ODA KOSUKE

オダコウスケ | ODA KOSUKE

Affiliation and department：
Job title： lecturer

Research field (2)： Structural biochemistry , Virology

Research keywords (5)：数理モデル , Accessory protein , X-ray crystallographic analysis , Paramyxovirus , Drug discovery

Research theme for competitive and other funds (17)：

2023 - 2026 Development of dual-action antimicrobial agents effective against antimicrobial resistant bacteria
2020 - 2023 Structural basis of innate immune evasion by Paramyxovirus C protein involving the binding to the novel counterpart
2018 - 2021 RNAウイルスにおける新規標的因子IFN受容体を介した自然免疫回避機構
2016 - 2019 Elucidation of interactions between paramyxoviral infection and host innate immunity
2019 - 2019 重症熱性血小板減少症候群ウイルスの病原因子NSsとマダニ因子間の相互作用の解析

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Papers (34)：

Erika Inoue, Shiyo Minatozaki, Sachi Shimizu, Sayaka Miyamoto, Misato Jo, Junjun Ni, Hidetoshi Tozaki-Saitoh, Kosuke Oda, Saori Nonaka, Hiroshi Nakanishi. Human β-Defensin 3 Inhibition of P. gingivalis LPS-Induced IL-1β Production by BV-2 Microglia through Suppression of Cathepsins B and L. Cells. 2024. 13. 3. 283-283
Basirat Mojisola Lawal-Ayinde, Tomoko Morita, Kosuke Oda, Tanuza Nazmul, Miuko Kurose, Toshihito Nomura, Akima Yamamoto, Akifumi Higashiura, Tomoyuki Akita, Junko Tanaka, et al. Virus purification highlights the high susceptibility of SARS-CoV-2 to a chlorine-based disinfectant, chlorous acid. PLOS ONE. 2023. 18. 7. e0288634-e0288634
Masaya Fukushi, Ryosuke Ohsawa, Yasushi Okinaka, Daisuke Oikawa, Tohru Kiyono, Masaya Moriwaki, Takashi Irie, Kosuke Oda, Yasuhiro Kamei, Fuminori Tokunaga, et al. Optineurin deficiency impairs autophagy to cause interferon beta overproduction and increased survival of mice following viral infection. PLOS ONE. 2023. 18. 6. e0287545-e0287545
Oda K, Sakaguchi T, Matoba. Catalytic Mechanism of DcsB: Arginase Framework Used for Hydrolyzing Its Inhibitor. Protein Science. 2022. 31. 6. e4338
Oda, Kosuke, Sakaguchi, Takemasa, Matoba, Yasuyuki. Crystal structure of O-ureidoserine racemase found in the D-cycloserine biosynthetic pathway. Proteins. 2022. 90. 4. 912-918

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MISC (1)：

野村俊仁, 坂口剛正, 大段秀樹, 森本博司, 井手健太郎, 小田康祐. サイトメガロウイルスの薬剤耐性遺伝子変異の特定を行った腎移植患者の1例. 日本化学療法学会雑誌. 2020. 68. Suppl.A. 354-354

Books (1)：

Structural Studies of Enzymes Utilized for the Stereoselective Biosynthesis of D-Cycloserine
Studies in Natural Products Chemistry, Elsevier Science Publishers

Lectures and oral presentations (52)：

Catalytic Mechanism of DcsB: Arginase Framework Used for Hydrolyzing Its Inhibitor
(IUMS2022 2022)
Similar but different catalytic mechanism of Nomega-hydroxy-L-arginine hydrolase: arginase framework used for hydrolyzing its inhibitor
(The 36th Annual Symposium of The Protein Society 2022)
アルギナーゼ阻害剤を加水分解するためアルギナーゼのフレームワークを用いたDcsBの触媒機構
(第22回日本蛋白質科学会年会 2022)
Significance of the association of the C protein with Alix for the budding of Sendai virus on the basis of the crystal structure
(IUMS2020, XVIII International Congress of Virology 2020)
サイトメガロウイルスの薬剤耐性遺伝子変異の特定を行った腎移植患者の1例
(日本化学療法学会雑誌 2020)

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Education (3)：

2007 - 2010 Hiroshima University Graduate School of Biomedical Sciences Graduate School of Biomedical Sciences
2005 - 2007 Hiroshima university
2001 - 2005 Kyoto Pharmaceutical University Faculty of Pharmaceutical Science Faculty of Pharmaceutical Science

Professional career (2)：

博士(医薬学) (広島大学)
修士(薬学) (広島大学)

Work history (9)：

2023/04 - 現在 Yasuda Women's University Faculty of Pharmacy Department of Pharmacy lecturer
2019/04 - 2023/03 Hiroshima University Graduate School of Biomedical & Health Sciences Assistant Professor
2019/04 - 2023/03 Hiroshima Minicipal College of Nursing part-time lecturer
2015/01/01 - 2019/03/31 Hiroshima University Institute of Biomedical & Health Sciences Assistant Professor
2012/05/01 - 2014/12/31 Hiroshima University Institute of Biomedical & Health Sciences Assistant Professor (Special Appointment)

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Awards (3)：

2013/11/10 - 日本ウイルス学会第61回日本ウイルス学会学術集会ポスター賞自然免疫の抑制に関わるセンダイウイルスCタンパク質と宿主転写因子STAT1の構造生物学的解析
2010/03/23 - 広島大学平成21年度広島大学大学院医歯薬学総合研究科長賞
2007/11 - 日本生物工学会平成19年度日本生物工学会西日本支部学生賞ブレオマイシンN-アセチルトランスフェラーゼの基質結合様式

Association Membership(s) (5)：

division of biotechnology , The Japanese Society for Virology , The Pharmaceutical Society of Japan , Protein Scinence Society of Japan , The Society for Biotechnology, Japan

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