Mukai Tomoyuki

ムカイトモユキ | Mukai Tomoyuki

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://m.kawasaki-m.ac.jp/classroom/course.php?id=208

Research field (3)： Immunology , Allergies and connective tissue disease , Dermatology

Research keywords (7)： EBI3 , VEXAS症候群 , RNA編集 , 関節リウマチ , 炎症性皮膚疾患 , 遺伝性免疫疾患 , 自己炎症性疾患

Research theme for competitive and other funds (11)：

2024 - 2027 成人T細胞白血病に対するCRISPR-Cas13を用いた遺伝子治療戦略の開発
2024 - 2027 成人自己炎症性疾患VEXAS症候群の病態解明およびCas13を用いた革新的遺伝子治療の開発
2023 - 2026 一次繊毛KIF7分子の関節炎への役割の検討と治療への応用
2023 - 2026 Mechanisms of reciprocal regulation of immune diseases by EBI3-containing heterodimer cytokines
2022 - 2025 関節リウマチにおけるDNAメチル化ダイナミズムの解明とエピゲノム創薬に向けて

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Papers (90)：

Masanori Iseki, Yuma Sakamoto, Daiki Takezaki, Yoshihiro Matsuda, Mariko Inoue, Shin Morizane, Tomoyuki Mukai. Epstein-Barr virus induced 3 attributes to TLR7-mediated splenomegaly and bicytopenia. 2024
Tomoyuki Mukai, Takahiko Akagi, Sumie Hiramatsu Asano, Ikue Tosa, Mitsuaki Ono, Mizuho Kittaka, Yasuyoshi Ueki, Ayano Yahagi, Masanori Iseki, Toshitaka Oohashi, et al. Imatinib has minimal effects on inflammatory and osteopenic phenotypes in a murine cherubism model. Oral diseases. 2023. 29. 3. 1089-1101
Riko Takimoto-Ito, Naotomo Kambe, Toshiaki Kogame, Takashi Nomura, Kazushi Izawa, Tomoyasu Jo, Yasuhiro Kazuma, Hajime Yoshifuji, Yuya Tabuchi, Hiroyasu Abe, et al. Summary of the current status of clinically diagnosed cases of Schnitzler syndrome in Japan. Allergology international : official journal of the Japanese Society of Allergology. 2023. 72. 2. 297-305
Tomoyuki Mukai, Hiroaki Ida, Yasuyoshi Ueki, Ryuta Nishikomori. Editorial: A new frontier in translational research on autoinflammatory diseases - various aspects of innate immunity on human diseases. Frontiers in immunology. 2023. 14. 1147202-1147202
Daiki Takezaki, Shin Morizane, Kenta Ikeda, Masanori Iseki, Yuma Sakamoto, Yoshio Kawakami, Taishi Hashiguchi, Yuka Shirakata, Sohji Nishina, Tomoyuki Mukai. Co-occurrence of non-alcoholic steatohepatitis exacerbates psoriasis associated with decreased adiponectin expression in a murine model. Frontiers in immunology. 2023. 14. 1214623-1214623

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MISC (11)：

向井知之, 池田賢太, 森実真, 赤木貴彦, 浅野澄恵, 立花宏太, 矢作綾野, 井関將典, 金藤秀明, 和田淳, et al. 肥満・高脂血症は相乗的に乾癬様皮疹を悪化する. 日本臨床免疫学会総会プログラム・抄録集. 2022. 50回. 99-99
Shintaro Yamamoto, Shunichi Fujita, Tomoyuki Mukai. Paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome should be treated with low-dose prednisolone during pembrolizumab therapy. Internal Medicine. 2020. 59. 4. 597-598
向井知之, 辻尚子, 松崎秀紀, 井関將典, 長洲晶子, 平野紘康, 石原克彦, 上田尚靖, 本田吉孝, 堀内孝彦, et al. 免疫不全 TNF受容体関連周期性症候群(TRAPS)患者におけるG87V変異TNFRSF1Aの同定と機能解析. 日本臨床免疫学会総会プログラム・抄録集. 2019. 47回. 83-83
Yoshiko Hada, Haruhito A. Uchida, Tomoyuki Mukai, Fumiaki Kojima, Nozomu Otaka, Yasuhiro Onishi, Yoshitaka Morita, Yoichiro Iwakura, Jun Wada. Inhibition of Interleukin-6 Signaling on Aortitis in Interleukin-1 Receptor Antagonist Deficient Mice. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019. 39
Shunichi Fujita, Hiroaki Hayashi, Shoko Kodama, Tomoyuki Mukai, Yoshitaka Morita. Infection of Helicobacter cinaedi Should Be Treated for an Adequate Duration with Combined Antibiotic Therapy: Author’s reply. Internal Medicine. 2019. 58. 17. 2591

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Lectures and oral presentations (269)：

Concomitant Nonalcoholic Steatohepatitis Worsens Psoriasis Associated with Decreased Adiponectin Expression in a Mouse Model
(The 52nd Annual Meeting of the Japanese Society for Immunology 2024)
The cytokine component Epstein-Barr virus induced 3 (EBI3) promotes systemic inflammation induced by TLR7 ligand
(The 52nd Annual Meeting of the Japanese Society for Immunology 2024)
非アルコール性脂肪性肝炎の併存はマウスモデルにおける乾癬を悪化させる
(第46回日本分子生物学会年会 2023)
サイトカイン構成要素EBI3はTLR7リガンドによって誘導される炎症の増悪因子として機能する
(第46回日本分子生物学会 2023)
複雑核型を有する骨髄異形成症候群に合併した巨細胞性動脈炎症例
(第34回日本リウマチ学会中国・四国支部学術集会 2023)

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Education (1)：

Professional career (1)：

Committee career (3)：

Awards (10)：

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Association Membership(s) (8)：

日本臨床免疫学会 , 日本筋学会 , 日本リウマチ学会 , 日本分子生物学会 , 日本内科学会 , 日本免疫学会 , 日本人類遺伝学会 , 日本免疫不全・自己炎症学会

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