2020 - 2025 Biophysical Chemistry for Material Symbiosis
2020 - 2025 Identification of Symbiotic Communication between Artificial Nucleic Acids and Human Immune Systems
2022 - 2024 組織標的化リガンドによる核酸医薬のオンデマンド送達の実現
2019 - 2022 Establishment of a new platform for nucleic acid oral formulation technology to realize patient-friendly nucleic acid medicines
2019 - 2022 Development of drug delivery system for CRISPR/Cas9 for the treatment of familial hypercholesterolemia
2019 - 2021 Development of small molecules that target HIV-1 latency-associated long non-coding RNA for virus eradication
2017 - 2019 生産的オリゴ核酸の動態経路の解明と核酸創薬への応用
2013 - 2015 The identification of long-noncoding RNAs associated with the formation of atherosclerotic plaques and their therapeutic manipulation strategy
2012 - 2014 The Development of Highly Effective BNA-based Antisense Oligonucleotides
2011 - 2011 高機能性アンチセンス分子による家族性高コレステロール血症治療法の開発
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Papers (54)：
Chisato Terada, Kaho Oh, Ryutaro Tsubaki, Bun Chan, Nozomi Aibara, Kaname Ohyama, Masa-Aki Shibata, Takehiko Wada, Mariko Harada-Shiba, Asako Yamayoshi, et al. Dynamic and static control of the off-target interactions of antisense oligonucleotides using toehold chemistry. Nature Communications. 2023. 14. 1
Shota Oyama, Mao Tomita, Moeka Hata, Yu Mikame, Tsuyoshi Yamamoto, Eishi Ashihara, Asako Yamayoshi. Exosome-Hijacking Drug Delivery System with Branched Arginine Linker Effectively Deliver Antisense Oligonucleotides into Lung Adenocarcinoma Cells. Chemical & pharmaceutical bulletin. 2023. 71. 11. 819-823
Yu Mikame, Honoka Eshima, Haruki Toyama, Juki Nakao, Misaki Matsuo, Tsuyoshi Yamamoto, Yoshiyuki Hari, Jun A Komano, Asako Yamayoshi. Development and Crosslinking Properties of Psoralen-Conjugated Triplex-Forming Oligonucleotides as Antigene Tools Targeting Genome DNA. ChemMedChem. 2023. e202300348
Sachiko Horie, Yasuhiro Suzuki, Tsuyoshi Yamamoto, Satoshi Obika, Kohta Mohri, Chizuru Kiyota, Qin Ren, Shota Warashina, Yasuhiro Wada, Yasuyoshi Watanabe, et al. Novel strategy of liver cancer treatment with modified antisense oligonucleotides targeting human vasohibin-2. Cancer science. 2023
Juki Nakao, Yu Mikame, Honoka Eshima, Tsuyoshi Yamamoto, Chikara Dohno, Takehiko Wada, Asako Yamayoshi. Unique Crosslinking Properties of Psoralen-conjugated Oligonucleotides developed by Novel Psoralen N-Hydroxysuccinimide Esters. Chembiochem : a European journal of chemical biology. 2023. e202200789
Toehold Nanoarchitecture That Mitigates ASO off-Target Interactions
(Cambridge Healthtech Institute’s 9th Annual Oligonucleotide Discovery & Delivery Optimizing Design and Performance and Reviewing Advances in the Clinic (OPT congress) 2024)
Application of DNA nanotechnology for Antisense Therapeutics
(The 29th Annual Meeting of Japan Society of Gene and Cell Therapy (JSGCT2023) 2023)
BROTHERS Technology for Clinical Application of Antisense Oligonucleotides
(The 8th Annual Meeting of the Nucleic Acids Therapeutics Society of Japan 2023)
2023/05 - 現在 Liid Pharmaceuticals, Inc. Executive Director
2018/09 - 現在 Nagasaki University Graduate School of Biomedical Sciences Associate Professor
2015/06 - 2018/08 National Cancer Institute Laboratory of Chemical Biology Visiting Fellow/Special Volunteer
2012/04 - 2017/02 Osaka University Graduate School of Pharmaceutical Sciences Assistant Professor
Committee career (1)：
2022/04 - 現在 日本薬学会 2022年度ダイバーシティ推進委員会委員
Awards (3)：
2022/08 - Nucleic Acids Therapeutics Society of Japan The Nucleic Acids Therapeutics Society of Japan (NatsJ) Award for Young Scientists Development of drug discovery and development scheme for therapeutic antisense oligonucleotides
2014 - アンチセンス・遺伝子・デリバリーシンポジウム 奨励賞
2014 - 上原記念科学生命財団 海外留学助成リサーチフェローシップ
Association Membership(s) (3)：
American Chemical Society
, 遺伝子・デリバリー研究会
, THE CHEMICAL SOCIETY OF JAPAN
