Muroi Makoto

Affiliation and department：
Research theme for competitive and other funds (13)：

2020 - 2025 Science of fairy chemicals and their application development
2021 - 2024 人工知能を活用した抗真菌剤の開発研究
2020 - 2023 プロテオーム解析を用いた直接的アプローチ法による薬剤標的同定解析システムの開発
2017 - 2020 Development of compound evaluation system based on pathway analysis using proteome analysis
2015 - 2017 Molecular mechanism of neuroprotective activity of geldanamycin

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Papers (60)：

Chiharu Okuda, Yuto Ueda, Makoto Muroi, Emiko Sanada, Hiroyuki Osada, Yoshihito Shiono, Ken-Ichi Kimura, Kenji Takeda, Koichiro Kawaguchi, Takao Kataoka. Allantopyrone A interferes with the degradation of hypoxia-inducible factor 1α protein by reducing proteasome activity in human fibrosarcoma HT-1080 cells. The Journal of antibiotics. 2023. 76. 6. 324-334
Makoto Kawatani, Harumi Aono, Sayoko Hiranuma, Takeshi Shimizu, Makoto Muroi, Toshihiko Nogawa, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Kanami Yamazaki, et al. Identification of a dihydroorotate dehydrogenase inhibitor that inhibits cancer cell growth by proteomic profiling. Oncology research. 2023. 31. 6. 833-844
Hiromasa Yoshioka, Tatsuro Kawamura, Makoto Muroi, Yasumitsu Kondoh, Kaori Honda, Makoto Kawatani, Harumi Aono, Herbert Waldmann, Nobumoto Watanabe, Hiroyuki Osada. Identification of a Small Molecule That Enhances Ferroptosis via Inhibition of Ferroptosis Suppressor Protein 1 (FSP1). ACS Chemical Biology. 2022. 17. 2. 483-491
Majid Manzoor, Makoto Muroi, Naoko Ogawa, Hiroki Kobayashi, Haruna Nishimura, Danni Chen, Opeyemi B. Fasina, Jianyu Wang, Hiroyuki Osada, Minoru Yoshida, et al. Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo. Food & Function. 2022
Ju Yeon Moon, Eri Adams, Takae Miyazaki, Yasumitsu Kondoh, Makoto Muroi, Nobumoto Watanabe, Hiroyuki Osada, Ryoung Shin. Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana. Scientific Reports. 2021. 11. 1

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MISC (21)：

Makoto Muroi, Hiroyuki Osada. Proteomics-based target identification of natural products affecting cancer metabolism. Journal of Antibiotics. 2021. 74. 10. 639-650
河村達郎, 河村達郎, 二村友史, 室井誠, 室井誠, 川谷誠, 川谷誠, SHANG Rchang, JANNING Petra, 近藤恭光, et al. がん細胞に活性酸素種産生を誘導する化合物RKN9055の発見と作用解析. 日本農芸化学会大会講演要旨集(Web). 2019. 2019
佐竹華子, 佐竹華子, 二村友史, 室井誠, 野川俊彦, 川谷誠, 井本正哉, 長田裕之. がん代謝研究を加速するオミックス解析基盤の構築. 日本農芸化学会大会講演要旨集(Web). 2018. 2018
T. Kawamura, M. Kawatani, M. Muroi, Y. Kondoh, Y. Futamura, H. Aono, M. Tanaka, K. Honda, H. Osada. Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. EUROPEAN JOURNAL OF CANCER. 2016. 69. S76-S77
T. Kawamura, Y. Kondoh, M. Muroi, M. Kawatani, H. Osada. NPD926, a small molecule inducer of reactive oxygen species, kills cancer cells via glutathione depletion. EUROPEAN JOURNAL OF CANCER. 2014. 50. 14-14

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