NAKAMURA YOKI

ナカムラヨウキ | NAKAMURA YOKI

Affiliation and department：
Job title： Assistant professor

Research field (1)： Pharmacology

Research keywords (8)： Microglia , Cellular senescence , Sigma receptor , High mobility group box 1 , Cognitive dysfunction , Psychiatric disorder , Neuropathic pain , Trigeminal neuropathy

Research theme for competitive and other funds (8)：

2022 - 2025 慢性疼痛における核内受容体RORsの機能解析と新規治療戦略への応用
2022 - 2025 ミクログリアの細胞老化現象に着目した認知機能障害の発症・増悪機構の解明と応用
2023 - 2025 細胞老化ミクログリアに着目した老年期精神神経疾患の病態形成メカニズムの解明と新規治療薬の開発
2023 - 2025 パーキンソン病に付随する難治性疼痛発症機構の解明と新規鎮痛薬の創製
2020 - 2023 前帯状皮質ミクログリアに着目した慢性疼痛の病態解明と新規創薬ターゲットの探索

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Papers (59)：

Norimitsu Morioka, Yoki Nakamura, Kazue Hisaoka-Nakashima, Yoshihiro Nakata. High mobility group box-1: A therapeutic target for analgesia and associated symptoms in chronic pain. Biochemical Pharmacology. 2024. 222. 116058-116058
Simeng Ma, Yoki Nakamura, Takahiro Kochi, Suzuna Uemoto, Kazue Hisaoka-Nakashima, Dengli Wang, Keyue Liu, Hidenori Wake, Masahiro Nishibori, Norimitsu Morioka. Perineural Treatment with High Mobility Group Box-1 Monoclonal Antibody Prevents Initiation of Pain-Like Behaviors in Female Mice with Trigeminal Neuropathy. Biological and Pharmaceutical Bulletin. 2024. 47. 1. 221-226
Hiroki Hashizume, Hatsune Motonari, Kenta Yamamoto, Yoki Nakamura, Kazue Hisaoka-Nakashima, Norimitsu Morioka. Stimulation of nuclear receptor REV-ERBs alleviates monosodium iodoacetate-induced osteoarthritis pathology of mice and the induction of inflammatory molecules expression in primary cultured chondrocytes. International Immunopharmacology. 2024. 127. 111349-111349
Yoki Nakamura. Investigation of Chronic Pain for the Development of Novel Analgesics Focusing on High Mobility Group Box-1. YAKUGAKU ZASSHI. 2024. 144. 1. 15-18
Thu Nguyen Dang, Son Nguyen Tien, Ryosuke Ochi, Duc Le Trung, Kyo Nishio, Hiroki Kuwamura, Tomoyuki Kurose, Naoto Fujita, Hisao Nishijo, Yoki Nakamura, et al. Enhanced anxiety-like behavior induced by chronic neuropathic pain and related parvalbumin-positive neurons in male rats. Behavioural Brain Research. 2023. 114786-114786

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Books (1)：

別冊 BIO Clinica 慢性炎症と疾患
(株)北隆館 2019

Lectures and oral presentations (204)：

三叉神経損傷後の冷刺激過敏化に対するカンナビノイド CB2 アゴニストの効果
(日本薬学会第144年会 2024)
ミクログリアの細胞老化に着目した老化マウスのうつ・不安様症状の解析
(日本薬学会第144年会 2024)
神経障害性疼痛モデルマウスにおける不安・うつ様行動に対するHMGB1中和抗体経鼻投与の効果の検討
(日本薬学会第144年会 2024)
核内受容体 RORγ 阻害薬はミクログリア活性を抑制することで疼痛緩和効果を示す
(日本薬学会第144年会 2024)
ラット初代培養軟骨細胞における機械的刺激による炎症反応の増強作用メカニズムの検討
(日本薬学会第144年会 2024)

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Education (3)：

2010 - 2013 Hiroshima University Graduate School of Biomedical Sciences Doctoral Course
2008 - 2010 Hiroshima University Graduate School of Biomedical Sciences Master's Course
2004 - 2008 Fukuyama University

Professional career (1)：

Doctor of Philosophy in Pharmaceutical Science (Hiroshima University)

Work history (4)：

2019/04 - 現在 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant professor
2018/02 - 2019/03 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2013/11 - 2018/01 National Institute on Drug Abuse Cellular Pathobiology Section Visiting Fellow
2013/04 - 2013/10 Hiroshima University Institute of Biomedical & Health Sciences Post doctoral fellow

Committee career (12)：

2024 - 現在 SIGMA XI Full Membership
2023 - 現在 Japanese Pharmacological Society Association of Next Generation Scientists in Japanese Pharmacological Society
2022 - 現在 Frontiers in Molecular Neuroscience Associate Editor for Pain Mechanisms and Modulators
2022 - 現在日本薬理学会薬理学エデュケーター
2020 - 現在日本薬学会薬理系薬学部会若手世話人

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Awards (5)：

2022 - 日本薬学会中国四国支部支部奨励賞
2022 - 日本薬学会薬理系薬学部会優秀発表賞
2022 - 日本基礎老化学会若手奨励賞
2020 - National Institute on Drug Abuse IRP Featured Paper of the Month - Apil 2020
2013 - The Japanese Pharmacological Society The JPS Prize 2014 Awards

Association Membership(s) (6)：

Japan Society for Biomedical Gerontology , Society for Neuroscience , Japanese Society of Neuropsychopharmacology , Japanese Association for Study of Pain , Pharmaceutical Society of Japan , Japanese Pharmacological Society (Scientific council)

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