Nakayama Koh

ナカヤマコウ | Nakayama Koh

Affiliation and department：
Job title： Professor

Research field (4)： Pharmacology , Tumor biology , Cell biology , Medical biochemistry

Research keywords (6)： metabolism , hypoxia response , oncology , intracellular signal transduction , cancer drug development , drug resistance

Research theme for competitive and other funds (13)：

2021 - 2024 Regulation of tumor growth mediated by pyruvate dehydrogenase PDH
2021 - 2024 慢性低酸素環境に注目した乳がんの抗アンドロゲン薬抵抗性獲得機序の解明
2018 - 2022 Comprehensive analysis of 3D nuclear gene position involved in malignant transformation of hypoxic cancer
2017 - 2019 水酸化酵素Phdの新規基質の同定を基盤とした低酸素応答システムの解明
2015 - 2018 Selective gene expression machinary during prolonged phase of hypoxia

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Papers (23)：

Koh Nakayama, Sigal Shachar, Elizabeth H Finn, Hiroyuki Sato, Akihiro Hirakawa, Tom Misteli. Large-scale mapping of positional changes of hypoxia-responsive genes upon activation. Molecular Biology of the Cell. 2022. 33. 8. ar72
Ai Amioka, Takayuki Kadoya, Satoshi Sueoka, Yoshie Kobayashi, Shinsuke Sasada, Akiko Emi, Norio Masumoto, Masaoki Ito, Koh Nakayama, Morihito Okada. Effect of Wnt5a on drug resistance in estrogen receptor-positive breast cancer. Breast cancer (Tokyo, Japan). 2021. 28. 5. 1062-1071
Eguchi K, Nakayama K. Prolonged hypoxia decreases nuclear pyruvate dehydrogenase complex and regulates the gene expression. Biochemical and biophysical research communications. 2019. 520. 1. 128-135
Ryo Yonashiro, Kayoko Eguchi, Masaki Wake, Norihiko Takeda, Koh Nakayama. Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells. Cancer research. 2018. 78. 7. 1592-1603
Gudla PR, Nakayama K, Pegoraro G, Misteli T. SpotLearn: Convolutional Neural Network for Detection of Fluorescence In Situ Hybridization (FISH) Signals in High-Throughput Imaging Approaches. Cold Spring Harbor symposia on quantitative biology. 2017. 82. 57-70

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MISC (9)：

Koh Nakayama, Naoyuki Kataoka. Regulation of Gene Expression under Hypoxic Conditions. International Journal of Molecular Sciences. 2019. 20. 13
Koh Nakayama. CREB regulates the expression of PERK and IRE1a, and controls unfolded protein response under hypoxic conditions. FASEB JOURNAL. 2016. 30
Eriko Katsuta, Shinji Tanaka, Kaoru Mogushi, Shu Shimada, Yoshimitsu Akiyama, Arihiro Aihara, Satoshi Matsumura, Yusuke Mitsunori, Daisuke Ban, Takanori Ochiai, et al. CD73: A therapeutic target for pancreatic neuroendocrine tumor stem cells. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2016. 38. S5-S5
Shinji Tanaka, Shunsuke Muramatsu, Arihiro Aihara, Rama Adikrisna, Kaoru Mogushi, Satoshi Matsumura, Daisuke Ban, Takanori Ochiai, Takumi Irie, Atsushi Kudo, et al. Visualization of stem cell features in human hepatocellular carcinoma; tumor-host interaction and clinical imapct. HEPATOLOGY. 2013. 58. 1083A-1083A
Koh Nakayama. Growth and progression of melanoma and non-melanoma skin cancers regulated by ubiquitination. Pigment Cell & Melanoma Research. 2010. 23. 3. 338-351

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Books (4)：

Lectures and oral presentations (22)：

Induction of Nuclear Gene Repositioning in response to Hypoxia -a Large Scale Analysis of Hypoxia-Responsive Genes-
(CellBio2023 2023)
早期と長期の低酸素応答を制御する分子機構
(第96回日本生化学会大会 2023)
がんの早期と長期の低酸素応答における遺伝子発現制御機構の解析
(第74回日本薬理学会北部会 2023)
Gene regulation during early and late phase of hypoxic response in cancer cells
(2022)
Regulatory mechanism of gene expression during early and late phase of hypoxic response
(2022)

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Professional career (1)：

Work history (3)：

2020/09 - 現在 Asahikawa Medical University Department of Pharmacology, School of Medicine Professor
2011/04 - 2020/08 Tokyo Medical and Dental University Medical Research Institute Advanced Molecular Medicine Oxygen Biology Associate Professor
2007/01/01 - 2011/03/31 Tokyo Medical and Dental University Medical Research Institute Medical Top Track Program Project Junior Associate Professor

Association Membership(s) (4)：

The American Society for Cell Biology , 日本生化学会 , 日本分子生物学会 , 日本薬理学会

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