Rchr
J-GLOBAL ID:201801007099895074   Update date: Jun. 21, 2024

Mitsuhashi Yuka

ミツハシ ユウカ | Mitsuhashi Yuka
Affiliation and department:
Research field  (1): Neuroscience - general
Research theme for competitive and other funds  (2):
  • 2024 - 2027 DNAメチル化の摂動とDNA損傷・修復応答に着目した孤発性ALSの病態解明
  • 2019 - 2020 DNAメチル化がTDP-43の自己調節に与える影響に着目したALS病態の解明
Papers (39):
  • Yuka Koike. Molecular mechanisms linking loss of TDP-43 function to amyotrophic lateral sclerosis/frontotemporal dementia-related genes. Neuroscience research. 2024
  • Sahba Seddighi, Yue A Qi, Anna-Leigh Brown, Oscar G Wilkins, Colleen Bereda, Cedric Belair, Yong-Jie Zhang, Mercedes Prudencio, Matthew J Keuss, Aditya Khandeshi, et al. Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science translational medicine. 2024. eadg7162
  • Shintaro Tsuboguchi, Yuka Nakamura, Tomohiko Ishihara, Taisuke Kato, Tokiharu Sato, Akihide Koyama, Hideki Mori, Yuka Koike, Osamu Onodera, Masaki Ueno. TDP-43 differentially propagates to induce antero- and retrograde degeneration in the corticospinal circuits in mouse focal ALS models. Acta neuropathologica. 2023
  • Sarah Pickles, Desiree Zanetti Alepuz, Yuka Koike, Mei Yue, Jimei Tong, Pinghu Liu, Yugui Zhou, Karen Jansen-West, Lillian M. Daughrity, Yuping Song, et al. CRISPR interference to evaluate modifiers of C9ORF72-mediated toxicity in FTD. Frontiers in Cell and Developmental Biology. 2023. 11
  • Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A. Qi, Ziyi Li, Lillian M. Daughrity, Mei Yue, Yong-Jie Zhang, Casey N. Cook, et al. TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A. PLOS Biology. 2023. 21. 3. e3002028-e3002028
more...
MISC (14):
  • 坪口晋太朗, 中村由香, 石原智彦, 加藤泰介, 佐藤時春, 小山哲秀, 森秀樹, 小池佑佳, 小野寺理, 小野寺理, et al. TDP-43 differentially propagates to induce degeneration in the motor circuit. Dementia Japan. 2023. 37. 4
  • 小池佑佳, 須貝章弘, 原範和, 伊藤絢子, 横関明男, 石原智彦, 山岸拓磨, 坪口晋太朗, 他田真理, 池内健, et al. 加齢と関連したDNA脱メチル化がTDP-43量の自己調節機構を障害する. Dementia Japan. 2021. 35. 4
  • 小池 佑佳, 加藤 泰介, 廣川 祥子, 小林 憲太, 辻 省次, 小野寺 理. 歯状核赤核・淡蒼球ルイ体萎縮症モデルマウスに対するゲノム編集効果. 神経治療学. 2019. 36. 6. S218-S218
  • Koike Yuka, 加藤 泰介, 廣川 祥子, 小林 憲太, 辻 省次, 小野寺 理. Therapeutic strategy based on genome editing for dentatorubral-pallidoluysian atrophy(和訳中). てんかん研究. 2019. 37. 2. 549-549
  • 小池 佑佳, 須貝 章弘, 小野寺 理. Disturbance of balance between brain protein and its target RNA. 細胞. 2018. 50. 6. 303-306
more...
Education (2):
  • 2015 - 2019 Niigata University
  • 2004 - 2010 Niigata University Faculty of Medicine School of Medicine
Professional career (1):
  • Ph.D. (Niigata University)
Awards (4):
  • 2023/11 - 令和5年度日本医師会医学研究奨励賞(基礎部門)
  • 2022/12 - せりか基金 第6回せりか賞
  • 2021/11 - 日本認知症学会 第40回日本認知症学会学術奨励賞 基礎研究部門
  • 2019/11 - 日本神経治療学会 第37回日本神経治療学会優秀演題賞
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