Shimizu Kouhei

シミズコウヘイ | Shimizu Kouhei

Affiliation and department：

Research field (5)： Pathobiochemistry , Medical biochemistry , Tumor biology , Chemical biology , Molecular biology

Research keywords (7)：炎症 , 細胞死 , がん , 創薬 , ユビキチン , プロテオスタシス , 翻訳後修飾

Research theme for competitive and other funds (13)：

2022 - 2026 複合型ユビキチン鎖を標的とした筋萎縮性側索硬化症の病態解明と創薬シーズの開拓
2024 - 2025 リニアユビキチンコードが制御する生体防御応答機構の解析と応用
2022 - 2025 新規RING型E3によるSkp2プロテオスタシス制御の破綻と発がん機構の解明
2021 - 2024 リニアユビキチンコードが制御する生体防御応答機構の解析と応用
2020 - 2022 Studies on a novel E3 ligase regulating LUBAC and host defense response

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Papers (25)：

Kouhei Shimizu, Hiroyuki Inuzuka, Fuminori Tokunaga. The interplay between cell death and senescence in cancer. Seminars in Cancer Biology. 2025. 108. 1-16
Daisuke Oikawa, Kouhei Shimizu, Fuminori Tokunaga. Pleiotropic Roles of a KEAP1-Associated Deubiquitinase, OTUD1. Antioxidants (Basel, Switzerland). 2023. 12. 2
Yusuke Sato, Seigo Terawaki, Daisuke Oikawa, Kouhei Shimizu, Yoshinori Okina, Hidefumi Ito, Fuminori Tokunaga. Involvement of heterologous ubiquitination including linear ubiquitination in Alzheimer's disease and amyotrophic lateral sclerosis. Frontiers in molecular biosciences. 2023. 10. 1089213-1089213
Daisuke Oikawa, Min Gi, Hidetaka Kosako, Kouhei Shimizu, Hirotaka Takahashi, Masayuki Shiota, Shuhei Hosomi, Keidai Komakura, Hideki Wanibuchi, Daisuke Tsuruta, et al. OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways. Cell Death & Disease. 2022. 13. 8
Kouhei Shimizu, Min Gi, Shugo Suzuki, Brian J North, Asami Watahiki, Satoshi Fukumoto, John M Asara, Fuminori Tokunaga, Wenyi Wei, Hiroyuki Inuzuka. Interplay between protein acetylation and ubiquitination controls MCL1 protein stability. Cell reports. 2021. 37. 6. 109988-109988

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MISC (6)：

清水康平, 魏民, 及川大輔, LINH Tran Thi Thuy, 小迫英尊, 高橋宏隆, 澤崎達也, 徳永文稔. 新規LUBAC結合E3による複合型ユビキチン鎖形成を介したネクロプトーシスの制御. 日本Cell Death学会学術集会プログラム抄録集. 2023. 31st
及川大輔, 魏民, 清水康平, 小迫英尊, 塩田正之, 高橋宏隆, 澤崎達也, 徳永文稔. ユビキチンワールドを制御する脱ユビキチン化酵素の疾患、創薬における重要性 OTUD1-KEAP1による炎症、酸化ストレス、細胞死制御と炎症性疾患抑制. 日本生化学会大会プログラム・講演要旨集. 2022. 95回. 2S04e-01
清水康平, GI Min, LINH Tran, 及川大輔, 小迫英尊, 高橋宏隆, 澤崎達也, 徳永文稔. Involvement of a novel LUBAC-associated protein on the regulation of cell death pathways. 日本分子生物学会年会プログラム・要旨集(Web). 2022. 45th
TRAN Thi Thuy Linh, 清水康平, 及川大輔, 高橋宏隆, 澤崎達也, 徳永文稔. A novel LUBAC-associated protein plays important roles in inflammatory response through regulation of programmed cell death. 日本生化学会大会(Web). 2021. 94th
K. Shimizu, T. Sawasaki. Analysis of caspase-dependent signaling pathway by a new method for high-throughput screening of protease substrates using a cell-free protein array: Nek5, a novel substrate for caspase-3, promotes skeletal muscle differentiation by up-regulating caspase-3 activity. MOLECULAR BIOLOGY OF THE CELL. 2013. 24

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Professional career (1)：

博士(工学) (愛媛大学)

Work history (9)：

2024/10 - 現在 Osaka Metropolitan University
2022/04 - 2024/09 Osaka Metropolitan University
2019/10 - 2022/03 Osaka City University Graduate School of Medicine
2017/01 - 2019/09 Tohoku University Graduate School of Dentistry
2017/01 - 2017/05 Harvard Medical School Department of Pathology, Beth Israel Deaconess Medical Center 日本学術振興会海外特別研究員

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Awards (4)：

2023/08 - The 3rd Japan and Australia Meeting on Cell Death (JAM2023) 1st Prize Poster Presentation LUBAC and its associated ubiquitin ligase generate heterotypic ubiquitin chains to inhibit necroptosis
2023/07 - 日本Cell Death学会ベストプレゼンテーション賞新規LUBAC結合E3による複合型ユビキチン鎖形成を介したネクロプトーシスの制御
2022/03 - 大阪市立大学医学部 2021年度 Teacher of the Year
2017/09 - Young Researchers’ Meeting Best Presentation Award The role of acetylation in the regulation of MCL1 stability

Association Membership(s) (3)：

日本Cell Death学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , 日本生化学会

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