Takahashi Daisuke

タカハシダイスケ | Takahashi Daisuke

Affiliation and department：
Job title： Associate Professor
Homepage URL (1)： http://meneki.phar.kyushu-u.ac.jp

Research field (3)： Pharmaceuticals - health and biochemistry , Biophysics , Structural biochemistry

Research keywords (5)： Protein-Protein/lipid/carbohydrate interactions , Innate immune responses , Multidomain enzymes , Diaclyglycerol kinases , Lipid kinases

Research theme for competitive and other funds (3)：

2020 - 2023 Understanding the efficacy of therapeutic antibodies through their interaction with cellular receptors.
2019 - 2022 Structural basis for enzymatic catalysis and regulation of diacylglycerol kinase alpha
2017 - 2019 Molecular basis underlying cancer cell proliferation and T-cell anergy induction by diacylglycerol kinase alpha

Papers (43)：

Kanae Yumimoto, Shigeaki Sugiyama, Saori Motomura, Daisuke Takahashi, Keiichi I Nakayama. Molecular evolution of Keap1 was essential for adaptation of vertebrates to terrestrial life. Science advances. 2023. 9. 20. eadg2379
Keisuke Yamashita, Daisuke Takahashi, Yuki Yamamoto, Shingo Kiyomoto, Toshio Shibata, Shun-Ichiro Kawabata. Effects of Ca2+ ions on the horseshoe crab coagulation cascade triggered by lipopolysaccharide. Journal of biochemistry. 2023. 174. 1. 47-58
Yuya Hirose, Naoya Shindo, Makiko Mori, Satsuki Onitsuka, Hikaru Isogai, Rui Hamada, Tadanari Hiramoto, Jinta Ochi, Daisuke Takahashi, Tadashi Ueda, et al. Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease. Journal of medicinal chemistry. 2022. 65. 20. 13852-13865
Daisuke Takahashi, Kento Yonezawa, Yuki Okizaki, Jose M. M. Caaveiro, Tadashi Ueda, Atsushi Shimada, Fumio Sakane, Nobutaka Shimizu. Ca ²⁺ -induced structural changes and intramolecular interactions in N-terminal region of diacylglycerol kinase alpha. Protein Science. 2022. 31. 7
Daisuke Takahashi, Eri Matsunaga, Tomohiro Yamashita, Jose M M Caaveiro, Yoshito Abe, Tadashi Ueda. Compound screening identified gossypetin and isoquercitrin as novel inhibitors for amyloid fibril formations of Vλ6 proteins associated with AL amyloidosis. Biochemical and biophysical research communications. 2022. 596. 22-28

ｍore...

MISC (4)：

Daisuke Takahashi, Huaien Dai, Yasuaki Hiromasa, Ramaswamy Krishnamoorthi, Michael Kanost. Protein self-association of N-terminal domain of beta-1,3-glucan recognition protein upon binding to beta-1,3-glucan stimulates the prophenoloxidase activation in Manduca sexta. FASEB JOURNAL. 2014. 28. 1
Daisuke Takahashi, Yunjeong Kim, Kyeong-Ok Chang, Asokan Anbanandam, Om Prakash. Structural and Dynamic Characterization of Norovirus Protease. BIOPHYSICAL JOURNAL. 2012. 102. 3. 52A-53A
Daisuke Takahashi, Sanjeev K. Shukla, Om Prakash, Guolong Zhang. Structural determinants of host defense peptides for antimicrobial activity and target cell selectivity (vol 92, pg 1236, 2010). BIOCHIMIE. 2011. 93. 3. 631-631
Daisuke Takahashi, Yunjeong Kim, Kyeong-Ok Chang, Asokan Anbanandam, Om Prakash. Solution Structure Determination of Norwalk Virus 3C-Like Cysteine Protease. BIOPHYSICAL JOURNAL. 2011. 100. 3. 605-606

Education (3)：

2005 - 2008 Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences
2003 - 2005 Kyushu University Graduate School of Bioresource and Bioenvironmental Sciences
1999 - 2003 Kyushu University Department of Agriculture

Professional career (1)：

博士(農学) (九州大学)

Work history (6)：

2023/01 - Sojo University Faculty of Pharmaceutical Sciences, Department of Pharmaceutical Sciences Associate Professor
2022/01 - 2022/12 Kyushu University Department of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Science Lecturer
2018/08 - 2021/12 Kyushu University Department of Protein Structure, Function, and Design, Graduate School of Pharmaceutical Science Assistant Professor
2016/07 - 2018/07 Chiba University Graduate School of Science, Department of Chemistry, Research Assistant Professor
2011/06 - 2016/06 Kansas State University Department of Biochemistry and Molecular Biophysics Research Associate

Show all

※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

Return to Previous Page