礎ウイルス学から応用へ~
(名古屋大学 第96回 創薬科学セミナー・GTRセミナー 2019)
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Awards (3):
- 2009/10/25 - 日本ウイルス学会理事長 日本ウイルス学会賞(杉浦奨励賞) エンベロープウイルスの粒子形成・出芽機構の解明
- 2008/08 - Travel grant for the 14th International Virology Congress Paramyxovirus Sendai virus C proteins are essential for maintenance of negative-sense RNA genome in virus particles
- 2005/06 - American Society for Microbiology American Society for Virology Postdoctoral Fellow Travel Grant Importance of sequences and host proteins for L-domain function in VSV recombinants
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