Takuji Ohyama

オオヤマタクジ | Takuji Ohyama

Affiliation and department：
Job title： Professor
Homepage URL (1)： https://takujioyama1970.wordpress.com/

Research field (1)： Structural biochemistry

Research keywords (3)： Nuclear receptor , DNA replication and repair , X-ray Crystallography

Research theme for competitive and other funds (1)：

2006 - 2010 Structural basis of functional coupling between transcription and cellular metabolism

Papers (72)：

Akihiro Honda, Shotaro Kamata, Makoto Akahane, Yui Machida, Kie Uchii, Yui Shiiyama, Yuki Habu, Saeka Miyawaki, Chihiro Kaneko, Takuji Oyama, et al. Functional and Structural Insights into Human PPARα/δ/γ Subtype Selectivity of Bezafibrate, Fenofibric Acid, and Pemafibrate. 2022. 23. 9. 4726
Zengwei Liao, Takuji Oyama, Yumi Kitagawa, Katsuo Katayanagi, Kosuke Morikawa, Masayuki Oda. Pivotal role of a conserved histidine in Escherichia coli ribonuclease HI as proposed by X-ray crystallography. Acta Crystallographica Section D Structural Biology. 2022. 78. 3. 390-398
Takuji Oyama, Kazuki Takiguchi, Hiroyuki Miyachi. Crystal structures of the ligand-binding domain of human peroxisome proliferator-activated receptor δ in complexes with phenylpropanoic acid derivatives and a pyridine carboxylic acid derivative. Acta crystallographica. Section F, Structural biology communications. 2022. 78. Pt 2. 81-87
Keisuke Oki, Mariko Nagata, Takeshi Yamagami, Tomoyuki Numata, Sonoko Ishino, Takuji Oyama, Yoshizumi Ishino. Family D DNA polymerase interacts with GINS to promote CMG-helicase in the archaeal replisome. NUCLEIC ACIDS RESEARCH. 2021. 50. 7. 3601-3615
Oyama T, Kamata S, Ishii I, Miyachi H. Crystal structures of the human peroxisome proliferator-activated receptor (PPAR)α ligand-binding domain in complexes with a series of phenylpropanoic acid derivatives generated by a ligand-exchange soaking method. BIOLOGICAL & PHARMACEUTICAL BULLETIN. 2021. 44. 9. 1202-1209

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MISC (26)：

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Books (1)：

Lectures and oral presentations (5)：

Toward high-throughput crystal structure determination of PPAR ligand-binding domain in complex with insoluble ligands
(Symposium in the 142th Annual Meeting of the Parmaceutical Society of Japan 2022)
プレスリリース:アーキア(古細菌)のDNA合成酵素が鋳型DNAの二本鎖を解く機能に貢献!〜アーキア(古細菌)がどのように DNA を複製するのかを解明〜
(2021)
Crystal structure of the PPAR delta binding domain in complex with the partial agonist JK122
(The Regular Meeting of The Japanese Biochemical Society, Kanto Branch 2013)
Crystal structure of the cytoplasmic dynein motor domain
(Annual Meeting of the Crystallographic Society of Japan 2011 2011)
Molecular mechanism of DNA replication and repair based on three-dimensional structure: focusing on the clamp-loading complex
(Symposium in the 6th Annual Meeting of Protein Science Socity of Japan 2006)

Professional career (1)：

Work history (8)：

2015/04/01 - Faculty of Life and Environmental Sciences, University of Yamanashi Associate Professor
2012/04/01 - 2015/03/31 Faculty of Life and Environmental Sciences, University of Yamanashi Department of Biotechnology Assitant Professor
2011/04/01 - Institute for Protein Research, Osaka University Laboratory of Protein Crystallography Specially Appointed Researcher
2008/10/01 - 2011/03/31 Institute for Protein Research, Osaka University Laboratory of Protein Organic Chemistry Specially Appointed Researcher
2005/10/01 - 2008/09/30 Institute for Protein Research, Osaka University Biomolecular Recognition (Takara-Bio) Endowed Division Assitant Professor

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Committee career (1)：

2016/08/01 - 2018/07/31 独立行政法人日本学術振興会特別研究員等審査会専門委員、卓越研究員候補者選考委員会書面審査員及び国際事業委員会書面審査員・書面評価員

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