Rchr
J-GLOBAL ID：201801007186939363
Update date: Aug. 29, 2024
Yamatsugu Kenzo
ヤマツグ ケンゾウ | Yamatsugu Kenzo
Affiliation and department：
Job title：
Professor
Research field (2)：
Biochemistry
, Pharmaceuticals - chemistry and drug development
Research keywords (5)：
Medicinal Chemistry
, Protein Chemistry
, Post-translational Modifications
, Chemical Biology
, Organic Chemistry
Research theme for competitive and other funds (6)：
- 2021 - 2024 酵素には不可能なヒストン超アシル化による生細胞エピゲノム操作と理解
- 2019 - 2023 化学触媒ツールの開発を基軸としたヒストン修飾とDNA修復の相関解明
- 2019 - 2023 タンパク質化学合成を革新するペプチド連結触媒の開発
- 2018 - 2020 分子夾雑下ヒストンアシル化による細胞機能制御を可能にする化学触媒システムの開発
- 2017 - 2020 Direct, catalytic , and site-selective phosphorylation of hydroxy group using molecular recognition and dynamic covalent bonding
- 2014 - 2018 Regulation of subcellular localization and functions of proteins by in-cell catalytic reactions
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Papers (62)：
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Yuki Yamanashi, Shinpei Takamaru, Atsushi Okabe, Satoshi Kaito, Yuto Azumaya, Yugo Kamimura, Kenzo Yamatsugu, Tomoya Kujirai, Hitoshi Kurumizaka, Atsushi Iwama, et al. Chemical catalyst manipulating cancer epigenome and transcription. 2024
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Tamiko Nozaki, Mayu Onoda, Misuzu Habazaki, Yuma Takeuchi, Hisashi Ishida, Yuko Sato, Tomoya Kujirai, Kayo Hanada, Kenzo Yamatsugu, Hitoshi Kurumizaka, et al. Logics for Developing Regioselective Histone Acetylating Catalysts. 2024
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Toshifumi Tatsumi, Songji Zhao, Akitomo Kasahara, Miho Aoki, Ken-ichi Nishijima, Naoyuki Ukon, Tatsuhiko Kodama, Kazuhiro Takahashi, Akira Sugiyama, Kohshin Washiyama, et al. In vivo-stable bis-iminobiotin for targeted radionuclide delivery with the mutant streptavidin. Bioorganic & Medicinal Chemistry Letters. 2024. 129803-129803
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Kenji Shimazoe, Kim Donghwan, Tomoko Mineo, Takeshi Sato, Seiichi Ohta, Toshifumi Tatsumi, Akira Sugiyama, Kenzo Yamatsugu, Sachiyo Nomura, Ryohei Terabayashi, et al. pH dependence of perturbed angular correlation in DOTA chelated $$^{111}$$In measured with ring-shape gamma-ray detectors. Interactions. 2024. 245. 1
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Akiko Fujimura, Hisashi Ishida, Tamiko Nozaki, Shuhei Terada, Yuto Azumaya, Tadashi Ishiguro, Yugo R Kamimura, Tomoya Kujirai, Hitoshi Kurumizaka, Hidetoshi Kono, et al. Designer Adaptor Proteins for Functional Conversion of Peptides to Small-Molecule Ligands toward In-Cell Catalytic Protein Modification. ACS central science. 2023. 9. 11. 2115-2128
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MISC (16)：
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巽俊文, 山次健三, 杉山暁, 趙松吉, 粟生木美穂, 西嶋剣一, 右近直之, 下山彩希, 譚成博, 城寶大輝, et al. 低免疫原性ストレプトアビジン変異体と改変ビオチンを用いるプレターゲティングシステムの開発. 放射化学. 2023. 47
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Kohshin Washiyama, Toshifumi Tatsumi, Akira Sugiyama, Songji Zhao, Miho Aoki, Kenzo Yamatsugu, Ken-ichi Nishijima, Naoyuki Ukon, Saki, Taiki Joho, et al. Synthesis and Astatine Labeling of a bis-iminobiotin derivative with enhanced plasma stability. NUCLEAR MEDICINE AND BIOLOGY. 2022. 108. S121-S121
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山次健三, 高橋和希, 加藤洋人, 山下雄史, 安藝翔, 巽俊文, 金子雄大, 川村猛, 三浦麻衣, 石井正純, et al. Antibody-Mimetic Drug Conjugate: AMDC comprised of modified streptavidin and bisiminobiotin, and its use in near-infrared phototherapy. メディシナルケミストリーシンポジウム講演要旨集. 2022. 39th (CD-ROM)
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巽俊文, 山次健三, 杉山暁, ZHAO S., 粟生木美穂, 西嶋剣一, 右近直之, 下山彩希, GAO F., 城寶大輝, et al. Development of pre-targeting system using low immunogenic streptavidin mutants and 211-At-labeled bis-iminobiotin. 日本放射化学会討論会(Web). 2022. 66th
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高橋和希, 山次健三, 加藤洋人, 山下雄史, 安藝翔, 巽俊文, 金子雄大, 川村猛, 川村猛, 三浦麻衣, et al. Near-infrared Phototherapy Using Modified Streptavidin-iminobiotin Drug Delivery System. 日本薬学会年会要旨集(Web). 2022. 142nd
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Education (2)：
- 2005 - 2010 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 2001 - 2005 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
- PhD (The University of Tokyo)
Work history (5)：
- 2023/04 - 現在 Chiba University Graduate School of Pharmaceutical Sciences Professor
- 2015/04 - 2023/04 The University of Tokyo Graduate School of Pharmaceutical Sciences
- 2012/10 - 2018/03 ERATO金井触媒分子生命プロジェクト グループリーダー
- 2011/04 - 2012/09 米国ウィスコンシン州立大学マディソン校 博士研究員
- 2010/04 - 2011/03 微生物化学研究所 博士研究員
Awards (6)：
Association Membership(s) (3)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, 日本化学会
