Ohnuma Kei

Affiliation and department：
Homepage URL (1)： https://www.juntendo.ac.jp/graduate/laboratory/labo/immunity_cancer/

Research field (6)： Fetal medicine/Pediatrics , Hematology and oncology , Allergies and connective tissue disease , Immunology , Tumor biology , Molecular biology

Research theme for competitive and other funds (13)：

2020 - 2023 ヒト免疫特有の炎症性因子IL-26に基づく慢性炎症病態の解明と新規治療法の開発
2018 - 2021 Scientific research on development of anti-fibrotic agent targeting multi-organ profibrotic factor IL-26 in GVHD
2016 - 2020 Prevention of chronic GVHD onset by HMGB1 inhibiton of DPP4
2016 - 2019 Molecular understanding of CD26-mediated immune regulatory mechanism and development of novel molecular targeted therapy for the treatment of refractory autoimmune diseases
2015 - 2018 Mechanism of lung fibrosis in chronic GVHD

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Papers (120)：

Shun Sato, Takeshi Kawasaki, Ryo Hatano, Yu Koyanagi, Yukiko Takahashi, Kei Ohnuma, Chikao Morimoto, Steven M Dudek, Koichiro Tatsumi, Takuji Suzuki. Functional roles of CD26/DPP4 in lipopolysaccharide-induced lung injury. American journal of physiology. Lung cellular and molecular physiology. 2024
Ryo Hatano, Takumi Itoh, Haruna Otsuka, Harumi Saeki, Ayako Yamamoto, Dan Song, Yuki Shirakawa, Satoshi Iyama, Tsutomu Sato, Noriaki Iwao, et al. Humanized anti-IL -26 monoclonal antibody as a novel targeted therapy for chronic graft-versus-host disease. American Journal of Transplantation. 2022
Eriko Komiya, Mitsutoshi Tominaga, Ryo Hatano, Yuji Kamikubo, Sumika Toyama, Hakushun Sakairi, Kotaro Honda, Takumi Itoh, Yayoi Kamata, Munehiro Tsurumachi, et al. Peripheral endomorphins drive mechanical alloknesis under the enzymatic control of CD26/DPPIV. Journal of Allergy and Clinical Immunology. 2021. 149. 3. 1085-1096
Takumi Itoh, Ryo Hatano, Yoshiya Horimoto, Taketo Yamada, Dan Song, Haruna Otsuka, Yuki Shirakawa, Shuji Mastuoka, Noriaki Iwao, Thomas M. Aune, et al. IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells. Cell Death & Disease. 2021. 12. 6. 520-520
Yutaro Kaneko, Ryo Hatano, Naoto Hirota, Nicolas Isambert, Véronique Trillet-Lenoir, Benoit You, Jérôme Alexandre, Gérard Zalcman, Fanny Valleix, Thomas Podoll, et al. Serum soluble CD26/DPP4 titer variation is a potential prognostic biomarker in cancer therapy with a humanized anti-CD26 antibody. Biomarker Research. 2021. 9. 1. 21-21

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MISC (51)：

古宮栄利子, 冨永光俊, 冨永光俊, 波多野良, 外山扇雅, 伊藤匠, 鎌田弥生, 鎌田弥生, 本田耕太郎, 大沼圭, et al. CD26/dipeptidyl-peptidase IVは機械的かゆみの調節因子である. 日本病態プロテアーゼ学会学術集会プログラム抄録集. 2021. 26th
古宮栄利子, 冨永光俊, 波多野良, 伊藤匠, 大塚春奈, 本田耕太郎, 外山扇雅, 鎌田弥生, 大沼圭, 森本幾夫, et al. 加齢皮膚で誘発される機械的かゆみ調節機構の解明. 加齢皮膚医学セミナー. 2020. 15. 1. 42-42
Chronic inflammation affects GVHD. BIO Clinica. 2019. 8(1). 22. 128-133
古宮栄利子, 松田浩則, 冨永光俊, 高森建二, 波多野良, 大塚春奈, 伊藤匠, 大沼圭, 森本幾夫, 須賀康. 機械的かゆみの調節メカニズムの解明. 日本皮膚科学会雑誌. 2019. 129. 4. 596-596
古宮栄利子, 波多野良, 冨永光俊, 伊藤匠, 鎌田弥生, 本田耕太郎, 外山扇雅, カタリナサギタモニアガ, 大沼圭, 森本幾夫, et al. CD26/dipeptidyl-peptidase IVは機械的かゆみの抑制因子である. 日本病態プロテアーゼ学会学術集会プログラム抄録集. 2019. 24th

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Patents (11)：

抗CD26抗体と免疫チェックポイント阻害剤との併用療法
抗癌剤への抵抗改善剤
抗癌剤への抵抗性改善剤
免疫チェックポイント阻害剤
森本幾夫大沼圭波多野良伊藤匠

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Books (10)：

Advanced in Medicine and Biology
Nova Science Publishers Inc 2019
Advances in Medicine and Biology
Nova Science Publishers Inc 2018
Horizons in Cancer Research
Nova Science Publishers Inc 2017
小児処方ノート
中外医学社 2001 ISBN:4498045831
小児処方ノート
中外医学社 2001 ISBN:4498045831

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Lectures and oral presentations (46)：

Possible regulation of mechanical itch by CD26/DPPIV
(10th World Congress on Itch (WCI) 2019)
Possible role for CD26/DPPIV in regulating mechanical itch (Alloknesis)
(28th European Academy of Dermatology and Venereology (EADV) Congress 2019)
CD26/DPPIV regulates mechanical itch by enzymatic degradation of mu-opioid receptor ligands
(24th World Congress of Dermatology (WCD) 2019)
Interleukin-26-targeted therapy for the control of chronic GVHD
(2018)
乾癬における新規炎症性サイトカインIL-26の役割と分子標的療法の開発
(第33回日本乾癬学会学術大会 2018)

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Professional career (1)：

博士(医学) (東京大学大学院)

Committee career (2)：

日本リウマチ学会評議員
日本血液学会評議員

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