Abe-Dohmae Sumiko

ドウマエスミコ | Abe-Dohmae Sumiko

Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research theme for competitive and other funds (26)：

2023 - 2026 食品中の抗動脈硬化活性成分総合的研究
2020 - 2023 機能性食品に注目したHDLの栄養学的代謝制御
2019 - 2023 ABCタンパク質による炎症反応制御と脂質栄養
2016 - 2019 Elucidation of a role of age-related lipid accumulation on Bruch's membrane in the pathogenesis of age-related macular degeneration
2013 - 2017 ABCA1 and ABCA7: what are their roles in the pathogenesis of Alzheimer's disease?

2012 - 2016 Changes in behevior and cell membrane structure in the central nerous sysytem of apoE- and ABC A1-deficient mice

2009 - 2011 Roles of ABC transporters in cellular cholesterol transport and inflammatory response

2009 - 2011 Clarification of the genes involved in the hyperlipidemia and the application to the preventive medicine

2007 - 2008 HDL generation as an effector against inflammation and atherosclerosis

2005 - 2006 Mechanism of cellular cholesterol release

2004 - 2004 脳内HDLの機能;脳コレステロール輸送と障害の修復

2003 - 2004 Elucidation of HDL generation mechanism in hepatocytes

2003 - 2003 脳内HDLの機能:脳コレステロール輸送と障害の修復

2002 - 2003 Mechanism of HDL Generation

2002 - 2003 Molecular Basis of Intracellular Cholesterol Homeostasis and Genration of HDL

2001 - 2001 脳内HDLの機能;脳コレステロール代謝平衡と障害の修復

2000 - 2001 Mechanism of Cellular Cholesterol Release

2000 - 2001 Molecular Basis of Intracellular Cholesterol Homeostasis

2000 - 2001 脳内HDLの機能:脳ステロール代謝平衡と障害の修復

1998 - 1999 Homeostasis and its pathology of cellular lipid

1997 - 1998 細胞コレステロール搬出を制御するアポリポタンパク質レセプターの同定と機能の解析

1997 - 1998 Enhancement of cellular cholesterol efflux and atherosclerosis treatwent by pharmacological stimulation of an apolipoprotein receptor(s)

1997 - 1998 Mechanism for cellular cholesterol remoral mediated by an apolipoprotein receptor(s)

1996 - 1996 脳の性分化決定機構の分子生物学的な解析

1995 - 1995 脳の性分化決定機構の解析-性中枢領域の神経細胞におけるアロマターゼ遺伝子発現制御機構の解明-

1993 - 1993 中枢神経系におけるbcl-2遺伝子の機能

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Papers (54)：

Yoshio Yamauchi, Sumiko Abe-Dohmae, Noriyuki Iwamoto, Ryuichiro Sato, Shinji Yokoyama. ABCA1 deficiency causes tissue-specific dysregulation of the SREBP2 pathway in mice. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 2024. 1869. 8. 159546-159546
Tomoe Tsuboi, Rui Lu, Takayuki Yonezawa, Akio Watanabe, Je-Tae Woo, Sumiko Abe-Dohmae, Shinji Yokoyama. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020. 297. 32-39
坪井知恵, 呂鋭, 米澤貴之, 渡辺章夫, 禹済泰, 堂前純子, 横山信治. 柑橘類果皮由来機能性成分ノビレチンによるABCA1・ABCG1活性制御. 日本動脈硬化学会総会プログラム・抄録集. 2019. 51回. 1-4
楠本嵩志, 市野晨人, 西辻和親, 坂下直実, 堂前純子, 奥平桂一郎. 膜タンパク質ABCA7の発現を調節する化合物の探索. 日本薬学会年会要旨集. 2018. 138年会. 3. 110-110
Yukako Isobe-Sasaki, Michio Fukuda, Yoshiaki Ogiyama, Ryo Sato, Toshiyuki Miura, Daisuke Fuwa, Masashi Mizuno, Tetsuhei Matsuoka, Hiroko Shibata, Hiroyuki Ito, et al. Sodium balance, circadian BP rhythm, heart rate variability, and intrarenal renin-angiotensin-aldosterone and dopaminergic systems in acute phase of ARB therapy. Physiological Reports. 2017. 5. 11

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MISC (26)：

Sumiko Abe-Dohmae, Shinji Yokoyama. ABCA7 links sterol metabolism to the host defense system: Molecular background for potential management measure of Alzheimer's disease. Gene. 2021. 768
坪井知恵, 呂鋭, 米澤貴之, 渡辺章夫, 禹済泰, 禹済泰, 堂前純子, 横山信治. ノビレチンによるABCA1・ABCG1を介したHDL産生促進の情報伝達分子機構. 日本動脈硬化学会総会・学術集会プログラム・抄録集(Web). 2020. 52nd
市野晨人, 楠本嵩志, 西辻和親, 坂下直実, 堂前純子, 奥平桂一郎, 奥平桂一郎. 膜トランスポーターABCA7の筋肉における新たな機能. 膜シンポジウム. 2017. 29
Sumiko Abe-Dohmae, Shinji Yokoyama. ABCA7: a potential mediator between cholesterol homeostasis and the host defense system. CLINICAL LIPIDOLOGY. 2012. 7. 6. 677-687
岩本紀之, 堂前純子, 横山信治. PKD/AP-2によるABCA1と adiponectin の遺伝子発現の共通情報伝達系. 脂質生化学研究. 2011. 53. 216-219

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Lectures and oral presentations (1)：

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