Rchr
J-GLOBAL ID:201801007099895074   Update date: Nov. 05, 2024

Mitsuhashi Yuka

ミツハシ ユウカ | Mitsuhashi Yuka
Affiliation and department:
Job title: Assistant Professor
Research field  (1): Neuroscience - general
Research theme for competitive and other funds  (6):
  • 2024 - 2028 加齢依存性脱メチル化によるDNA損傷を介した神経変性解読
  • 2024 - 2027 ヒトの隠れエクソンから解き明かすシナプス刈り込みと神経変性
  • 2024 - 2027 ヘパラン硫酸プロテオグリカンを標的とした、遺伝性脳小血管病の包括的治療方法の開発
  • 2024 - 2027 DNAメチル化の摂動とDNA損傷・修復応答に着目した孤発性ALSの病態解明
  • 2023 - 2026 TDP-43陰性単一核のメチローム,トランスクリプトーム解析による,孤発性ALS/FTD早期病態の解明
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Papers (43):
  • Yuka Koike, Osamu Onodera. Lessons from the ATTeST trial in ataxia telangiectasia. The Lancet. Neurology. 2024. 23. 9. 846-847
  • Takuma Yamagishi, Shingo Koide, Genri Toyama, Aya Washida, Yumi Yamada, Ryutaro Hanyu, Ekaterina Nadbitova, Yuka Mitsuhashi Koike, Takuya Konno, Tomohiko Ishihara, et al. ASO-enhancement ofTARDBPexitron splicing mitigates TDP-43 proteinopathies. 2024
  • Yuka Koike. Abnormal Splicing Events due to Loss of Nuclear Function of TDP-43: Pathophysiology and Perspectives. JMA journal. 2024. 7. 3. 313-318
  • Yuka Koike. Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes. Neuroscience research. 2024
  • Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, et al. Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine. 2024
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MISC (14):
  • 坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
  • 小池佑佳, 須貝章弘, 原範和, 伊藤絢子, 横関明男, 石原智彦, 山岸拓磨, 坪口晋太朗, 他田真理, 池内健, et al. 加齢と関連したDNA脱メチル化がTDP-43量の自己調節機構を障害する. Dementia Japan. 2021. 35. 4
  • 小池 佑佳, 加藤 泰介, 廣川 祥子, 小林 憲太, 辻 省次, 小野寺 理. 歯状核赤核・淡蒼球ルイ体萎縮症モデルマウスに対するゲノム編集効果. 神経治療学. 2019. 36. 6. S218-S218
  • Koike Yuka, 加藤 泰介, 廣川 祥子, 小林 憲太, 辻 省次, 小野寺 理. Therapeutic strategy based on genome editing for dentatorubral-pallidoluysian atrophy(和訳中). てんかん研究. 2019. 37. 2. 549-549
  • 小池 佑佳, 須貝 章弘, 小野寺 理. Disturbance of balance between brain protein and its target RNA. 細胞. 2018. 50. 6. 303-306
more...
Education (2):
  • 2015 - 2019 Niigata University
  • 2004 - 2010 Niigata University Faculty of Medicine School of Medicine
Professional career (1):
  • Ph.D. (Niigata University)
Work history (5):
  • 2023/04 - 現在 Niigata University Brain Research Institute Center for Bioresources Brain Science Branch Department of Molecular Neuroscience Assistant Professor
  • 2021/07 - 2023/03 Mayo Clinic Florida Department of Neuroscience Senior Research Fellow
  • 2020/07 - 2021/06 Mayo Clinic Florida Department of Neuroscience Research Fellow
  • 2020/04 - 2020/06 Niigata University Brain Research Institute Clinical Neuroscience Branch Department of Neurology Research Fellow
  • 2019/04 - 2020/03 Niigata University Brain Research Institute Clinical Neuroscience Branch Department of Neurology Specially Appointed Assistant Professor
Awards (6):
  • 2024/07 - 2024年度日本神経科学学会奨励賞
  • 2024/03 - 令和5年度新潟県医師会学術研究 学術奨励賞
  • 2023/11 - 令和5年度日本医師会医学研究奨励賞(基礎部門)
  • 2022/12 - せりか基金 第6回せりか賞
  • 2021/11 - 日本認知症学会 第40回日本認知症学会学術奨励賞 基礎研究部門
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